• The University of Western Australia (M517), 35 Stirling Highway,

    6009 Perth

    Australia

  • 386 Citations
  • 9 h-Index
20042019
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Research Output 2004 2019

2004
42 Citations (Scopus)

Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells

Mellough, C. B., Cui, Q., Spalding, K. L., Symons, N. A., Pollett, M., Snyder, E. Y., Macklis, J. D. & Harvey, A., 2004, In : Experimental Neurology. 186, 1, p. 6-19

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Retina
Superior Colliculi
Optic Nerve Injuries
Cell Death
2005
218 Downloads (Pure)
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Retinal Ganglion Cells
Rodentia
Transplantation
Retina
Superior Colliculi
2006
94 Citations (Scopus)

Gene therapy and transplantation in CNS repair: The visual system

Harvey, A., Hu, Y., Leaver, S., Mellough, C., Park, K., Verhaagen, J., Plant, G. & Cui, Q., 2006, In : Progress in Retinal and Eye Research. 25, 5, p. 449-489

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Genetic Therapy
Central Nervous System
Transplantation
Axons
2009
8 Citations (Scopus)

Genetic basis of inherited macular dystrophies and implications for stem cell therapy

Mellough, C. B., Steel, D. H. W. & Lako, M., Nov 2009, In : Stem Cells. 27, 11, p. 2833-45 13 p.

Research output: Contribution to journalReview article

Macular Degeneration
Cell- and Tissue-Based Therapy
Stem Cells
Genetic Testing
Ethics
2011
2 Citations (Scopus)

Neurite formation by neurons derived from adult rat hippocampal progenitor cells is susceptible to myelin inhibition

Mellough, C. B., Cho, S., Wood, A. & Przyborski, S., Sep 2011, In : Neurochemistry International. 59, 3, p. 333-340 8 p.

Research output: Contribution to journalArticle

Neurites
Myelin Sheath
Myelin-Associated Glycoprotein
Stem Cells
Neurons
2012
96 Citations (Scopus)

Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells

Mellough, C. B., Sernagor, E., Moreno-Gimeno, I., Steel, D. H. W. & Lako, M., Apr 2012, In : Stem Cells. 30, 4, p. 673-686 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Vertebrate Photoreceptor Cells
Photoreceptor Cells
Aptitude
2014
9 Citations (Scopus)

Lab generated retina: Realizing the dream

Mellough, C. B., Collin, J., Sernagor, E., Wride, N. K., Steel, D. H. W. & Lako, M., Sep 2014, In : Visual Neuroscience. 31, 4-5, p. 317-332 16 p.

Research output: Contribution to journalReview article

Pluripotent Stem Cells
Blindness
Retina
Aptitude
Drug Discovery
2015
42 Citations (Scopus)

IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells

Mellough, C. B., Collin, J., Khazim, M., White, K., Sernagor, E., Steel, D. H. W. & Lako, M., Aug 2015, In : Stem Cells. 33, 8, p. 2416-2430 15 p.

Research output: Contribution to journalArticle

Open Access
Somatomedins
Retina
Light Signal Transduction
Retinal Cone Photoreceptor Cells
Somatomedin Receptors

Use of induced pluripotent stem-cell technology to understand photoreceptor cytoskeletal dynamics in retinitis pigmentosa

Megaw, R., Mellough, C., Wright, A., Lako, M. & Ffrench-Constant, C., 26 Feb 2015, In : Lancet. 385 , Supp. 1, p. S69

Research output: Contribution to journalAbstract/Meeting Abstract

Induced Pluripotent Stem Cells
Retinitis Pigmentosa
GTP Phosphohydrolases
Technology
Actins
2016

How to build a human

Mellough, C. B. & Lako, M., 24 Aug 2016, In : eLife. 5, e19826.

Research output: Contribution to journalEditorial

Open Access
Embryonic Structures
Genes
Tissue
11 Citations (Scopus)

Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation

Collin, J., Mellough, C. B., Dorgau, B., Przyborski, S., Moreno-Gimeno, I. & Lako, M., Feb 2016, In : Stem Cells. 34, 2, p. 311-321 11 p.

Research output: Contribution to journalArticle

Open Access
Pluripotent Stem Cells
Vertebrate Photoreceptor Cells
Homeobox Genes
Zinc Fingers
Green Fluorescent Proteins
2017
37 Citations (Scopus)

3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development

Hunt, N. C., Hallam, D., Karimi, A., Mellough, C. B., Chen, J., Steel, D. H. W. & Lako, M., Feb 2017, In : Acta Biomaterialia. 49, p. 329-343 15 p.

Research output: Contribution to journalArticle

Open Access
Pluripotent Stem Cells
Hydrogel
Alginate
Stem cells
Cell culture
11 Citations (Scopus)

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure

Hallam, D., Collin, J., Bojic, S., Chichagova, V., Buskin, A., Xu, Y., Lafage, L., Otten, E. G., Anyfantis, G., Mellough, C., Przyborski, S., Alharthi, S., Korolchuk, V., Lotery, A., Saretzki, G., McKibbin, M., Armstrong, L., Steel, D., Kavanagh, D. & Lako, M., 1 Nov 2017, In : Stem Cells. 35, 11, p. 2305-2320 16 p.

