Arunasalam Dharmarajan

Emeritus Professor, MSc Madras, MMedSc Sri Lanka, PhD W.Aust.

  • The University of Western Australia (M309), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1968 Citations
  • 27 h-Index
19942019
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Research Output 1994 2019

2019
Neoplastic Stem Cells
Stem cells
Mesenchymal Stromal Cells
Breast Neoplasms
Neoplasms
1 Citation (Scopus)

Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma

Bhuvanalakshmi, G., Gamit, N., Patil, M., Arfuso, F., Sethi, G., Dharmarajan, A., Kumar, A. P. & Warrier, S., Jan 2019, In : Cancers. 11, 1, 20 p., 25.

Research output: Contribution to journalArticle

Open Access
2018

Colon cancer chemoresistance and chemosensitization

Shanmugam, M. K., Dharmarajan, A., Arfuso, F. & Sethi, G., 13 Feb 2018, Cancer Cell Chemoresistance And Chemosensitization. World Scientific Publishing, p. 181-226 46 p.

Research output: Chapter in Book/Conference paperChapter

6 Citations (Scopus)

Granulosa cell apoptosis in the ovarian follicle-A changing view

Regan, S. L. P., Knight, P. G., Yovich, J. L., Leung, Y., Arfuso, F. & Dharmarajan, A., 2 Mar 2018, In : Frontiers in Endocrinology. 9, MAR, 61.

Research output: Contribution to journalReview article

Open Access
Ovarian Follicle
Granulosa Cells
Apoptosis
Oocytes
Pregnancy Rate
2 Citations (Scopus)
Stem cells
Tumor Cell Line
Mesenchymal Stromal Cells
Adipose Tissue
Tumors
2017
7 Citations (Scopus)
100 Downloads (Pure)

Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators

Bhuvanalakshmi, G., Arfuso, F., Kumar, A. P., Dharmarajan, A. & Warrier, S., 14 Aug 2017, Stem Cell Research and Therapy, 8, p. 185 15 p.

Research output: Contribution to specialist publicationArticle

Open Access
File
Wharton Jelly
Mesenchymal Stromal Cells
Cardiac Myocytes
Epigenomics
Doxorubicin
34 Citations (Scopus)
Open Access
21 Citations (Scopus)

Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiforme

Schiefer, L., Visweswaran, M., Perumal, V., Arfuso, F., Groth, D., Newsholme, P., Warrier, S. & Dharmarajan, A., 2014, In : Cancer Gene Therapy. 21, p. 297-303

Research output: Contribution to journalArticle

1 Citation (Scopus)

Role of secreted Wnt signaling inhibitors in cross-talk between trophoblast and decidual cells in co-culture

Bin Nayeem, S., Dharmarajan, A. & Keelan, J., 2014, Annual Meeting of the Society for Gynecologic Investigation, Reprod Sci. United States: SAGE Publications Ltd, Vol. 21. p. 294-5A

Research output: Chapter in Book/Conference paperConference paper

4 Citations (Scopus)

Role of Wnt signalling in early pregnancy

Nayeem, S., Arfuso, F., Dharmarajan, A. & Keelan, J., 2014, In : Reproduction, Fertility and Development. accepted 5 August 2014, published online 5 September 2014, p. doi: 10.1071/RD14079

Research output: Contribution to journalReview article

8 Citations (Scopus)

The effects of phenoxodiol on the cell cycle of prostate cancer cell lines

Mahoney, S., Arfuso, F., Millward, M. & Dharmarajan, A., 2014, In : Cancer Cell International. 14, p. 1-12

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
41 Citations (Scopus)

Wnt Antagonist, Secreted Frizzled-Related Protein 4 (sFRP4), Increases Chemotherapeutic Response of Glioma Stem-Like Cells

Warrier, S., Balu, S. K., Kumar, A., Millward, M. & Dharmarajan, A., 2014, In : Oncology Research. 21, p. 93-102

