Brad Zhang

Dr, PhD Curtin

  • The University of Western Australia (M561), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1053 Citations
  • 17 h-Index
20062019
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Research Output 2006 2019

  • 1053 Citations
  • 17 h-Index
  • 52 Article
  • 4 Letter
  • 3 Review article
  • 1 Abstract/Meeting Abstract
2019
Tonsillectomy
Premedication
Albuterol
Anesthetics
Randomized Controlled Trials

Upper airway cell transcriptomics identify a major new immunological phenotype with strong clinical correlates in young children with acute wheezing

Khoo, S. K., Read, J., Franks, K., Zhang, G., Bizzintino, J., Coleman, L., McCrae, C., Öberg, L., Troy, N. M., Prastanti, F., Everard, J., Oo, S., Borland, M. L., Maciewicz, R. A., Le Souëf, P. N., Laing, I. A. & Bosco, A., 1 Jan 2019, In : Journal of Immunology. 202, 6, p. 1845-1858 14 p.

Research output: Contribution to journalArticle

Respiratory Sounds
Phenotype
Asthma
Up-Regulation
Rhinovirus
2018
1 Citation (Scopus)

Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood

Owens, L., Laing, I. A., Zhang, G., Turner, S. & Le Souëf, P. N., 1 Aug 2018, In : Pediatric Pulmonology. 53, 8, p. 1082-1088 7 p.

Research output: Contribution to journalArticle

Pulmonary Ventilation
Lung
Spirometry
Asthma
Growth
1 Citation (Scopus)
1 Citation (Scopus)

Cellular and molecular mechanisms of vitamin D in food allergy

Poole, A., Song, Y., Brown, H., Hart, P. H. & Zhang, G. B., 1 Jul 2018, In : Journal of Cellular and Molecular Medicine. 22, 7, p. 3270-3277 8 p.

Research output: Contribution to journalReview article

Open Access
Food Hypersensitivity
Vitamin D
Microbiota
Sunlight
DNA Methylation
3 Citations (Scopus)
Open Access
Congenital Heart Defects
MicroRNAs
Atrial Heart Septal Defects
Defects
Cardiovascular Diseases

Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life

Song, Y., Aguilar, R., Guo, J., Manaca, M. N., Nhabomba, A., Berthoud, T. K., Khoo, S. K., Wiertsema, S., Barbosa, A., Quintó, L., Laing, I. A., Mayor, A., Guinovart, C., Alonso, P. L., Lesouëf, P. N., Dobaño, C. & Zhang, G. B., 1 Dec 2018, In : Scientific Reports. 8, 1, 10860.

Research output: Contribution to journalArticle

Open Access
Interleukin-12
Fetal Blood
Malaria
Mothers
Genotype
7 Citations (Scopus)

Cuffed vs. uncuffed tracheal tubes in children: a randomised controlled trial comparing leak, tidal volume and complications

Chambers, N. A., Ramgolam, A., Sommerfield, D., Zhang, G., Ledowski, T., Thurm, M., Lethbridge, M., Hegarty, M. K. & von Ungern-Sternberg, B. S., 1 Feb 2018, In : Anaesthesia. 73, 2, p. 160-168 9 p.

Research output: Contribution to journalArticle

Tidal Volume
Ventilation
Randomized Controlled Trials
Pressure
Mechanical Ventilators
10 Citations (Scopus)
Anesthesia
Randomized Controlled Trials
Propofol
Inhalation Anesthesia
Health Care Costs

PCR screening of antimicrobial resistance genes in faecal samples from Australian and Chinese children

Ravensdale, J. T., Xian, D. T. W., Wei, C. M., Lv, Q., Wen, X., Guo, J., Coorey, R., LeSouëf, P., Lu, F., Zhang, G. & Dykes, G. A., 1 Sep 2018, In : Journal of Global Antimicrobial Resistance. 14, p. 178-181 4 p.

