Belinda Hales

Dr

  • The University of Western Australia (M561), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1836 Citations
  • 24 h-Index
19952019
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Research Output 1995 2019

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Article
2019

Effects of Ser47-point mutation on conformation structure and allergenicity of the allergen of Der p 2, a major house dust mite allergen

Kulwanich, B., Thanyaratsrisakul, S., Jirapongsananuruk, O., Hales, B. J., Thomas, W. R. & Piboonpocanun, S., 1 Jan 2019, In : Allergy, Asthma and Immunology Research. 11, 1, p. 129-142 14 p.

Research output: Contribution to journalArticle

Open Access
Dermatophagoides Antigens
Point Mutation
Immunoglobulin E
Pyroglyphidae
Blocking Antibodies
2018
6 Citations (Scopus)

Clinical significance of circulating microRNAs as markers in detecting and predicting congenital heart defects in children

Song, Y., Higgins, H., Guo, J., Harrison, K., Schultz, E. N., Hales, B. J., Moses, E. K., Goldblatt, J., Pachter, N. & Zhang, G., 27 Feb 2018, In : Journal of Translational Medicine. 16, 1, 42.

Research output: Contribution to journalArticle

Open Access
Congenital Heart Defects
MicroRNAs
Atrial Heart Septal Defects
Defects
Cardiovascular Diseases
1 Citation (Scopus)

T-cell responses against rhinovirus species A and C in asthmatic and healthy children

Gaido, C. M., Granland, C., Laing, I. A., Souëf, P. N. L., Thomas, W. R., Currie, A. J. & Hales, B. J., 1 Mar 2018, In : Immunity Inflammation and Disease. 6, 1, p. 143-153 11 p.

Research output: Contribution to journalArticle

Open Access
Rhinovirus
T-Lymphocytes
Asthma
Infection
Regulatory T-Lymphocytes
3 Citations (Scopus)

The Western environment reduces innate immune cytokine production in Chinese immigrants

Saiganesh, A., Hales, B. J., Chen, S., Filipovska-Naumovska, E., Pereira, G., Garand, M., Kollmann, T. R., Currie, A. J., Le Souëf, P. N. & Zhang, G., 1 Apr 2018, In : Journal of Allergy and Clinical Immunology. 141, p. 1504-1507

Research output: Contribution to journalArticle

2016
25 Citations (Scopus)
137 Downloads (Pure)

Distinguishing benign from pathologic TH2 immunity in atopic children

Holt, P., Strickland, D., Bosco, A., Belgrave, D., Hales, B., Simpson, A., Hollams, E., Holt, B., Kusel, M., Ahlstedt, S., Sly, P. D. & Custovic, A., Feb 2016, In : Journal of Allergy and Clinical Immunology. 137, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

Open Access
File
Immunity
Immunoglobulin E
Immunoglobulin G
Allergens
Asthma
4 Citations (Scopus)

Effect of amino acid polymorphisms of house dust mite Der p 2 variants on allergic sensitization

Tanyaratsrisakul, S., Jirapongsananuruk, O., Kulwanich, B., Hales, B., Thomas, W. & Piboonpocanun, S., 2016, In : Allergy, Asthma and Immunology Research. 8, 1, p. 55-62

Research output: Contribution to journalArticle

Open Access
Pyroglyphidae
Immunoglobulin E
Amino Acids
Inhibitory Concentration 50
Antibody Specificity
7 Citations (Scopus)

Immunodominant T-cell epitopes in the VP1 capsid protein of rhinovirus species A and C

Gaido, C., Stone, S., Chopra, A., Thomas, W. R., Le Souef, P. N. & Hales, B. J., 2016, In : Journal of Virology. 90, 23, p. 10459-10471 13 p.