Research output: Contribution to journalArticle

2013
5 Citations (Scopus)

A synthetic herbal formulation, Dhanwantharam kashaya, delays senescence in stem cells

Warrier, S. R., Haridas, N., Balasubramanian, S., Jalisatgi, A., Bhonde, R. & Dharmarajan, A., 2013, In : Cell Proliferation. 46, 3, p. 283-290

Research output: Contribution to journalArticle

60 Citations (Scopus)

Secreted frizzled related proteins: Implications in cancers

Surana, R., Sikka, S., Cai, W., Shin, E., Warrier, S. R., Tan, H. J. G., Arfuso, F., Fox, S. A., Dharmarajan, A. & Kumar, A., 2013, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1845, 1, p. 53-65

Research output: Contribution to journalReview article

Neoplasms
Epigenomics
Frizzled Receptors
FRZB protein
Methylation
2012
9 Citations (Scopus)

Ceramide biosynthesis and metabolism in trophoblast syncytialization

Singh, A. T., Dharmarajan, A., Aye, I. & Keelan, J., 2012, In : Molecular and Cellular Endocrinology. 362, p. 48 - 59

Research output: Contribution to journalArticle

11 Citations (Scopus)

Cytotoxic effects of the novel isoflavone, phenoxodiol, on prostate cancer cell lines

Mahoney, S., Arfuso, F., Rogers, P., Hisheh, S., Brown, D., Millward, M. & Dharmarajan, A., 2012, In : Journal of Biosciences. 37, 1, p. 1-12

Research output: Contribution to journalArticle

12 Citations (Scopus)
Open Access
Inhibitor of Apoptosis Proteins
Mesothelioma
Caspases
Cisplatin
Cell Death
12 Citations (Scopus)

Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization

Singh, A. T., Dharmarajan, A., Aye, I. & Keelan, J., 2012, In : Reproductive Biomedicine Online. 24, p. 224-234

Research output: Contribution to journalArticle

2010
56 Citations (Scopus)

Secreted Frizzled-Related Protein 4. An Angiogenesis Inhibitor

Muley, A., Majumder, S., Kolluru, G. K., Parkinson, S., Viola, H., Hool, L., Arfuso, F., Ganss, R., Dharmarajan, A. & Chatterjee, S., 2010, In : The American Journal of Pathology: cellular and molecular biology of disease. 176, 3, p. 1505-1516

Research output: Contribution to journalArticle

2009
18 Citations (Scopus)

Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours

Drake, J., Sherwood, A. M., White, J., Friis, R., Zeps, N., Charles, A. & Dharmarajan, A., 2009, In : European Journal of Gynecological Oncology. 30, 2, p. 133-141

Research output: Contribution to journalArticle

Catenins
Ovarian Neoplasms
Neoplasms
Survival
Apoptosis
8 Citations (Scopus)

Expression of secreted frizzled-related protein 4 in the primate placenta

White, L., Suganthini, G., Friis, R., Dharmarajan, A. & Charles, A., 2009, In : Reproductive Biomedicine Online. 18, 1, p. 104-110

Research output: Contribution to journalArticle

Trophoblasts
Placenta
Primates
Placentation
Wnt Signaling Pathway
8 Citations (Scopus)

Function of caspase-14 in trophoblast differentiation

White, L. J., Declerq, W., Arfuso, F., Charles, A. & Dharmarajan, A., 2009, In : Reproductive Biology and Endocrinology. 7, p. 98-107

Research output: Contribution to journalArticle

Open Access
Caspase 14
Trophoblasts
Keratin-18
Intermediate Filaments
Caspases
33 Citations (Scopus)

Inhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Chopra, M., Dharmarajan, A., Meiss, G. & Schrenk, D., 2009, In : Toxicological Sciences. 111, 1, p. 49-63

Research output: Contribution to journalArticle

Ultraviolet Rays
Liver
Apoptosis
Caspases
Aryl Hydrocarbon Receptors
33 Citations (Scopus)

