• The University of Western Australia (M309), 35 Stirling Highway,

    6009 Perth

    Australia

  • 4311 Citations
  • 27 h-Index
19982021
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Research Output 1998 2019

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Article
2019
6 Citations (Scopus)

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

An, H., Skelt, L., Notaro, A., Highley, J. R., Fox, A. H., La Bella, V., Buchman, V. L. & Shelkovnikova, T. A., 14 Jan 2019, In : Acta Neuropathologica Communications. 7, 14 p., 7.

Research output: Contribution to journalArticle

Open Access
2018
4 Citations (Scopus)
199 Downloads (Pure)

Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins

Huang, J., Casas Garcia, G. P., Perugini, M. A., Fox, A. H., Bond, C. S. & Lee, M., 27 Apr 2018, In : The Journal of Biological Chemistry. 293, 17, p. 6593-6602 10 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Splicing
Drosophila
Dimerization
Crystal structure
Dimers
43 Citations (Scopus)

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

Yamazaki, T., Souquere, S., Chujo, T., Kobelke, S., Chong, Y. S., Fox, A. H., Bond, C. S., Nakagawa, S., Pierron, G. & Hirose, T., 21 Jun 2018, In : Molecular Cell. 701, 6, p. 1038-1053.e7

Research output: Contribution to journalArticle

Long Noncoding RNA
Clustered Regularly Interspaced Short Palindromic Repeats
RNA
RNA Isoforms
Untranslated RNA
10 Citations (Scopus)

NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

Lahaye, X., Gentili, M., Silvin, A., Conrad, C., Picard, L., Jouve, M., Zueva, E., Maurin, M., Nadalin, F., Knott, G. J., Zhao, B., Du, F., Rio, M., Amiel, J., Fox, A. H., Li, P., Etienne, L., Bond, C. S., Colleaux, L. & Manel, N., 4 Oct 2018, In : Cell. 175, 2, p. 488-501.e22

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Capsid
Chemical activation
HIV
HIV-2
5 Citations (Scopus)

Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway

Jansz, N., Nesterova, T., Keniry, A., Iminitoff, M., Hickey, P. F., Pintacuda, G., Masui, O., Kobelke, S., Geoghegan, N., Breslin, K. A., Willson, T. A., Rogers, K., Kay, G. F., Fox, A. H., Koseki, H., Brockdorff, N., Murphy, J. M. & Blewitt, M. E., 13 Nov 2018, In : Cell Reports. 25, 7, p. 1912-1923.e9

Research output: Contribution to journalArticle

Open Access
Polycomb Repressive Complex 1
X Chromosome
Chromosomes
Genes
Genome
8 Citations (Scopus)

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length

Newcombe, E. A., Ruff, K. M., Sethi, A., Ormsby, A. R., Ramdzan, Y. M., Fox, A., Purcell, A. W., Gooley, P. R., Pappu, R. V. & Hatters, D. M., 11 May 2018, In : Journal of Molecular Biology. 430, 10, p. 1442-1458 17 p.

Research output: Contribution to journalArticle

Open Access
Larva
Exons
Hydrogen
Deuterium
Huntington Disease
2017
29 Citations (Scopus)
Open Access
Long Noncoding RNA
Dissection
Protein Isoforms
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Line
16 Citations (Scopus)
124 Downloads (Pure)

Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development

Thomas-Jinu, S., Gordon, P. M., Fielding, T., Taylor, R., Smith, B. N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C. H., Bielen, H., Williams, K. L., McCann, E. P., Nicholson, G. A., Pan-Vazquez, A., Fox, A. H., Bond, C. S., Talbot, W. S., Blair, I. P., Shaw, C. E. & 1 othersHouart, C., 19 Apr 2017, In : Neuron. 94, 2, p. 322-336.e5

Research output: Contribution to journalArticle

Open Access
File
Axons
Zebrafish
Exome
Motor Neurons
Nuclear Proteins
22 Citations (Scopus)

Nuclear bodies: news insights into structure and function

Staněk, D. & Fox, A., 1 Jun 2017, In : Current Opinion in Cell Biology. 46, p. 94-101 8 p.

