• The University of Western Australia (M560), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1048 Citations
  • 17 h-Index
20012023
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Research Output 2001 2019

2019

Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profiles

Jones, A. C., Anderson, D., Galbraith, S., Fantino, E., Cardenas, D. G., Read, J. F., Serralha, M., Holt, B. J., Strickland, D. H., Sly, P. D., Bosco, A. & Holt, P. G., 19 Aug 2019, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Innate immune activation occurs in acute food protein–induced enterocolitis syndrome reactions

Mehr, S., Lee, E., Hsu, P., Anderson, D., de Jong, E., Bosco, A. & Campbell, D. E., 4 May 2019, In : Journal of Allergy and Clinical Immunology. 5 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis

Jones, A. C., Anderson, D., Galbraith, S., Fantino, E., Cardenas, D. G., Read, J. F., Serralha, M., Holt, B. J., Strickland, D. H., Sly, P. D., Bosco, A. & Holt, P. G., 15 Jun 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1537-1549 13 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Fc Receptors
Blood Cells
Asthma
Dendritic Cells
Basophils
2 Citations (Scopus)
223 Downloads (Pure)

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

Zemek, R., de Jong, E., Chin, M., Schuster, I., Fear, V., Casey, T., Forbes, C., Dart, S., Leslie, C., Zaitouny, A., Small, M., Boon, L., Forrest, A. R. R., O Muiri, D., Degli-Esposti, M., Millward, M., Nowak, A., Lassmann, T., Bosco, A., Lake, R. & 1 othersLesterhuis, W., 17 Jul 2019, In : Science Translational Medicine. 11, 501, 14 p., eaav7816.

Research output: Contribution to journalArticle

Open Access
File
STAT1 Transcription Factor
Tumor Microenvironment
Neoplasms
Toll-Like Receptor 3
Transcriptome
1 Citation (Scopus)

Upper airway cell transcriptomics identify a major new immunological phenotype with strong clinical correlates in young children with acute wheezing

Khoo, S. K., Read, J., Franks, K., Zhang, G., Bizzintino, J., Coleman, L., McCrae, C., Öberg, L., Troy, N. M., Prastanti, F., Everard, J., Oo, S., Borland, M. L., Maciewicz, R. A., Le Souëf, P. N., Laing, I. A. & Bosco, A., 1 Jan 2019, In : Journal of Immunology. 202, 6, p. 1845-1858 14 p.

Research output: Contribution to journalArticle

Respiratory Sounds
Phenotype
Asthma
Up-Regulation
Rhinovirus

Very Early Identification and Intervention for Infants at Risk of Neurodevelopmental Disorders: A Transdiagnostic Approach

Finlay-Jones, A., Varcin, K., Leonard, H., Bosco, A., Alvares, G. & Downs, J., 4 Jun 2019, In : Child Development Perspectives. 13, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

infant
Behavioral Symptoms
Systems Biology
Attention Deficit Disorder with Hyperactivity
Neurosciences
2018

Asthma and unified airways disease through epithelial cells

De Jong, E., Ling, K., Nichol, K., Anderson, D., Wark, P., Knight, D., Bosco, A., Stick, S. & Kicic, A., Aug 2018, In : Allergy. 73, p. 20-20 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Atopy-dependent and independent immune responses in the heightened severity of atopics to respiratory viral infections: Rat model studies

Lauzon-Joset, J. F., Jones, A. C., Mincham, K. T., Thomas, J. A., Rosenthal, L. A., Bosco, A., Holt, P. G. & Strickland, D. H., 13 Aug 2018, In : Frontiers in Immunology. 9, AUG, 1805.

Research output: Contribution to journalArticle

Open Access
Virus Diseases
Respiratory Tract Infections
Inbred BN Rats
Interferon Type I
Antiviral Agents
2 Citations (Scopus)

CD8(+)XCR1(neg) dendritic cells express high levels of toll-like receptor 5 and a unique complement of endocytic receptors

Wylie, B., Read, J., Buzzai, A., Troy, N., Syn, G., Stone, S., Foley, B., Bosco, A., Cruickshank, M. N. & Waithman, J., May 2018, In : European Journal of Immunology. 48, p. 157-158 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

1 Citation (Scopus)

CD8+XCR1neg dendritic cells express high levels of toll-like receptor 5 and a unique complement of endocytic receptors

Wylie, B., Read, J., Buzzai, A. C., Wagner, T., Troy, N., Syn, G., Stone, S. R., Foley, B., Bosco, A., Cruickshank, M. N. & Waithman, J., 16 Jan 2018, In : Frontiers in Immunology. 9, 2990.