Proteome of synaptosome-associated proteins in spinal cord dorsal horn after peripheral nerve injury

Singh, O. V., Yaster, M., Xu, J-T., Guan, Y., Guan, X., Dharmarajan, A., Raja, S. N., Zeitlin, P. L. & Tao, Y-X., 2009, In : Proteomics. 9, 5, p. 1241-1253

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
Synaptosomes
Proteome
Spinal Injuries
Spinal Nerves
2008
19 Citations (Scopus)

Secreted frizzled related protein-4 (sFRP4) promotes epidermal differentiation and apoptosis

Maganga, R., Giles, N., Adcroft, K., Unni, A., Keeney, D., Wood, F., Fear, M. & Dharmarajan, A., 2008, In : Biochemical and Biophysical Research Communications. 377, p. 606-611

Research output: Contribution to journalArticle

Apoptosis
Skin
Keratinocytes
Maintenance
Hair Follicle
37 Citations (Scopus)

SFRP-4 abrogates Wnt-3a-induced β-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation

Constantinou, T., Baumann, F., Lacher, M. D., Saurer, S., Friis, R. & Dharmarajan, A., 2008, In : Journal of Molecular Signaling. 3, 10, p. 1-14

Research output: Contribution to journalArticle

Open Access
Catenins
Breast
Coculture Techniques
Genes
Connexin 43
12 Citations (Scopus)
Open Access
Luteolysis
Tumor Necrosis Factor-alpha
Receptors, Tumor Necrosis Factor, Type I
Corpus Luteum
Messenger RNA
2007
14 Citations (Scopus)

Caspase-14: a new player in cytotrophoblast differentiation

White, L., Dharmarajan, A. & Charles, A., 2007, In : Reproductive BioMedicine. 14, 3, p. 300-307

Research output: Contribution to journalArticle

Caspase 14
Trophoblasts
Staurosporine
Colforsin
Apoptosis

Secreted Frizzle-Related Protein (sFRP4) can abrogate pregnancy-a new dimension in its biological role

Mohan, J. J., Jha, R. K., G, P. K., Dharmarajan, A. & Laloraya, M., 2007, In : Journal of Endocinolology and Reproduction. 11, 1, p. 41-44

Research output: Contribution to journalArticle

X-linked Inhibitor of Apoptosis Protein Expression and Cisplatin Resistance in Ovarian Cancer

Mahoney, S. D., Berry, C. A., Hisheh, S. & Dharmarajan, A., 2007, In : International Journal of Integrative Biology. 1, 1, p. 4-11

Research output: Contribution to journalArticle

2006
23 Citations (Scopus)

Differential modulation of cell cycle, apoptosis and PPARy2 gene expression by PPARy agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells

Hampel, J. K. A., Brownrigg, L. M., Vignarajah, D., Croft, K., Dharmarajan, A., Bentel, J., Puddey, I. & Yeap, B., 2006, In : Prostaglandins, Leukotrienes & Essential Fatty Acids. 74, 5, p. 283-293

Research output: Contribution to journalArticle

Gene expression
Cell Cycle
Cells
Modulation
Apoptosis
42 Citations (Scopus)

Expression of sFRP-4 and β-catenin in human colorectal carcinoma

Han, Q. F., Zhao, W., Bentel, J., Shearwood, A. M., Zeps, N., Joseph, D., Iacopetta, B. & Dharmarajan, A., 2006, In : Cancer Letters. 231, p. 129-137

Research output: Contribution to journalArticle

Catenins
beta Catenin
Colorectal Neoplasms
Wnt Signaling Pathway
DNA Mismatch Repair

Injury-induced Retinal Ganglion Cell Loss in the Neonatal Rat Retina

Spalding, K. L., Cui, Q., Dharmarajan, A. & Harvey, A., 2006, Retinal Degenerative Diseases. Hollyfield, J. G., Anderson, R. E. & Lavail, M. M. (eds.). USA: Springer, p. 447-451