Research output: Contribution to journalArticle

Rhinovirus
Immunodominant Epitopes
Enterovirus
Rhinovirus C
T-Lymphocyte Epitopes
5 Citations (Scopus)
2015
11 Citations (Scopus)

Analysis of ige binding patterns to house dust mite allergens in scabies-endemic communities: Insights for both diseases

Walton, S. F., Slender, A., Pizutto, S., Mounsey, K. E., Opresecu, F., Thomas, W., Hales, B. & Currie, B. J., 2015, In : Clinical and Experimental Allergy. 45, 12, p. 1868-1872

Research output: Contribution to journalArticle

21 Citations (Scopus)

A role for CCL28-CCR3 in T-cell homing to the human upper airway mucosa

Danilova, E., Skrindo, I., Gran, E., Hales, B., Smith, W. A., Jahnsen, J., Johansen, F. E., Jahnsen, F. L. & Baekkevold, E. S., 2015, In : Mucosal Immunology. 8, 1, p. 107-114

Research output: Contribution to journalArticle

Mucous Membrane
T-Lymphocytes
Nasal Mucosa
Chemokine Receptors
Chemokines
20 Citations (Scopus)

Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization

Renand, A., Archila, L. D., Mcginty, J., Wambre, E., Robinson, D., Hales, B., Thomas, W. & Kwok, W. W., 2015, In : Journal of Allergy and Clinical Immunology. 136, 6, p. 1627-1635.e13

Research output: Contribution to journalArticle

Allergens
Cats
Immunoglobulin G
Hypersensitivity
Ownership
2 Citations (Scopus)

Developments in the field of allergy in 2014 through the eyes of Clinical and Experimental Allergy

Hales, B., Hizawa, N., Jenmalm, M., Sverremark-Ekström, E. & Wardlaw, A. J., 2015, In : Clinical and Experimental Allergy. 45, 12, p. 1723-1745

Research output: Contribution to journalArticle

Hypersensitivity
Asthma
Allergens
Biomarkers
Inborn Genetic Diseases

Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniae

Anderson, D., Fakiola, M., Hales, B., Pennell, C., Thomas, W. & Blackwell, J., Jul 2015, In : Genes and Immunity. 16, 5, p. 289-296 8 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
HLA Antigens
Choline
Streptococcus pneumoniae
Protein C
24 Citations (Scopus)

Improving immunity to Haemophilus influenzae in children with chronic suppurative lung disease

Pizzutto, S., Yerkovich, S. T., Upham, J. W., Hales, B., Thomas, W. & Chang, A. B., 2015, In : Vaccine. 33, 2, p. 321-326

Research output: Contribution to journalArticle

Haemophilus influenzae
respiratory tract diseases
Lung Diseases
Immunity
immunity
5 Citations (Scopus)

Lower anti-echovirus antibody responses in children presenting to hospital with asthma exacerbations

Iwasaki, J., Chai, L., Khoo, S-K., Bizzintino, J., Laing, I., Le Souef, P., Thomas, W. & Hales, B., 15 Sep 2015, In : Clinical and Experimental Allergy. 45, 10, p. 1523-1530 8 p.

Research output: Contribution to journalArticle

Human Enterovirus B
Antibody Formation
Anti-Idiotypic Antibodies
Poliovirus
Asthma
244 Citations (Scopus)

The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development

Teo, S. M., Mok, D., Pham, K., Kusel, M., Serralha, M., Troy, N., Holt, B. J., Hales, B., Walker, M. L., Hollams, E., Bochkov, Y. A., Grindle, K., Johnston, S. L., Gern, J. E., Sly, P. D., Holt, P., Holt, K. E. & Inouye, M., 2015, In : Cell Host and Microbe. 17, 5, p. 704-715

Research output: Contribution to journalArticle

Open Access
Nasopharynx
Microbiota
Respiratory Tract Infections
Asthma
Moraxella
2014
26 Citations (Scopus)

Children with chronic suppurative lung disease have a reduced capacity to synthesize interferon-gamma in vitro in response to non-typeable Haemophilus influenzae

Pizzutto, S., Yerkovich, S. T., Upham, J. W., Hales, B., Thomas, W. & Chang, A. B., 11 Aug 2014, In : PLoS One. 9, 8, 10 p., e104236.

