• The University of Western Australia (M519), 35 Stirling Highway,

    6009 Perth

    Australia

  • 331 Citations
  • 7 h-Index
20122019
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Personal profile

Biography

I completed my BSc Honours degree at the University of Canterbury in Christchurch, New Zealand, where I generated and characterised a mutant DHDPS (dihydrodipicolinate synthase) protein, which is a rate-limiting enzyme in lysine biosynthesis.

I completed my PhD degree at the University of Melbourne in 2014, where I investigated the role of exosomes (small membrane-bound vesicles released by cells) in prion disease. I used a range of molecular and cell biology techniques to examine how different cellular pathways regulate exosome formation, packaging of the prion protein, release from cells and subsequent intercellular transmission of prion infectivity.

I worked as a Research Assistant at the Bio21 Institute, University of Melbourne, where I undertook my PhD studies. I assisted with several projects, including continuations of my PhD project. In addition, I received training for and worked on next-generation sequencing (NGS) projects using the Ion Torrent Personal Genome Machine (PGM) platform.

I joined the Translational Cancer Pathology Laboratory in 2014, where I will apply my molecular and NGS skills to cancer research, with a focus on molecular genomic studies of melanoma, glioma and haematological malignancies.

Previous positions

Research Assistant, University of Melbourne, VIC, Australia

Research

Molecular genomic studies of haematological malignancies including myelodysplastic syndrome (MDS) and myeloproliferative neoplasm (MPN).

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 6 Similar Profiles
Prions Medicine & Life Sciences
Megakaryocytes Medicine & Life Sciences
Exosomes Medicine & Life Sciences
Hyperplasia Medicine & Life Sciences
Mutation Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Prion Diseases Medicine & Life Sciences
Sphingomyelin Phosphodiesterase Medicine & Life Sciences

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Projects 2015 2019

Research Output 2012 2018

  • 331 Citations
  • 7 h-Index
  • 11 Article
  • 1 Abstract/Meeting Abstract
  • 1 Letter

Automated enumeration of lymphoid and plasma cells in bone marrow to establish normal reference ranges

Liang, J., Malherbe, J. A. J., Fuller, K. A., Mirzai, B., George, C., Carter, T. L., Cole, C. H., Guo, B. B., Meehan, K. & Erber, W. N., 1 Oct 2018, In : Journal of Clinical Pathology. 71, 10, p. 916-925 10 p.

Research output: Contribution to journalArticle

Plasma Cells
Reference Values
Bone Marrow
Lymphocytes
Biopsy

A mutation in PTPN11 may drive leukemic transformation in a case of essential thrombocythemia

Guo, B., Liang, J., Allcock, R., Mirzai, B., Augustson, B., Howman, R., Fuller, K. & Erber, W., 7 Jun 2017, In : LEUKEMIA & LYMPHOMA. 59, 1, p. 245-248

Research output: Contribution to journalLetter

Detection of therapeutic targets in carcinomas of unknown primary

Clynick, B., Dessauvagie, B., Strerrett, G., Harvey, N., Subramaniam, S., Herron, J., Allcock, R., Guo, B., Saunder, C., Erber, W. & Meehan, K., Sep 2017, In : Annals of Oncology. 28, 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Megakaryocytes in myeloproliferative neoplasms have unique somatic mutations

Guo, B. B., Allcock, R. J., Mirzai, B., Malherbe, J. A., Choudry, F. A., Frontini, M., Chuah, H., Liang, J., Kavanagh, S. E., Howman, R., Ouwehand, W. H., Fuller, K. A. & Erber, W., Jul 2017, In : The American Journal of Pathology. 187, 7, p. 1512–1522

Research output: Contribution to journalArticle

Megakaryocytes
Mutation
Primary Myelofibrosis
Bone Marrow
Neoplasms
3 Citations

Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms

Malherbe, J., Fuller, K., Mirzai, B., Kavanagh, S., So, C. C., Ip, H. W., Guo, B., Forsyth, C., Howman, R. & Erber, W., 2016, In : Journal of Clinical Pathology. 69, 11, p. 1017-1024

Research output: Contribution to journalArticle

Open Access
Megakaryocytes
Hyperplasia
Caspase 9
Primary Myelofibrosis
Neoplasms