Research output: Contribution to journalArticle

Open Access
Toll-Like Receptor 5
Complement Receptors
Dendritic Cells
C Chemokines
Immunologic Monitoring
1 Citation (Scopus)

Dissecting asthma transcriptomics: Does site matter?

De Jong, E. & Bosco, A., 1 Feb 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 2, p. 144-146 3 p.

Research output: Contribution to journalEditorial

Infants hospitalised for severe viral bronchiolitis manifest dysregulated interferon (particularly types 1 & 3) responses

Jones, A. C., Anderson, D., Read, J. F., Serralha, M., Holt, B. J., Galbraith, S., Fantino, E., Varghese, J., Cardenas, G. D., Sly, P. D., Strickland, D. S., Bosco, A. & Holt, P. G., Aug 2018, In : Allergy. 73, p. 12-12 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2 Citations (Scopus)

Insights into respiratory disease through bioinformatics

Hurgobin, B., de Jong, E. & Bosco, A., Dec 2018, In : Respirology. 23, 12, p. 1117-1126

Research output: Contribution to journalReview article

Open Access
Computational Biology
Lung Diseases
Lung Neoplasms
Drug Repositioning
Precision Medicine
7 Citations (Scopus)

Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

Jones, A. C., Troy, N. M., White, E., Hollams, E. M., Gout, A. M., Ling, K. M., Kicic, A., Stick, S. M., Sly, P. D., Holt, P. G., Hall, G. L. & Bosco, A., 1 Dec 2018, In : Scientific Reports. 8, 1, 1511.

Research output: Contribution to journalArticle

Open Access
Gene Regulatory Networks
Sputum
Asthma
Pyroglyphidae
Interleukin-13
2017

Activation of inflammatory cells during asthma exacerbations is initiated prior to their migration to the lung

Jones, A. C., Bizzintino, J., Khoo, S., Rueter, K., Laing, I. A., Goldblatt, J., Le Soeuf, P. N., Sly, P. D., Strickland, D. H., Bosco, A. & Holt, P. G., Aug 2017, In : Allergy. 72, p. 50-51 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

9 Citations (Scopus)

A genome-by-environment interaction classifier for precision medicine: Personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations

Gardeux, V., Berghout, J., Achour, I., Schissler, A. G., Li, Q., Kenost, C., Li, J., Shang, Y., Bosco, A., Saner, D., Halonen, M. J., Jackson, D. J., Li, H., Martinez, F. D. & Lussier, Y. A., 1 Nov 2017, In : Journal of the American Medical Informatics Association. 24, 6, p. 1116-1126 11 p.

Research output: Contribution to journalArticle

Open Access
Rhinovirus
Precision Medicine
Transcriptome
Asthma
Genome
10 Citations (Scopus)

CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis

Tarique, A. A., Sly, P. D., Holt, P. G., Bosco, A., Ware, R. S., Logan, J., Bell, S. C., Wainwright, C. E. & Fantino, E., 1 Jul 2017, In : Journal of Cystic Fibrosis. 16, 4, p. 475-482 8 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Macrophages
Membranes
Lung Diseases
Phenotype
2 Citations (Scopus)

Critical role of plasmacytoid dendritic cells in regulating gene expression and innate immune responses to human rhinovirus-16

Xi, Y., Troy, N. M., Anderson, D., Pena, O. M., Lynch, J. P., Phipps, S., Bosco, A. & Upham, J. W., 25 Oct 2017, In : Frontiers in Immunology. 8, OCT, 1351.

Research output: Contribution to journalArticle

Open Access
Rhinovirus
Innate Immunity
Dendritic Cells
Interferons
Gene Expression
50 Citations (Scopus)
496 Downloads (Pure)
Open Access
File
Tumor Biomarkers
Biomarkers
Mathematics
Drug Industry
Therapeutics
27 Citations (Scopus)

Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers

DeVries, A., Wlasiuk, G., Miller, S., Bosco, A., Stern, D. A., Lohman, I. C., Rothers, J., Jones, A. C., Nicodemus-Johnson, J., Vasquez, M. M., Curtin, J. A., Simpson, A., Custovic, A., Jackson, D. J., Gern, J. E., Lemanske, R. F., Guerra, S., Wright, A. L., Ober, C., Halonen, M. & 1 othersVercelli, D., 1 Aug 2017, In : Journal of Allergy and Clinical Immunology. 140, 2, p. 534-542 9 p.