Research output: Contribution to journalArticle

Polymerase Chain Reaction
Genes
Industry
Demography
Tetracycline Resistance
2 Citations (Scopus)

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort

Owens, L., Laing, I. A., Zhang, G., Turner, S. & Le Souëf, P. N., 1 Jan 2018, In : Journal of Asthma and Allergy. 11, p. 173-180 8 p.

Research output: Contribution to journalArticle

Open Access
Seasonal Allergic Rhinitis
Eczema
Asthma
Parturition
Maternity Hospitals
2 Citations (Scopus)

Rhinovirus is the most common virus and rhinovirus-C is the most common species in paediatric intensive care respiratory admissions

Cox, D. W., Khoo, S. K., Zhang, G., Lindsay, K., Keil, A. D., Knight, G., Gern, J. E., Laing, I. A., Bizzintino, J. & Le Souëf, P. N., 1 Aug 2018, In : European Respiratory Journal. 52, 2, 1800207.

Research output: Contribution to journalLetter

2 Citations (Scopus)

The Western environment reduces innate immune cytokine production in Chinese immigrants

Saiganesh, A., Hales, B. J., Chen, S., Filipovska-Naumovska, E., Pereira, G., Garand, M., Kollmann, T. R., Currie, A. J., Le Souëf, P. N. & Zhang, G., 1 Apr 2018, In : Journal of Allergy and Clinical Immunology. 141, p. 1504-1507

Research output: Contribution to journalArticle

2017
4 Citations (Scopus)
75 Downloads (Pure)

Australian Aboriginal children with otitis media have reduced antibody titers to specific nontypeable Haemophilus influenzae vaccine antigens

Thornton, R. B., Kirkham, L. A. S., Corscadden, K. J., Wiertsema, S. P., Fuery, A., Jones, B. J., Coates, H. L., Vijayasekaran, S., Zhang, G., Keil, A. & Richmond, P. C., 1 Apr 2017, In : Clinical and Vaccine Immunology. 24, 4, 10 p., 00556-16.

Research output: Contribution to journalArticle

Open Access
File
Haemophilus Vaccines
Otitis Media
Antigens
Haemophilus influenzae
Antibodies
2 Citations (Scopus)

Can polymorphisms in the fatty acid desaturase (FADS) gene cluster alter the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles? An exploratory study

Meldrum, S. J., Li, Y., Zhang, G., Heaton, A. E. M., D’Vaz, N., Manz, J., Reischl, E., Koletzko, B. V., Prescott, S. L. & Simmer, K., 19 Sep 2017, In : European Journal of Nutrition. p. 1-12 12 p.

Research output: Contribution to journalArticle

Fatty Acid Desaturases
Fish Oils
Multigene Family
Fatty Acids
Erythrocytes

Dual responses of CD14 methylation to distinct environments: a role in asthma and allergy

Song, Y., Khoo, S-K., Lee, K. H., Mäkelä, M., Haahtela, T., LeSouëf, P. & Zhang, G. B., Dec 2017, In : The European Respiratory Journal. 50, 6, 1701228.

Research output: Contribution to journalLetter

EFFECTS OF IN UTERO SMOKE EXPOSURE ON LUNG FUNCTION FROM INFANCY TO ADULTHOOD AND THE CONTRIBUTION OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS

Owens, L., Laing, I., Zhang, G., Murdzoska, J., Turner, S., Mullane, D., Cox, D. & Le Souef, P., Mar 2017, In : Respirology. 22, p. 46-46 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

3 Citations (Scopus)

Environment changes genetic effects on respiratory conditions and allergic phenotypes

Song, Y., Schwager, M. J., Backer, V., Guo, J., Porsbjerg, C., Khoo, S. K., Laing, I. A., Moses, E. K., LeSouëf, P. & Zhang, G., 24 Jul 2017, In : Scientific Reports. 7, 1, 6342.