Research output: Chapter in Book/Conference paperChapter

24 Citations (Scopus)
Fetal Development
Glucocorticoids
Placenta
Growth
Trophoblasts
41 Citations (Scopus)

Quercetin Induces p53-Independent Apoptosis in Human Prostate Cancer Cells by Modulating Bcl-2-Related Proteins: A Possible Mediation by IGBP-3

Vijayababu, M. R., Kanagaraj, P., Arunkumar, A., Ilangovan, R., Dharmarajan, A. & Arunakaran, J., 2006, In : Oncology Research. 16, 2, p. 67-74

Research output: Contribution to journalArticle

Quercetin
Staphylococcal Protein A
Insulin-Like Growth Factor Binding Protein 3
Prostatic Neoplasms
Cells
24 Citations (Scopus)

WNT signaling in malignant mesothelioma

Fox, S. & Dharmarajan, A., 2006, In : Frontiers in Bioscience. 11, p. 2106-2112

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Asbestos
Carcinogenesis
Homeostasis
Epithelium
2005
14 Citations (Scopus)

Caspase-14 expression in the human placenta

Kam, D. W. R., Charles, A. & Dharmarajan, A., 2005, In : Reproductive Biomedicine Online. 11, 2, p. 236-243

Research output: Contribution to journalArticle

Caspase 14
Placenta
Trophoblasts
Apoptosis
First Pregnancy Trimester
19 Citations (Scopus)

Caspase-independent retinal ganglion cell death after target ablation in the neonatal rat

Spalding, K. L., Dharmarajan, A. & Harvey, A., 2005, In : European Journal of Neuroscience. 21, 1, p. 33-45

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Caspases
Cell Death
Caspase 3
Superior Colliculi
10 Citations (Scopus)

Cisplatin and TNF-α downregulate transcription of Bcl-xL in murine malignant mesothelioma cells

Fox, S. A., Kusmiaty, D., Loh, S., Dharmarajan, A. & Garlepp, M. J., 2005, In : Biochemical and Biophysical Research Communications. 337, 3, p. 983-991

Research output: Contribution to journalArticle

Transcription
Cisplatin
Down-Regulation
Gene expression
Genes

Cloning and characterization of a novel zinc finger protein (rZFP96) in the rat corpus luteum

Lareu, R., Lacher, M. D., Friis, R. R. & Dharmarajan, A., 2005, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1732, 1-3, p. 69-75

Research output: Contribution to journalArticle

Cloning
Corpus Luteum
Zinc Fingers
Zinc
Rats
1 Citation (Scopus)

Injury-induced retinal ganglion cell loss in the neonatal rat retina

Spalding, K. L., Cui, Q., Dharmarajan, A. M. & Harvey, A. R., 1 Dec 2005, In : Advances in Experimental Medicine and Biology. 572, p. 447-451 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Unusual germ cell organization in the seminiferous epithelium of a murid rodent from southern Asia, the greater bandicoot rat, Bandicota Indica

Worawittayawong, P., Leigh, C. M., Cozens, G., Peirce, E. J., Setchell, B. P., Sretarugsa, P., Dharmarajan, A. & Breed, W. G., 2005, In : International Journal of Andrology. 28, 3, p. 180-188

Research output: Contribution to journalArticle

Muridae
Seminiferous Epithelium
Murinae
Germ Cells
Rodentia
2004
9 Citations (Scopus)

Inhibition of nitric oxide synthesis potentiates apoptosis in the rabbit corpus luteum

Preutthipan, S., Chen, S. H., Tilly, J. L., Kugu, K., Lareu, R. & Dharmarajan, A., 2004, In : Reproductive Biomedicine Online. 9, 3, p. 264-270

Research output: Contribution to journalArticle

Corpus Luteum
NG-Nitroarginine Methyl Ester
Nitric Oxide
Progesterone
Apoptosis