Research output: Contribution to journalArticle

Open Access
Haemophilus influenzae
Pulmonary diseases
interferon-gamma
respiratory tract diseases
Lung Diseases
25 Citations (Scopus)
136 Downloads (Pure)
Open Access
File
Rhinovirus
Asthma
Antibodies
Infection
Antibody Formation
28 Citations (Scopus)

Defective respiratory tract immune surveillance in asthma: a primary causal factor in disease onset and progression

Holt, P. G., Strickland, D. H., Hales, B. J. & Sly, P. D., Feb 2014, In : Chest. 145, 2, p. 370-378 9 p.

Research output: Contribution to journalArticle

Open Access
2013
9 Citations (Scopus)

IgE and IgG Binding Patterns and T-cell Recognition of Fel d 1 and Non-Fel d 1 Cat Allergens

Hales, B., Chai, L. Y., Hazell, L., Elliot, C. E., Stone, S., O'Neil, S., Smith, W-A. & Thomas, W., 2013, In : Journal of Allergy and Clinical Immunology: In Practice. 1, 6, p. 656-665

Research output: Contribution to journalArticle

12 Citations (Scopus)
Open Access
Rhinovirus C
Rhinovirus A
Human rhinovirus
Rhinovirus
viral proteins
2012
37 Citations (Scopus)

Anti-bacterial antibody reponses associated with the development of asthma in house dust mite-sensitised and non-sensitised children

Hales, B., Chai, L. Y., Elliot, C. E., Pearce, L., Zhang, B., Heinrich, T., Smith, W-A., Kusel, M., Holt, P., Sly, P. & Thomas, W., 2012, In : Thorax. 67, p. 321-327

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effect of early carriage of streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancy

Van Den Biggelaar, A., Pomat, W. S., Phuanukoonnon, S., Michael, A., Aho, C., Nadal-Sims, M. A., Devitt, C. J., Jacoby, P., Hales, B., Smith, W-A., Mitchell, T., Wiertsema, S., Richmond, P., Siba, P., Holt, P. & Lehmann, D., 2012, In : Pediatric Infectious Disease Journal. 31, 3, p. 243-48

Research output: Contribution to journalArticle

17 Citations (Scopus)

Quantitation of IgE Binding to the Chitinase and Chitinase-Like House Dust Mite Allergens Der p 15 and Der p 18 Compared to the Major and Mid-Range Allergens

Hales, B., Elliot, C. E., Chai, L. Y., Pearce, L. J., Tipayanon, T., Hazell, L., Stone, S., Piboonpocanun, S., Thomas, W. & Smith, W-A., 2012, In : International Archives of Allergy and Immunology. 160, 3, p. 233-240

Research output: Contribution to journalArticle

18 Citations (Scopus)

Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive pulmonary disease requiring hospitalisation

Yerkovich, S. T., Hales, B., Carroll, M. L., Burel, J. G., Towers, M. A., Smith, D. J., Thomas, W. & Upham, J. W., 2012, In : BMC Pulmonary Medicine. 12, 37, p. 1-7

Research output: Contribution to journalArticle

Open Access
2011
35 Citations (Scopus)

A diagnostic test for scabies: IgE specificity for a recombinant allergen of Sarcoptes scabiei

Jayaraj, R., Hales, B., Viberg, L., Pizzuto, S., Holt, D., Rolland, J. M., O'Hehir, R. E., Currie, B. J. & Walton, S. F., 2011, In : Diagnostic Microbiology and Infectious Disease. 71, 4, p. 403-407

Research output: Contribution to journalArticle

40 Citations (Scopus)

Two newly identified cat allergens: The von Ebner gland protein Fel d 7 and the latherin-like protein Fel d 8

Smith, W-A., O'Neil, S. E., Hales, B., Chai, T. L. Y., Hazell, L. A., Tanyaratsrisakul, S., Piboonpocanum, S. & Thomas, W., 2011, In : International Archives of Allergy and Immunology. 156, 2, p. 159-170

