Research output per year
Research output per year
Personal profile
Biography
Dr. Ben Wylie completed his PhD, focused on immunology and cancer immunotherapy, at the Telethon Kids Institute and University of Western Australia in 2018. He has more than 10 years’ experience, working across both academic and industry-based cancer research and is currently a Cancer Council WA post-doctoral fellow, working with the Sarcoma Research Group in the Cancer Centre at Telethon Kids Institute.
His research seeks to develop kinder and more effective treatments for children and young adults with solid tumours, with a particular focus on Sarcoma, the third most common paediatric cancer. To do this, Ben is combining his expertise in cancer immunology with the rapidly growing field of mRNA therapeutics to develop local treatment strategies which take advantage of the surgical‘window of opportunity’. His work sits at the interface of immunology and oncology with a focus onnovel therapeutics and delivery technologies.
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Collaborations and top research areas from the last five years
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Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade
Principe, N., Phung, A. L., Stevens, K. L. P., Elaskalani, O., Wylie, B., Tilsed, C. M., Sheikh, F., Orozco Morales, M. L., Kidman, J., Marcq, E., Fisher, S. A., Nowak, A. K., McDonnell, A. M., Lesterhuis, W. J. & Chee, J., 28 Sept 2024, In: Journal for immunotherapy of cancer. 12, 9, 15 p., e008568.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)39 Downloads (Pure) -
Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade
Rwandamuriye, F. X., Wang, T., Zhang, H., Elaskalani, O., Kuster, J., Ye, X., Vitali, B., Schreurs, J., Orozco Morales, M. L., Norret, M., Evans, C. W., Zemek, R. M., Iyer, K. S., Lesterhuis, W. J. & Wylie, B., Aug 2024, In: OncoImmunology. 13, 1, 10 p., 2395067.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Protocol for delivery of intraoperative immunotherapy to mice by surgical debulking of subcutaneous tumors
Rwandamuriye, F. X., Vitali, B., Schreurs, J., Wang, T., Barrick, E., Iyer, K. S., Lesterhuis, W. J., Zemek, R. M. & Wylie, B., 21 Jun 2024, In: STAR Protocols. 5, 2, 102948.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence
Rwandamuriye, F. X., Evans, C. W., Wylie, B., Norret, M., Vitali, B., Ho, D., Nguyen, D., Roper, E. A., Wang, T., Hepburn, M. S., Sanderson, R. W., Pfirrmann, M., Fear, V. S., Forbes, C. A., Wyatt, K., Ryan, A. L., Johns, T. G., Phillips, M. B., Hodder, R. & Leslie, C. & 4 others, , 18 Jul 2023, In: Cell Reports Medicine. 4, 7, 101113.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice
Zemek, R., Chin, M., Fear, V., Wylie, B., Casey, T., Forbes, C., Tilsed, C., Boon, L., Guo, B., Bosco, A., Forrest, A., Millward, M., Nowak, A., Lake, R., Lassmann, T. & Lesterhuis, W., Dec 2022, In: Nature Communications. 13, 1, 4895.Research output: Contribution to journal › Article › peer-review
Open Access32 Citations (Scopus)
Projects
- 3 Finished
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Core infrastructure: high-throughput nanodrop spectrophotometer
Kretzmann, J. (Investigator 01), Evans, C. (Investigator 02), Choi, Y. S. (Investigator 03), Waryah, C. (Investigator 04), Sarkar-Tyson, M. (Investigator 05), Wang, T. (Investigator 06), Bond, C. (Investigator 07), Vrielink, A. (Investigator 08), Smith, N. (Investigator 09), Lesterhuis, W. (Investigator 10), Marshall, A. (Investigator 11), Stubbs, K. (Investigator 12), Deane, K. (Investigator 13), Chen, K. (Investigator 14), Smithers, L. (Investigator 15), Wylie, B. (Investigator 16), Wang, E. (Investigator 17) & Blancafort, P. (Investigator 18)
NHMRC National Health and Medical Research Council
15/03/24 → 31/12/24
Project: Research
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RNA immunotherapy to prevent local relapse
Wylie, B. (Investigator 01), Zemek, R. (Investigator 02) & Wang, T. (Investigator 03)
1/03/23 → 1/09/24
Project: Research
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A phase I veterinary trial of an immunotherapy gel to prevent cancer relapse after sarcoma surgery
Swaminatha Iyer, I. (Investigator 01), Lesterhuis, W. (Investigator 02), Wyatt, K. (Investigator 03) & Wylie, B. (Investigator 04)
Children’s Leukaemia and Cancer Research Foundation
14/03/22 → 14/03/23
Project: Research