Barry Marshall

Professor, MB BS W.Aust., FRACP, FRS, FAA

  • The University of Western Australia (M504), 35 Stirling Highway, Room 2.14, L Block, QEII Medical Centre, Nedlands

    6009 Perth

    Australia

  • 1445 Citations
  • 21 h-Index
1989 …2020
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Personal profile

Biography

Prof. Barry Marshall has managed a Helicobacter pylori research group almost since his discovery of Helicobacter pylori with Robin Warren in 1982. Prof. Marshall has received many honors for his work on Helicobacter pylori, most notably they include, the Nobel Prize for Medicine or Physiology in 2005, The William Beaumont Prize in 2006 (American Gastroenterology Association), in 1995 the Albert Lasker Award (Albert & Mary Lasker Foundation), and in 1998 the Dr. A. H. Heineken Prize for Medicine (The Alfred Heineken Foundation, Amsterdam). In 2007 Prof. Marshall was awarded the honour of Western Australian of the year and The Companion in the General Division of the Order of Australia (AC). Prof. Marshall holds professional memberships with the Australian Academy of Science, the British Royal Society, the Institute of Medicine (USA), the American Gastroenterological Association, the Australian Gastroenterological Society and the Australian Medical Association to name a few.

In the past few years Prof. Marshall’s laboratory has developed enhanced methods for non-invasive studies on the molecular epidemiology of H. pylori, notably rapid breath test methods and retrieval of the organism (and culture) from a swallowed string. The H. pylori laboratory has produced seven Microbiology Honors graduates and currently has one Honors and three PhD candidates enrolled. Prof. Marshall has also recently succeeded in drawing investor funding from international and national sources for the creation of Ondek; a small biotech company focused on developing new biologic delivery systems for vaccines and therapeutics, utilizing the unique characteristics of genetically modified Helicobacter pylori.

Roles and responsibilities

• Ambassador for Life Sciences for Western Australia
• Clinical Professor of Medicine and Microbiology, UWA
• Director of the Marshall Centre for Infectious Diseases Research & Training, UWA
• Consultant Gastroenterologist, Sir Charles Gairdner Hospital
• Founder and Director of ONDEK, a biotechnology company
• Founder and Director of TRI-MED, a diagnostics company
• Member, Western Australian Technology and Industry Advisory Council
• Honorary Patron of Scitech, the Ear Science Institute and Fremantle Hospital Medical Research Foundation
• Honorary Patron of Warren Jones Institute for Community Health and Medical Research at Fiona Stanley Hospital

Future research

• Basic and applied medical research in Helicobacter
• Genomics and the evolution of Helicobacter
• Expert Patient Treatment System (EPTS) software application
• Establishment of a Helicobacter culture collection with linked genome and clinical data (e-bio bank)

Research

Profiling antibiotic resistance in H. pylori
Testing novel antibiotic compounds on H. pylori clinical isolates
Monitoring the cure rate of quadruple therapies against multi-drug resistant H. pylori strains
Genomic sequencing and analysis of bacterial genomes
The evolution of Helicobacter species
H. pylori toxin and regulatory genes
The effects of H. pylori on the immune system

Keywords

  • Antibiotic resistance in helicobacter pylori
  • Novel therapies to treat helicobacter pylori
  • Development of a treatment software application
  • Helicobacter genomics and evolution
  • Helicobacter pylori toxin and regulatory genes

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Projects 1998 2020

Research Output 1989 2018

Acoustic signal processing
Acoustics
Acoustic waves
Learning systems
Stethoscopes

A mathematical model of bowel sound generation

Du, X., Allwood, G., Webberley, K., Osseiran, A., Wan, W., Volikova, A. & Marshall, B., 3 Dec 2018, In : The Journal of the Acoustical Society of America. 144, EL485

Research output: Contribution to journalArticle

mathematical models
acoustics
damping
Mathematical Model
Sound
Open Access
Acoustics
Acoustic waves
Costs and Cost Analysis
acoustics
sensors

Lipopolysaccharide structural differences between western and Asian Helicobacter pylori strains

Li, H., Tang, H., Debowski, A. W., Stubbs, K. A., Marshall, B. J. & Benghezal, M., 8 Sep 2018, In : Toxins. 10, 9, 364.

Research output: Contribution to journalReview article

Open Access
Helicobacter pylori
Lipopolysaccharides
O Antigens
Glucans
Oligosaccharides

The potential of computerised analysis of bowel sounds for diagnosis of gastrointestinal conditions: A systematic review

Inderjeeth, A. J., Webberley, K. M., Muir, J. & Marshall, B. J., 17 Aug 2018, In : Systematic Reviews. 7, 1, 124.

Research output: Contribution to journalArticle

Open Access
Routine Diagnostic Tests
Predictive Value of Tests
Biomedical Engineering
Clinical Competence
Ileus

Prizes

2018 WA IOTY Emerging Innovation Category Winners

Josephine Muir (Recipient), Barry Marshall (Recipient), Katherine Webberley (Recipient) & Xuhao Du (Recipient), 7 Nov 2018

Prize/award: Prize

Innovation
Innovators