Research output: Contribution to journalArticle

Methylation
Asthma
Mothers
Parturition
Epigenomics
4 Citations (Scopus)

Protection against maternal infection-associated fetal growth restriction: proof-of-concept with a microbial-derived immunomodulator

Scott, N. M., Lauzon-Joset, J. F., Jones, A. P., Mincham, K., Troy, N., Leffler, J., Serralha, M., Prescott, S. L., Robertson, S. A., Pasquali, C., Bosco, A., Holt, P. G. & Strickland, D. H., 2017, In : Mucosal Immunology. 10, 3, p. 789 801 p.

Research output: Contribution to journalArticle

Immunologic Factors
Fetal Development
Mothers
Infection
Pregnancy
5 Citations (Scopus)

Using network analysis to understand severe asthma phenotypes

Jones, A. C. & Bosco, A., 1 Jun 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 11, p. 1409-1411 3 p.

Research output: Contribution to journalEditorial

2016

Benign versus pathologic Th2-immunity in atopic children

Holt, P. G., Strickland, D., Bosco, A., Belgrave, D., Hales, B. J., Simpson, A., Hollams, E., Holt, B., Kusel, M., Ahlstedt, S., Sly, P. D. & Custovic, A., 2016, Allergies: Current Challenges and Solutions: Proceedings of the 30th Symposium of the Collegium Internationale Allergologicum. Maurer, M. & Behrendt, H. (eds.). Italy: Pacini Editore Medicina, p. 155-159 5 p.

Research output: Chapter in Book/Conference paperConference paper

17 Citations (Scopus)
Open Access
Gene Regulatory Networks
Allergens
Pyroglyphidae
Asthma
T-Lymphocytes
26 Citations (Scopus)
165 Downloads (Pure)

Distinguishing benign from pathologic TH2 immunity in atopic children

Holt, P., Strickland, D., Bosco, A., Belgrave, D., Hales, B., Simpson, A., Hollams, E., Holt, B., Kusel, M., Ahlstedt, S., Sly, P. D. & Custovic, A., Feb 2016, In : Journal of Allergy and Clinical Immunology. 137, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

Open Access
File
Immunity
Immunoglobulin E
Immunoglobulin G
Allergens
Asthma
6 Citations (Scopus)
169 Downloads (Pure)

Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

Looi, K., Troy, N. M., Garratt, L. W., Iosifidis, T., Bosco, A., Buckley, A. G., Ling, K-M. M., Martinovich, K. M., Kicic-Starcevich, L., Shaw, N. C., Sutanto, E. N., Zosky, G. R., Rigby, P. J., Larcombe, A. N., Knight, D. A., Kicic, A. & Stick, S. M., 11 Oct 2016, In : Experimental Lung Research. 42, 7, p. 380-395 16 p.

Research output: Contribution to journalArticle

Open Access
File
Tight Junction Proteins
Rhinovirus
Polymerase chain reaction
Zonula Occludens-1 Protein
Claudin-1
6 Citations (Scopus)
Vitamin D Deficiency
Pyroglyphidae
Pneumonia
Genes
Smooth Muscle
26 Citations (Scopus)

Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection

Bosco, A., Wiehler, S. & Proud, D., 2016, In : BMC Genomics. 17, 12 p., 76.

Research output: Contribution to journalArticle

Open Access
Interferon Regulatory Factor-7
Rhinovirus
Epithelial Cells
Infection
Genes
12 Citations (Scopus)

Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjects

Eguíluz-Gracia, I., Bosco, A., Dollner, R., Melum, G. R., Lexberg, M. H., Jones, A. C., Dheyauldeen, S. A., Holt, P. G., Bækkevold, E. S. & Jahnsen, F. L., 2016, In : Journal of Allergy and Clinical Immunology. 137, 6, p. 1872-1881.e12 22 p.

Research output: Contribution to journalArticle

Phagocytes
Monocytes
Eosinophils
Chemokines
Allergens
11 Citations (Scopus)

Respiratory viral infections and host responses; insights from genomics

Troy, N. M. & Bosco, A., 21 Nov 2016, In : Respiratory Research. 17, 1, 156.

Research output: Contribution to journalReview article

Open Access
Virus Diseases
Genomics
Respiratory Tract Infections
Respiratory Syncytial Virus Infections
Rhinovirus
7 Citations (Scopus)

Rhinovirus-induced asthma exacerbations and risk populations

Coleman, L., Laing, I. A. & Bosco, A., 2016, In : Current Opinion in Allergy and Clinical Immunology. 16, 2, p. 179-185 7 p.

Research output: Contribution to journalReview article

Rhinovirus
Asthma
Population
Viruses
Environmental Exposure
2015
18 Citations (Scopus)

Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

Lesterhuis, W., Rinaldi, C., Jones, A., Rozali, E., Dick, I., Khong, A., Boon, L., Robinson, B., Nowak, A., Bosco, A. & Lake, R., 21 Jul 2015, In : Scientific Reports. 5, p. 1-11 11 p., 12298 .