Research output: Contribution to journalArticle

7 Citations (Scopus)

Using Time-Resolved Fluorescence to Measure Serum Venom-Specific IgE and IgG

Van Eeden, P., Wiese, M. D., Aulfrey, S., Hales, B., Stone, S. & Brown, S., 2011, In : PLoS One. 6, 1, p. 8 pages

Research output: Contribution to journalArticle

Open Access
2010
51 Citations (Scopus)

Increased Allergic Immune Response to Sarcoptes scabiei Antigens in Crusted versus Ordinary Scabies

Walton, S. F., Pizzutto, S., Slender, A., Viberg, L., Holt, D., Hales, B., Kemp, D. J., Currie, B. J., Rolland, J. M. & O'Hehir, R., 2010, In : Clinical and Vaccine Immunology. 17, p. 1428-1438

Research output: Contribution to journalArticle

57 Citations (Scopus)

Th2-associated immunity to bacteria in teenagers and susceptibility to asthma

Hollams, E., Hales, B., Bachert, C., Huvenne, W., Parsons, F., De Klerk, N., Serralha, M., Holt, B., Ahlstedt, S., Thomas, W., Sly, P. & Holt, P., 2010, In : European Respiratory Journal. 36, 3, p. 509-516

Research output: Contribution to journalArticle

2009
29 Citations (Scopus)

Anit-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation

Hales, B., Martin, A. C., Pearce, L. J., Rueter, K., Zhang, B., Khoo, S-K., Hayden, C., Bizzintino, J., Mcminn, P., Geelhoed, G., Lee, W-M., Goldblatt, J., Laing, I., Le Souef, P. & Thomas, W., 2009, In : Clinical and Experimental Allergy. 39, 8, p. 1170-1178

Research output: Contribution to journalArticle

120 Citations (Scopus)

House Dust Mite Sublingual Immunotherapy : the Role for Transforming Growth Factor–β and Functional Regulatory T Cells

O'Hehir, R. E., Gardner, L. M., De Leon, M. P., Hales, B., Biondo, M., Douglass, J. A., Rolland, J. M. & Sandrini, A., 2009, In : American Journal of Respiratory and Critical Care Medicine. 180, 10, p. 936-947

Research output: Contribution to journalArticle

Sublingual Immunotherapy
Pyroglyphidae
Transforming Growth Factors
Regulatory T-Lymphocytes
Immunotherapy
150 Citations (Scopus)

Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children

Subrata, L. S., Bizzintino, J. A., Mamessier, E., Bosco, A., Mckenna, K., Wikstrom, M., Goldblatt, J., Sly, P., Hales, B., Thomas, W., Laing, I., Le Souef, P. & Holt, P., 2009, In : Journal of Immunology. 183, 4, p. 2793-2800

Research output: Contribution to journalArticle

Interleukin-13
Virus Diseases
Allergens
Antiviral Agents
Monocytes
2008
21 Citations (Scopus)

Differences in the antibody response to a mucosal bacterial antigen between allergic and non-allergic subjects

Hales, B., Pearce, L. J., Kusel, M., Holt, P., Sly, P. & Thomas, W., 2008, In : Thorax. 63, 3, p. 221-227

Research output: Contribution to journalArticle

Bacterial Antigens
Antibody Formation
Immunoglobulin G
Skin Tests
Immunoglobulin E

Immune responses to inhalant allergens

Thomas, W. & Hales, B., 2008, In : The World Allergy Organization Journal. June, na, p. 89-95

Research output: Contribution to journalArticle

2007
46 Citations (Scopus)

Pyroglyphid house dust mite allergens

Thomas, W., Heinrich, T., Smith, W-A. & Hales, B., 2007, In : Protein and Peptide Letters. 14, p. 943-953

Research output: Contribution to journalArticle

Dermatophagoides Antigens
Allergens
Genetic engineering
Pyroglyphidae
Genetic Engineering
19 Citations (Scopus)

T and B cell responses to HDM allergens and antigens

Thomas, W. & Hales, B., 2007, In : Immunologic Research. 37, 3, p. 187-199

Research output: Contribution to journalArticle

Allergens
B-Lymphocytes
T-Lymphocytes
Antigens
Immunoglobulin G
2006
2 Citations (Scopus)

