Archa Fox

Dr

  • The University of Western Australia (M309), 35 Stirling Highway,

    6009 Crawley

    Australia

  • 3434 Citations
  • 23 h-Index
19982021
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Personal profile

Biography

Dr. Archa Fox is a senior lecturer in the School of Human Sciences and the School of Molecular Sciences at the University of Western Australia, and an affiliate investigator with the Harry Perkins Institute of Medical Research. Archa studied at the University of NSW and University of Sydney and was awarded her PhD in the year 2000 on a project supervised by Professor Merlin Crossley. She then moved to Dundee, UK, supported by a Wellcome Trust Fellowship to work with world-renowned scientist Professor Angus Lamond. Here she discovered a novel structure within cells that she named “paraspeckles”. In 2006 she moved back to Australia to start her own research group at the Western Australian Institute for Medical Research, now known as the Harry Perkins Institute of Medical Research. In 2015 she took up an academic position at the University of WA. Archa has an international reputation as a pioneer in the field of paraspeckle research and long noncoding RNA biology, leading to invitations to write seminal reviews and organise key symposia. She has been the recipient of the Marshall Medal of the Harry Perkins Institute in 2012, and the emerging leader award of the Australian/NZ Society of Cell and Developmental Biology in 2017.

Keywords

  • Biotechnology
  • Medicine and Pharma
  • Health
  • RNA biology
  • paraspeckles
  • long noncoding RNA
  • RNA-binding proteins
  • genome engineering
  • liquid phase separation
  • membraneless organelles
  • nuclear architecture

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 4 Similar Profiles
Long Noncoding RNA Medicine & Life Sciences
Proteins Medicine & Life Sciences
RNA Medicine & Life Sciences
Protein Splicing Medicine & Life Sciences
Zinc Fingers Medicine & Life Sciences
RNA-Binding Proteins Medicine & Life Sciences
Untranslated RNA Medicine & Life Sciences
Nuclear RNA Medicine & Life Sciences

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Projects 2008 2021

Research Output 1998 2018

Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins

Huang, J., Casas Garcia, G. P., Perugini, M. A., Fox, A. H., Bond, C. S. & Lee, M. 27 Apr 2018 In : The Journal of Biological Chemistry. 293, 17, p. 6593-6602 10 p.

Research output: Contribution to journalArticle

Protein Splicing
Drosophila
Dimerization
Crystal structure
Dimers

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

Yamazaki, T., Souquere, S., Chujo, T., Kobelke, S., Chong, Y. S., Fox, A. H., Bond, C. S., Nakagawa, S., Pierron, G. & Hirose, T. 21 Jun 2018 In : Molecular Cell. 701, 6, p. 1038-1053.e7

Research output: Contribution to journalArticle

Long Noncoding RNA
Clustered Regularly Interspaced Short Palindromic Repeats
RNA
RNA Isoforms
Untranslated RNA
3 Citations

Paraspeckles: Where Long Noncoding RNA Meets Phase Separation

Fox, A. H., Nakagawa, S., Hirose, T. & Bond, C. S. Feb 2018 In : Trends in Biochemical Sciences. 43, 2, p. 124-135 12 p.

Research output: Contribution to journalReview article

Long Noncoding RNA
Phase separation
RNA
Proteins
Gene expression

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length

Newcombe, E. A., Ruff, K. M., Sethi, A., Ormsby, A. R., Ramdzan, Y. M., Fox, A., Purcell, A. W., Gooley, P. R., Pappu, R. V. & Hatters, D. M. 11 May 2018 In : Journal of Molecular Biology. 430, 10, p. 1442-1458 17 p.

Research output: Contribution to journalArticle

Open Access
Larva
Exons
Hydrogen
Deuterium
Huntington Disease
7 Citations
Open Access
Long Noncoding RNA
Dissection
Protein Isoforms
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Line