Research output: Contribution to journalArticle

Untranslated RNA
Ribonucleoproteins
Cell Nucleus
Innate Immunity
Carcinogenesis
8 Citations (Scopus)

Protocadherin 19 (PCDH19) interacts with paraspeckle protein NONO to co-regulate gene expression with estrogen receptor alpha (ER alpha)

Pham, D. H., Tan, C. C., Homan, C. C., Kolc, K. L., Corbett, M. A., McAninch, D., Fox, A. H., Thomas, P. Q., Kumar, R. & Gecz, J., 1 Jun 2017, In : Human Molecular Genetics. 26, 11, p. 2042-2052 11 p.

Research output: Contribution to journalArticle

Open Access
2016
4 Citations (Scopus)
93 Downloads (Pure)

A crystallographic study of human NONO (p54nrb): overcoming pathological problems with purification, data collection and noncrystallographic symmetry

Knott, G., Panjikar, S., Thorn, A., Fox, A., Conte, M. R., Lee, M. & Bond, C., Jun 2016, In : Acta Crystallographica Section D-Structural Biology. 72, 6, p. 761-769

Research output: Contribution to journalArticle

File
X-Rays
Protein Splicing
Family Relations
Crystallization
Molecular Structure
57 Citations (Scopus)

Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization

West, J. A., Mito, M., Kurosaka, S., Takumi, T., Tanegashima, C., Chujo, T., Yanaka, K., Kingston, R. E., Hirose, T., Bond, C., Fox, A. & Nakagawa, S., 26 Sep 2016, In : Journal of Cell Biology. 214, 7, p. 817-830

Research output: Contribution to journalArticle

Long Noncoding RNA
Physiological Phenomena
RNA Sequence Analysis
RNA-Binding Proteins
Corpus Luteum
53 Citations (Scopus)

The DBHS proteins SFPQ, NONO and PSPC1: A multipurpose molecular scaffold

Knott, G., Bond, C. & Fox, A., 19 May 2016, In : Nucleic Acids Research. 44, 9, p. 3989-4004

Research output: Contribution to journalArticle

Open Access
Protein Splicing
Drosophila
Nucleic Acids
Proteins
RNA Transport
17 Citations (Scopus)
Long Noncoding RNA
MicroRNAs
Skeletal Muscle
Untranslated RNA
Growth
2015
6 Citations (Scopus)

Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function

Knott, G., Lee, M., Passon, D., Fox, A. & Bond, C., Dec 2015, In : Protein Science. 24, 12, p. 2033-2043

Research output: Contribution to journalArticle

Open Access
91 Citations (Scopus)

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

Hennig, S., Kong, G., Mannen, T., Sadowska, A., Kobelke, S., Blythe, A., Knott, G. J., Swaminatha Iyer, K., Ho, D., Newcombe, E. A., Hosoki, K., Goshima, N., Kawaguchi, T., Hatters, D., Trinkle-Mulcahy, L., Hirose, T., Bond, C. & Fox, A., 17 Aug 2015, In : The Journal of Cell Biology. 210, 4, p. 529-539

Research output: Contribution to journalArticle

Open Access
Prions
Phase Transition
RNA-Binding Protein FUS
Long Noncoding RNA
RNA Recognition Motif Proteins
46 Citations (Scopus)

The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation

Lee, M., Sadowska, A., Bekere, I., Ho, D., Gully, B., Lu, Y., Swaminatha Iyer, K., Trewhella, J., Fox, A. & Bond, C., 20 Apr 2015, In : Nucleic Acids Research. 43, 7, p. 3826-3840

Research output: Contribution to journalArticle

Open Access
Nucleic Acids
Polymers
Long Noncoding RNA
Tumor Suppressor Proteins
Glutamine
2014
57 Citations (Scopus)

Effects of a Novel Long Noncoding RNA, IncUSMycN, on N-Myc Expression and Neuroblastoma Progression

Liu, P. Y., Erriquez, D., Marshall, G. M., Tee, A. E., Polly, P., Wong, M., Liu, B., Bell, J. L., Zhang, X. D., Milazzo, G., Cheung, B. B., Fox, A., Swarbrick, A., Hüttelmaier, S., Kavallaris, M., Perini, G., Mattick, J. S., Dinger, M. E. & Liu, T., Jul 2014, In : Journal of the National Cancer Institute. 106, 7, 11 p.