Research output: Contribution to journalArticle

Open Access
Bronchitis
Phenotype
Single Nucleotide Polymorphism
Population
Genetic Association Studies

Genetic Variants in the IL-4/IL-13 Pathway Influence Measles Vaccine Responses and Vaccine Failure in Children from Mozambique

Clifford, H. D., Hayden, C. M., Khoo, S-K., Naniche, D., Mandomando, I. M., Zhang, G., Richmond, P. & Le Souef, P. N., Sep 2017, In : Viral Immunology. 30, 7, p. 472-478 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Infant lung function predicts asthma persistence and remission in young adults

Owens, L., Laing, I. A., Zhang, G. & Le Souëf, P. N., 1 Feb 2017, In : Respirology. 22, 2, p. 289-294 6 p.

Research output: Contribution to journalArticle

Young Adult
Asthma
Lung
Term Birth
Functional Residual Capacity
1 Citation (Scopus)

Influence of weather on incidence of bronchiolitis in Australia and New Zealand

Hoeppner, T., Borland, M., Babl, F. E., Neutze, J., Phillips, N., Krieser, D., Dalziel, S. R., Davidson, A., Donath, S., Jachno, K., South, M., Williams, A., Zhang, G., Oakley, E. & for the Paediatric Research in Emergency Departments International Collaborative (PREDICT), 1 Oct 2017, In : Journal of Paediatrics and Child Health. 53, 10, p. 1000-1006 7 p.

Research output: Contribution to journalArticle

Bronchiolitis
Weather
New Zealand
Incidence
Temperature
2 Citations (Scopus)

No evidence for impaired humoral immunity to pneumococcal proteins in Australian Aboriginal children with otitis media

Thornton, R. B., Kirkham, L-A. S., Corscadden, K. J., Coates, H. L., Vijayasekaran, S., Hillwood, J., Toster, S., Edminston, P., Zhang, G., Keil, A. & Richmond, P. C., 1 Jan 2017, In : International Journal of Pediatric Otorhinolaryngology. 92, p. 119-125 7 p.

Research output: Contribution to journalArticle

Open Access
Otitis Media
Humoral Immunity
Proteins
Streptococcus pneumoniae
Vaccines
1 Citation (Scopus)

Otitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides

Kirkham, L-A. S., Wiertsema, S. P., Corscadden, K. J., Mateus, T., Mullaney, G. L., Zhang, G., Richmond, P. C. & Thornton, R. B., Mar 2017, In : Clinical and Vaccine Immunology. 24, 3, 11 p., 00497.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
54 Downloads (Pure)

Premedication with salbutamol prior to surgery does not decrease the risk of perioperative respiratory adverse events in school-aged children

Ramgolam, A., Hall, G. L., Sommerfield, D., Slevin, L., Drake-Brockman, T. F. E., Zhang, G. & von Ungern-Sternberg, B. S., 1 Jul 2017, In : British Journal of Anaesthesia. 119, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

Open Access
File
Premedication
Albuterol
Odds Ratio
Confidence Intervals
Placebos
4 Citations (Scopus)

Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco

Annamalay, A. A., Jroundi, I., Bizzintino, J., Khoo, S. K., Zhang, G., Lehmann, D., Laing, I. A., Gern, J., Goldblatt, J., Mahraoui, C., Benmessaoud, R., Moraleda, C., Bassat, Q. & Le Souëf, P., 1 Apr 2017, In : Journal of Medical Virology. 89, 4, p. 582-588 7 p.

Research output: Contribution to journalArticle

Rhinovirus
Morocco
Hospitalized Child
Respiratory Sounds
Pneumonia
27 Citations (Scopus)
127 Downloads (Pure)

The effect of endotracheal tubes versus laryngeal mask airways on perioperative respiratory adverse events in infants: A randomised controlled trial

Drake-Brockman, T. F. E., Ramgolam, A., Zhang, G., Hall, G. L. & von Ungern-Sternberg, B. S., 18 Feb 2017, In : The Lancet. 389, 10070

Research output: Contribution to journalArticle

Open Access
File
Laryngeal Masks
Randomized Controlled Trials
Laryngismus
Bronchial Spasm
Random Allocation
1 Citation (Scopus)

The Implications of DNA Methylation on Food Allergy

Lee, K. H., Song, Y., O'Sullivan, M., Pereira, G., Loh, R. & Zhang, G., 1 Sep 2017, In : International Archives of Allergy and Immunology. 173, 4, p. 183-192 10 p.