Determinants of house dust mite allergenicity

Hales, B., Chu, N. R., Bosco, A., Smith, W-A., Heinrich, T. & Thomas, W., 2006, In : Allergy & clinical immunology international-journal of the world allergy organization. 18, 2, p. 65-70

Research output: Contribution to journalArticle

Pyroglyphidae
Allergens
Immunoglobulin E
Dermatophagoides Antigens
Mites
108 Citations (Scopus)

IgE and IgG anti-house dust mite specificities in allergic disease

Hales, B., Martin, A. C., Pearce, L. J., Laing, I., Hayden, C., Goldblatt, J., Le Souef, P. & Thomas, W., 2006, In : Journal of Allergy and Clinical Immunology. 118, 2, p. 361-367

Research output: Contribution to journalArticle

Pyroglyphidae
Immunoglobulin G
Antibodies
Immunoglobulin E
Hospital Emergency Service
48 Citations (Scopus)

The chitinase allergens Der p 15 and Der p 18 from Dermatophagoides pteronyssinus

O'Neil, S. E., Heinrich, T., Hales, B., Hazell, L. A., Holt, D. C., Fischer, K. & Thomas, W., 2006, In : Clinical and Experimental Allergy. 36, 6, p. 831-839

Research output: Contribution to journalArticle

Dermatophagoides pteronyssinus
Chitinases
Allergens
Immunoglobulin E
Dermatophagoides farinae
2005
15 Citations (Scopus)

Genetically engineered vaccaines

Thomas, W., Hales, B. & Smith, W-A., 2005, In : Current Allergy and Asthma Reports. 5, 3, p. 197-203

Research output: Contribution to journalArticle

Allergens
B-Lymphocyte Epitopes
Vaccines
T-Lymphocytes
Immunoglobulin E
64 Citations (Scopus)

Structural biology of allergens

Thomas, W., Hales, B. & Smith, W-A., 2005, In : Current Allergy and Asthma Reports. 5, 5, p. 388-393

Research output: Contribution to journalArticle

Toll-Like Receptors
Allergens
CD-I
Ligands
Lipids
2001
54 Citations (Scopus)

Allergens of wild house dust mites: environmental Der p 1 and Der p 2 sequence polymorphisms

Smith, W. A., Hales, B., Jarnicki, A. G. & Thomas, W. R., 2001, In : Journal of Allergy and Clinical Immunology. 107, p. 985-992

Research output: Contribution to journalArticle

Dermatophagoides Antigens
Mites
Allergens
Complementary DNA
Clone Cells
2000
25 Citations (Scopus)
36 Citations (Scopus)

Cytokine responses to Der p 1 and Der p 7: house dust mite allergens with different IgE-binding activities

Hales, B., Shen, H-D. & Thomas, W. R., 2000, In : Clinical and Experimental Allergy. 30, p. 934-943

Research output: Contribution to journalArticle

Dermatophagoides Antigens
Allergens
Immunoglobulin E
Interleukin-5
Cytokines
1998
7 Citations (Scopus)

Allergens - sequence diversity and T-cell recognition

Thomas, W. R., Smith, W-A. & Hales, B., 1998, In : Allergic and Clinical Immunology International. 10, p. 16-22

Research output: Contribution to journalArticle

1997
38 Citations (Scopus)
Dermatophagoides pteronyssinus
Pyroglyphidae
Epitopes
T-Lymphocytes
Peptides
1995
118 Citations (Scopus)

Inhalant allergen-specific T cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium

Upham, J. W., Holt, B. J., Baron-Hay, M. J., Yabuhara, A., Hales, B., Thomas, W. R., Loh, R. K. S., O'Keefe, P., Palmer, L., Lesouef, P., Sly, P. D., Burton, P. R., Robinson, B. & Holt, P. G., 1995, In : Clinical and Experimental Allergy. 25, p. 634-642

Research output: Contribution to journalArticle

Serum-Free Culture Media
Allergens
T-Lymphocytes
Serum
Antigens