Research output: Contribution to journalArticle

Open Access
Complement Factor H
Induced Pluripotent Stem Cells
Macular Degeneration
Ultraviolet Rays
Retinal Pigment Epithelium
14 Citations (Scopus)

Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models

Megaw, R., Abu-Arafeh, H., Jungnickel, M., Mellough, C., Gurniak, C., Witke, W., Zhang, W., Khanna, H., Mill, P., Dhillon, B., Wright, A. F., Lako, M. & Ffrench-Constant, C., 16 Aug 2017, In : Nature Communications. 8, 1, 271.

Research output: Contribution to journalArticle

Open Access
Gelsolin
photoreceptors
Retinitis Pigmentosa
GTP Phosphohydrolases
regulators

THE GENERATION OF USEFUL HUMAN RETINAL TISSUE FROM HUMAN PLURIPOTENT STEM CELLS FOR THE STUDY OF OPHTHALMIC DEVELOPMENT, HEALTH AND DISEASE

Mellough, C. B., Collin, J., Sernagor, E., Chen, F. K., Degli-Esposti, M. & Lako, M., Oct 2017, In : Clinical & Experimental Ophthalmology. 45, p. 141-141 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2018

3D retina organoids produced from CRX-GFP human embryonic stem cells (hESCs) processed into retinal sheets and transplanted into immunodeficient retinal degenerate (RD) rats

Seiler, M. J., McLelland, B. T., Collin, J., Mellough, C. B., Lako, M., Aramant, R. B., Nistor, G. & Keirstead, H. S., Jul 2018, In : Investigative ophthalmology & visual science. 59, 9, 3 p., 544.

Research output: Contribution to journalAbstract/Meeting Abstract

8 Citations (Scopus)

Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular

Izuogu, O. G., Alhasan, A. A., Mellough, C., Collin, J., Gallon, R., Hyslop, J., Mastrorosa, F. K., Ehrmann, I., Lako, M., Elliott, D. J., Santibanez-Koref, M. & Jackson, M. S., 20 Apr 2018, In : BMC Genomics. 19, 18 p., 276.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix

Felemban, M., Dorgau, B., Hunt, N. C., Hallam, D., Zerti, D., Bauer, R., Ding, Y., Collin, J., Steel, D., Krasnogor, N., Al-Aama, J., Lindsay, S., Mellough, C. & Lako, M., 1 Jul 2018, In : Acta Biomaterialia. 74, p. 207-221 15 p.

Research output: Contribution to journalArticle

Open Access
Organoids
Pluripotent Stem Cells
Proteoglycans
Stem cells
Extracellular Matrix

INDUCED PLURIPOTENT STEM CELL MODELS OF RETINITIS PIGMENTOSA CAUSED BY RP1 MUTATION

Moon, S. Y., Zhang, X., Zhang, D., Chen, S-C., De Roach, J., Lamey, T., Mellough, C., Hodgetts, S., Chen, F. & McLenachan, S., Nov 2018, In : Clinical and Experimental Ophthalmology. 46, p. 127-127 1 p., 109.

Research output: Contribution to journalAbstract/Meeting Abstract

Laminin gamma 3 expression and its functional role during human retinal morphogenesis

Dorgau, B., Sharpe, A., Felemban, M., Hallam, D., Steel, D., Lindsay, S., Mellough, C. B. & Lako, M., Jul 2018, In : Investigative ophthalmology & visual science. 59, 9, 3 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2 Citations (Scopus)

Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation

Dorgau, B., Felemban, M., Sharpe, A., Bauer, R., Hallam, D., Steel, D. H., Lindsay, S., Mellough, C. & Lako, M., 1 Jun 2018, In : Cell Death and Disease. 9, 6, 648.

Research output: Contribution to journalArticle

Open Access
Vertebrate Photoreceptor Cells
Laminin
Ganglia
Cell Differentiation
Organizations
2019
4 Citations (Scopus)

An integrated transcriptional analysis of the developing human retina

Mellough, C. B., Bauer, R., Collin, J., Dorgau, B., Zerti, D., Dolan, D. W. P., Jones, C. M., Izuogu, O. G., Yu, M., Hallam, D., Steyn, J. S., Whites, K., Steel, D. H., Santibanez-Koref, M., Elliott, D. J., Jackson, M. S., Lindsay, S., Grellscheid, S. & Lako, M., 15 Jan 2019, In : Development. 146, 2, 16 p., 169474.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

Mellough, C. B., Collin, J., Queen, R., Hilgen, G., Dorgau, B., Zerti, D., Felemban, M., White, K., Sernagor, E. & Lako, M., Jul 2019, In : Stem Cells Translational Medicine. 8, 7, p. 694-706

Research output: Contribution to journalArticle

Open Access
Organoids
Embryoid Bodies
Pluripotent Stem Cells
Cell Line
Maintenance