Research output: Contribution to journalReview article

Food Hypersensitivity
DNA Methylation
Gene-Environment Interaction
Genetic Loci
Methylation
29 Citations (Scopus)

Vitamin D over the first decade and susceptibility to childhood allergy and asthma

Hollams, E. M., Teo, S. M., Kusel, M., Holt, B. J., Holt, K. E., Inouye, M., De Klerk, N. H., Zhang, G., Sly, P. D., Hart, P. H. & Holt, P. G., Feb 2017, In : Journal of Allergy and Clinical Immunology. 139, 2, p. 472-481.e9

Research output: Contribution to journalArticle

Vitamin D
Hypersensitivity
Asthma
Eczema
Parturition
2016
6 Citations (Scopus)
Open Access
1 Citation (Scopus)

Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique

Annamalay, A. A., Lanaspa, M., Khoo, S-K., Madrid, L., Acacio, S., Zhang, G., Laing, I. A., Gern, J., Goldblatt, J., Bizzintino, J., Lehmann, D., Le Souef, P. N. & Bassat, Q., Sep 2016, In : TROPICAL MEDICINE & INTERNATIONAL HEALTH. 21, 9, p. 1171-1180

Research output: Contribution to journalArticle

Mozambique
Rhinovirus
Hospitalized Child
Pneumonia
Viruses
2015
31 Citations (Scopus)
Open Access
Calcifediol
Adaptive Immunity
Innate Immunity
Pyroglyphidae
Interleukin-5
29 Citations (Scopus)
Open Access
antimicrobial proteins
antimicrobial peptides
Human Milk
breast milk
Premature Infants
9 Citations (Scopus)

Longitudinal assessment of airway responsiveness from 1 month to 18 years in the PIAF birth cohort

Cox, D. W., Mullane, D., Zhang, G., Turner, S. W., Hayden, C., Goldblatt, J., Landau, L. & Le Souëf, P., Dec 2015, In : European Respiratory Journal. 46, 6, p. 1654-1661

Research output: Contribution to journalArticle

Asthma
Parturition
Histamine
Surveys and Questionnaires
2014
25 Citations (Scopus)
107 Downloads (Pure)
Open Access
File
Rhinovirus
Asthma
Antibodies
Infection
Antibody Formation
2 Citations (Scopus)

Serum ferritin and nutritional status: insights from an eating disorders clinic population

Nemba, K., Lewis, B., Watson, H., Hoiles, K., Zhang, B. & Forbes, D., 2014, In : Archives of Disease in Childhood. 99, p. 221-224

Research output: Contribution to journalArticle

2013
1 Citation (Scopus)

Exposure to airborne mould in school environments and nasal patency in children

Zhang, B., Neumeister-Kemp, H., Garrett, M., Kemp, P., Stick, S. & Franklin, P., 2013, In : Indoor and Built Environment. 22, 4, p. 608-617

Research output: Contribution to journalArticle

4 Citations (Scopus)

Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma

Le Page, M. E. L., Goodridge, J. P., Zhang, B., Holt, P., Sly, P. & Witt, C. S., 2013, In : Tissue Antigens. 82, p. 276-279

Research output: Contribution to journalArticle

89 Citations (Scopus)

HRV-C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions

Cox, D. W., Bizzintino, J., Ferrari, G., Khoo, S-K., Zhang, B., Whelan, S., Lee, W. M., Bochkov, Y. A., Geelhoed, G., Goldblatt, J., Gern, J. E., Laing, I. & Le Souef, P., 2013, In : American Journal of Critical Care. 188, 11, p. 1358-1364

Research output: Contribution to journalArticle

Impact of CD14 promoter variants on measles vaccine responses and vaccine failure in children from Australia and Mozambique

Clifford, H., Hayden, C., Khoo, S-K., Naniche, D., Mandomando, I. M., Zhang, B., Richmond, P. & Le Souef, P., 2013, In : Tissue Antigens. 82, p. 420-422

