Research Output per year
Research Output per year
Personal profile
Biography
My research investigates the molecular aspects of G protein-coupled receptor pharmacology. Specifically, the ability of cell-type-specific factors to modulate signaling of chemokine receptors, an important class of membrane proteins found thought the body. By using CRISPR/Cas9 genome-editing I have developed cutting-edge bioluminescence techniques to investigate endogenous protein-protein and ligand-receptor interactions as well as receptor signaling.
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Research Output
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CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes
White, C. W., Caspar, B., Vanyai, H. K., Pfleger, K. D. G. & Hill, S. J., 7 Feb 2020, In : Cell Chemical Biology. p. 1-12 20 p.Research output: Contribution to journal › Article
Open Access7 Citations (Scopus) -
Complex Formation between VEGFR2 and the β2-Adrenoceptor
Kilpatrick, L. E., Alcobia, D. C., White, C. W., Peach, C. J., Glenn, J. R., Zimmerman, K., Kondrashov, A., Pfleger, K. D. G., Ohana, R. F., Robers, M. B., Wood, K. V., Sloan, E. K., Woolard, J. & Hill, S. J., 20 Jun 2019, In : Cell Chemical Biology. 26, 6, p. 830-841.e9 21 p.Research output: Contribution to journal › Article
Open Access5 Citations (Scopus) -
NanoBRET: The Bright Future of Proximity-Based Assays
Dale, N. C., Johnstone, E. K. M., White, C. W. & Pfleger, K. D. G., 26 Mar 2019, In : Frontiers in Bioengineering and Biotechnology. 7, MAR, 13 p., 56.Research output: Contribution to journal › Review article
Open Access17 Citations (Scopus) -
NanoBRET ligand binding at a GPCR under endogenous promotion facilitated by CRISPR/Cas9 genome editing
White, C. W., Johnstone, E. K. M., See, H. B. & Pfleger, K. D. G., Feb 2019, In : Cellular Signalling. 54, p. 27-34 8 p.Research output: Contribution to journal › Article
Open AccessFile14 Citations (Scopus)586 Downloads (Pure) -
Optimised insert design for improved single-molecule imaging and quantification through CRISPR-Cas9 mediated knock-in
Khan, A. O., White, C. W., Pike, J. A., Yule, J., Slater, A., Hill, S. J., Poulter, N. S., Thomas, S. G. & Morgan, N. V., 2 Oct 2019, In : Scientific Reports. 9, 1, 1 p.Research output: Contribution to journal › Article
Open Access9 Citations (Scopus)
Datasets
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Data from: CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes
White, C. (Creator), Caspar, B. (Creator), Vanyai, H. (Creator), Pfleger, K. (Creator) & Hill, S. (Creator), Elsevier, 12 Feb 2020
DOI: 10.1016/j.chembiol.2020.01.010, https://ars.els-cdn.com/content/image/1-s2.0-S2451945620300350-mmc1.pdf
Dataset
Projects
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Molecular pharmacology of chemokine receptor signalling in cancer
National Health & Medical Research Council NHMRC
1/01/15 → 31/12/21
Project: Research
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Receptor tyrosine kinase pharmacology and cutting edge fluorescence technologies
Pfleger, K., Kilpatrick, L., White, C. & Hill, S.
The University of Western Australia
1/01/16 → 31/12/16
Project: Research