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Neuroblastoma
RNA
Antisense Oligonucleotides
Computational Biology
175 Citations (Scopus)

NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies

Hirose, T., Virnicchi, G., Tanigawa, A., Naganuma, T., Li, R., Kimura, H., Yokoi, T., Nakagawa, S., Bénard, M., Fox, A. & Pierron, G., Jan 2014, In : Molecular Biology of the Cell. 25, 1, p. 169-183

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Proteasome Endopeptidase Complex
Cell Death
Protein Splicing
Multiple Endocrine Neoplasia Type 1

The oestrogen receptor alpha-regulated IncRNA NEAT1 is a critical modulator of prostate cancer

Chakravarty, D., Sboner, A., Nair, S. S., Giannopoulou, E., Li, R., Henning, S., Mosquera, J. M., Pauwels, J., Park, K., Kossai, M., Macdonald, T. Y., Fontugne, J., Erho, N., Vergara, I. A., Ghadessi, M., Davicioni, E., Jenkins, R. B., Palanisamy, N., Chen, Z., Nakagawa, S. & 6 othersHirose, T., Bander, N. H., Beltran, H., Fox, A., Elemento, O. & Rubin, M. A., 2014, In : Nature Communications. 5, p. 1-16

Research output: Contribution to journalArticle

287 Citations (Scopus)

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

Chakravarty, D., Sboner, A., Nair, S. S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J. M., Pauwels, J., Park, K., Kossai, M., MacDonald, T. Y., Fontugne, J., Erho, N., Vergara, I. A., Ghadessi, M., Davicioni, E., Jenkins, R. B., Palanisamy, N., Chen, Z., Nakagawa, S. & 6 othersHirose, T., Bander, N. H., Beltran, H., Fox, A. H., Elemento, O. & Rubin, M. A., 21 Nov 2014, In : Nature Communications. 5, 5383.

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
estrogens
Estrogen Receptor alpha
Androgen Receptors
Modulators
2012
30 Citations (Scopus)

Distinct roles of DBHS family members in the circadian transcriptional feedback loop

Kowalska, E., Ripperger, J. A., Muheim, C., Maier, B., Kurihara, Y., Fox, A., Kramer, A. & Brown, S. A., 2012, In : Molecular and Cellular Biology. 32, p. 4585-4594

Research output: Contribution to journalArticle

262 Citations (Scopus)

Genome-wide analysis of long noncoding RNA stability

Clark, M. B., Johnston, R. L., Inostroza-Ponta, M., Fox, A., Fortini, E., Moscato, P., Dinger, M. E. & Mattick, J. S., 2012, In : Genome Research. 22, p. 885-898

Research output: Contribution to journalArticle

Open Access
74 Citations (Scopus)

Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation

Passon, D., Lee, M., Rackham, O., Stanley, W., Sadowska, A., Filipovska, A., Fox, A. & Bond, C., 27 Mar 2012, In : NATIONAL ACADEMY OF SCIENCES. PROCEEDINGS. 109, 13, p. 4846-4850

Research output: Contribution to journalArticle

Open Access
Drosophila
Protein Splicing
Long Noncoding RNA
Biological Phenomena
Drosophila Proteins
2011
12 Citations (Scopus)
150 Downloads (Pure)
Open Access
File
Crystallography
Crystallization
Computational Biology
Solubility
Carrier Proteins
10 Citations (Scopus)

Crystallization of a paraspeckle protein PSPC1-NONO heterodimer

Passon, D., Lee, M., Fox, A. & Bond, C., 9 Nov 2011, In : ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 67, 10, p. 1231-1234

Research output: Contribution to journalArticle

Open Access
Crystallization
Drosophila
Protein Splicing
RNA
crystallization
2010
106 Citations (Scopus)

Highly Ordered Spatial Organization of the Structural Long Noncoding NEAT1 RNAs within Paraspeckle Nuclear Bodies

Souquere, S., Beauclair, G., Harper, F., Fox, A. & Pierron, G., 2010, In : Molecular Biology of the Cell. 21, p. 4020-4027

Research output: Contribution to journalArticle

Open Access
2009
687 Citations (Scopus)

An Architectural role for a nuclear noncoding RNA : NEAT1 RNA is essential for the structure of paraspeckles

Clemson, C. M., Hutchinson, J. N., Sara, S., Ensminger, A. W., Fox, A., Chess, A. & Lawrence, J. B., 2009, In : Molecular Cell. 33, 6, p. 717-726

Research output: Contribution to journalArticle

Nuclear RNA
Untranslated RNA
RNA
RNA Interference
Proteins
6 Citations (Scopus)

Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci

Graham, J. D., Hanson, A. R., Croft, A. J., Fox, A. & Clarke, C. L., 2009, In : FASEB Journal. 23, 2, p. 546-556

Research output: Contribution to journalArticle

Nuclear Matrix
Progesterone Receptors
Progesterone
DNA
Breast
248 Citations (Scopus)

Paraspeckles: nuclear bodies built on long noncoding RNA

Bond, C. & Fox, A., 31 Aug 2009, In : The Journal of Cell Biology. 186, 5, p. 637-644

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Nuclear RNA
Ribonucleoproteins
Gene Expression Profiling
Drosophila melanogaster
2005
138 Citations (Scopus)

P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner

Fox, A., Bond, C. & Lamond, A. I., Nov 2005, In : Molecular Biology of the Cell. 16, 11, p. 5304-5315 12 p.

Research output: Contribution to journalArticle

Dichlororibofuranosylbenzimidazole
RNA Polymerase II
RNA
RNA-Binding Proteins
Mitosis
2002
751 Citations (Scopus)

Directed Proteomic Analysis of the Human Nucleolus

Andersen, J. S., Lyon, C. E., Fox, A., Leung, A. K. L., Lam, Y. W., Steen, H., Mann, M. & Lamond, A. I., 2002, In : Current Biology. 12, p. 1-11

Research output: Contribution to journalArticle

308 Citations (Scopus)

Paraspeckles: A Novel Nuclear Domain

Fox, A., Lam, Y. W., Leung, A. K. L., Lyon, C. E., Andersen, J., Mann, M. & Lamond, A. I., 2002, In : Current Biology. 12, p. 13-25

Research output: Contribution to journalArticle

cell nucleolus
Cells
Proteins
proteins
nuclear proteins
2000
47 Citations (Scopus)

A class of zinc fingers involved in protein-protein interactions

Matthews, J. M., Kowalski, K., Liew, C. K., Sharpe, B. K., Fox, A. H., Crossley, M. & Mackay, J. P., 1 Jan 2000, In : European Journal of Biochemistry. 267, 4, p. 1030-1038 9 p.

Research output: Contribution to journalArticle

Zinc Fingers
Zinc
Proteins
Histidine
Cysteine
34 Citations (Scopus)

Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions

Chu Kong Liew, K. L., Kowalski, K., Fox, A. H., Newton, A., Sharpe, B. K., Crossley, M. & Mackay, J. P., 1 Dec 2000, In : Structure. 8, 11, p. 1157-1166 10 p.

Research output: Contribution to journalArticle

Open Access
Zinc Fingers
Fingers
Proteins
Transcription Factor TFIIIA
Nucleotide Motifs
1999
92 Citations (Scopus)

hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation

Holmes, M., Turner, J., Fox, A., Chisholm, O., Crossley, M. & Chong, B., 13 Aug 1999, In : Journal of Biological Chemistry. 274, 33, p. 23491-23498 8 p.

Research output: Contribution to journalArticle

GATA Transcription Factors
Co-Repressor Proteins
Zinc Fingers
Zinc
Transcription Factors
215 Citations (Scopus)

Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers

Fox, A. H., Liew, C., Holmes, M., Kowalski, K., Mackay, J. & Crossley, M., 17 May 1999, In : EMBO Journal. 18, 10, p. 2812-2822 11 p.

Research output: Contribution to journalArticle

Zinc Fingers
Fingers
Zinc
Proteins
Aptitude
1998
52 Citations (Scopus)

Involvement of the N-finger in the self-association of GATA-1

Mackay, J. P., Kowalski, K., Fox, A. H., Czolij, R., King, G. F. & Crossley, M., 13 Nov 1998, In : Journal of Biological Chemistry. 273, 46, p. 30560-30567 8 p.

Research output: Contribution to journalArticle

Fingers
Zinc
Zinc Fingers
Proteins
Transcription Factors
73 Citations (Scopus)

Key residues characteristic of GATA N-fingers are recognized by FOG

Fox, A. H., Kowalski, K., King, G. F., Mackay, J. P. & Crossley, M., 11 Dec 1998, In : Journal of Biological Chemistry. 273, 50, p. 33595-33603 9 p.

Research output: Contribution to journalArticle

Fingers
Zinc
Zinc Fingers
Proteins
GATA Transcription Factors