Research output: Contribution to journalReview article

2012
37 Citations (Scopus)

Anti-bacterial antibody reponses associated with the development of asthma in house dust mite-sensitised and non-sensitised children

Hales, B., Chai, L. Y., Elliot, C. E., Pearce, L., Zhang, B., Heinrich, T., Smith, W-A., Kusel, M., Holt, P., Sly, P. & Thomas, W., 2012, In : Thorax. 67, p. 321-327

Research output: Contribution to journalArticle

94 Citations (Scopus)

Cord Blood 25-Hydroxyvitamin D3 and Allergic Disease During Infancy

Jones, A., Palmer, D., Zhang, B. & Prescott, S., 1 Nov 2012, In : Pediatrics. 130, 5, p. 1128-1135

Research output: Contribution to journalArticle

Open Access
Calcifediol
Fetal Blood
Vitamin D
Eczema
Mothers
13 Citations (Scopus)
33 Downloads (Pure)

IgG responses to pneumococcal and haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media

Wiertsema, S., Corscadden, K., Mowe, E., Zhang, B., Vijayasekaran, S., Coates, H., Mitchell, T. J., Thomas, W., Richmond, P. & Kirkham, L-A., 12 Dec 2012, In : PLoS One. 7, 11, p. e49061

Research output: Contribution to journalArticle

Open Access
File
otitis media
Haemophilus influenzae
Otitis Media
Immunoglobulin G
antigens
7 Citations (Scopus)
9 Citations (Scopus)

Neonatal protein kinase C zeta expression determines the neonatal T-Cell cytokine phenotype and predicts the development and severity of infant allergic disease

D'Vaz, N., Ma, Y., Dunstan, J., Lee-Pullen, T., Hii, C., Meldrum, S., Zhang, B., Metcalfe, J., Ferrante, A. & Prescott, S., 1 Dec 2012, In : Allergy. 67, 12, p. 1511-1518

Research output: Contribution to journalArticle

Open Access
Child Development
Cytokines
T-Lymphocytes
Phenotype
Fetal Blood
16 Citations (Scopus)

Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from Mozambique

Clifford, H., Hayden, C., Khoo, S-K., Naniche, D., Mandomando, I. M., Zhang, B., Richmond, P. & Le Souef, P., 21 Sep 2012, In : Vaccine. 30, 43, p. 6180-6185

Research output: Contribution to journalArticle

Mozambique
Measles Vaccine
Measles
Vaccines
genetic polymorphism
12 Citations (Scopus)

Prevalence of and risk factors for human rhinovirus infection in healthy aboriginal and non-aboriginal western australian children

Annamalay, A., Khoo, S-K., Jacoby, P., Bizzintino, J., Zhang, B., Chidlow, G., Lee, W-M., Moore, H., Harnett, G. B., Smith, D., Gern, J. E., Le Souef, P., Laing, I. & Lehmann, D., 2012, In : Pediatric Infectious Disease Journal. 31, 7, p. 673-679

Research output: Contribution to journalArticle

14 Citations (Scopus)
15 Citations (Scopus)

TLR3 and RIG-I gene variants: Associations with functional effects on receptor expression and responses to measles virus and vaccine in vaccinated infants

Clifford, H., Yerkovich, S. T., Khoo, S-K., Zhang, B., Upham, J., Le Souëf, P. N., Richmond, P. & Hayden, C., 2012, In : Human Immunology. 73, 6, p. 677-685

Research output: Contribution to journalArticle

2011
198 Citations (Scopus)

Association between human rhinovirus C and severity of acute asthma in children

Bizzintino, J. A., Lee, W-M., Laing, I., Vang, F., Pappas, T., Zhang, B., Martin, A. C., Geelhoed, G., Mcminn, P. C., Goldblatt, J., Gern, J. E. & Le Souef, P., 2011, In : European Respiratory Journal. DOI: 10.1183/09031936.00092410, p. N/A

Research output: Contribution to journalArticle