• The University of Western Australia (M309), 35 Stirling Highway,

    6009 Perth


  • 4400 Citations
  • 27 h-Index
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Personal profile


Dr. Archa Fox is a senior lecturer in the School of Human Sciences and the School of Molecular Sciences at the University of Western Australia, and an affiliate investigator with the Harry Perkins Institute of Medical Research. Archa studied at the University of NSW and University of Sydney and was awarded her PhD in the year 2000 on a project supervised by Professor Merlin Crossley. She then moved to Dundee, UK, supported by a Wellcome Trust Fellowship to work with world-renowned scientist Professor Angus Lamond. Here she discovered a novel structure within cells that she named “paraspeckles”. In 2006 she moved back to Australia to start her own research group at the Western Australian Institute for Medical Research, now known as the Harry Perkins Institute of Medical Research. In 2015 she took up an academic position at the University of WA. Archa has an international reputation as a pioneer in the field of paraspeckle research and long noncoding RNA biology, leading to invitations to write seminal reviews and organise key symposia. She has been the recipient of the Marshall Medal of the Harry Perkins Institute in 2012, and the emerging leader award of the Australian/NZ Society of Cell and Developmental Biology in 2017.


  • Biotechnology
  • Medicine and Pharma
  • Health
  • RNA biology
  • paraspeckles
  • long noncoding RNA
  • RNA-binding proteins
  • genome engineering
  • liquid phase separation
  • membraneless organelles
  • nuclear architecture

Fingerprint Dive into the research topics where Archa Fox is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Long Noncoding RNA Medicine & Life Sciences
Proteins Medicine & Life Sciences
RNA Medicine & Life Sciences
Protein Splicing Medicine & Life Sciences
Zinc Fingers Medicine & Life Sciences
RNA-Binding Proteins Medicine & Life Sciences
Untranslated RNA Medicine & Life Sciences
Nuclear RNA Medicine & Life Sciences

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Research Output 1998 2019

8 Citations (Scopus)

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

An, H., Skelt, L., Notaro, A., Highley, J. R., Fox, A. H., La Bella, V., Buchman, V. L. & Shelkovnikova, T. A., 14 Jan 2019, In : Acta Neuropathologica Communications. 7, 14 p., 7.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The emerging roles of hnRNPK

Wang, Z., Qiu, H., He, J., Liu, L., Xue, W., Fox, A., Tickner, J. & Xu, J., 19 Sep 2019, In : Journal of Cellular Physiology.

Research output: Contribution to journalReview article

Heterogeneous-Nuclear Ribonucleoprotein K
Long Noncoding RNA
RNA-Binding Proteins
Biological Phenomena

A mitochondria–paraspeckle crosstalk

Fox, A. H., 1 Oct 2018, In : Nature Cell Biology. 20, 10, p. 1108-1109 2 p.

Research output: Contribution to journalEditorial

Long Noncoding RNA
4 Citations (Scopus)
248 Downloads (Pure)

Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins

Huang, J., Casas Garcia, G. P., Perugini, M. A., Fox, A. H., Bond, C. S. & Lee, M., 27 Apr 2018, In : The Journal of Biological Chemistry. 293, 17, p. 6593-6602 10 p.

Research output: Contribution to journalArticle

Open Access
Protein Splicing
Crystal structure
51 Citations (Scopus)

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

Yamazaki, T., Souquere, S., Chujo, T., Kobelke, S., Chong, Y. S., Fox, A. H., Bond, C. S., Nakagawa, S., Pierron, G. & Hirose, T., 21 Jun 2018, In : Molecular Cell. 701, 6, p. 1038-1053.e7

Research output: Contribution to journalArticle

Long Noncoding RNA
Clustered Regularly Interspaced Short Palindromic Repeats
RNA Isoforms
Untranslated RNA

Projects 2008 2021