Research output: Contribution to journalArticle

Open Access
Drug Combinations
Immunotherapy
Drug Repositioning
Neoplasms
Chromosome Mapping
26 Citations (Scopus)

The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function

Foong, R., Bosco, A., Jones, A., Gout, A., Gorman, S., Hart, P. & Zosky, G. R., 1 Nov 2015, In : American Journal of Respiratory Cell and Molecular Biology. 53, 5, p. 664-675 12 p.

Research output: Contribution to journalArticle

Open Access
Vitamin D Deficiency
Vitamin D
Smooth Muscle
Muscle
Lung
14 Citations (Scopus)

Towards a PBMC "virogram assay" for precision medicine: concordance between ex vivo and in vivo viral infection transcriptomes

Gardeux, V., Bosco, A., Li, J., Halonen, M. J., Jackson, D., Martinez, F. D. & Lussier, Y. A., 2015, In : Journal of Biomedical Informatics. 55, p. 94-103

Research output: Contribution to journalArticle

Open Access
Precision Medicine
Virus Diseases
Transcriptome
Rhinovirus
Blood Cells
2014
5 Citations (Scopus)

Comment on "Drug discovery: Turning the titanic"

Lesterhuis, W., Bosco, A. & Lake, R., 2014, In : Science Translational Medicine. 6, 229, p. 229le2

Research output: Contribution to journalLetter

Drug Discovery
Research
9 Citations (Scopus)

Genomic Responses during Acute Human Anaphylaxis Are Characterized by Upregulation of Innate Inflammatory Gene Networks

Stone, S., Bosco, A., Jones, A., Cotterell, C., Van Eeden, P., Arendts, G., Fatovich, D. & Brown, S., 1 Jul 2014, In : PLoS One. 9, 7, 10 p., e101409.

Research output: Contribution to journalArticle

Open Access
anaphylaxis
Gene Regulatory Networks
Anaphylaxis
Up-Regulation
Genes
9 Citations (Scopus)

Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection

Agdestein, A., Jones, A., Flatberg, A., Johansen, T. B., Heffernan, I. A., Djønne, B., Bosco, A. & Olsen, I., 2014, In : BMC Genomics. 15, p. 14

Research output: Contribution to journalArticle

Open Access
2013
23 Citations (Scopus)

In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice

Ramsey, K., Bosco, A., Mckenna, K., Carter, K., Elliot, J. G., Berry, L. J., Sly, P. D., Larcombe, A. & Zosky, G., 2013, In : Environmental Health Perspectives. 121, p. 244-250

Research output: Contribution to journalArticle

2012
15 Citations (Scopus)

A genomics-based approach to assessment of vaccine safety and immunogenicity in children

White, O., Mckenna, K., Bosco, A., Van Den Biggelaar, A., Richmond, P. & Holt, P., 2012, In : Vaccine. 30, 10, p. 1865-1874

Research output: Contribution to journalArticle

11 Citations (Scopus)

Airway Epithelial Cells Condition Dendritic Cells to Express Multiple Immune Surveillance Genes

Rate, A., Bosco, A., Mckenna, K., Holt, P. & Upham, J. W., 11 Sep 2012, In : PLoS One. 7, 9, p. e44941.1-10

Research output: Contribution to journalArticle

Open Access
dendritic cells
Dendritic Cells
epithelial cells
Genes
Epithelial Cells
40 Citations (Scopus)

Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo

Bosco, A., Ehteshami, S., Panyala, S. & Martinez, F. D., 2012, In : Journal of Allergy and Clinical Immunology. 129, 1, p. 88

Research output: Contribution to journalArticle

22 Citations (Scopus)

T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy

Martino, D., Bosco, A., Mckenna, K., Hollams, E., Mok, D., Holt, P. & Prescott, S., 2012, In : Allergy. 67, 2, p. 191-200

Research output: Contribution to journalArticle

2011
16 Citations (Scopus)

Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell tolerance

Van Den Biggelaar, A. H. J., Pomat, W., Bosco, A., Phuanukoonnon, S., Devitt, C. J., Nadal-Sims, M. A., Siba, P. M., Richmond, P., Lehmann, D. & Holt, P., 2011, In : Vaccine. 29, 33, p. 5414-5420

Research output: Contribution to journalArticle

Open Access
2010
102 Citations (Scopus)

Toward improved prediction of risk for atopy and asthma among preschoolers: A prospective cohort study

Holt, P., Rowe, J., Kusel, M., Parsons, F., Hollams, E. M., Bosco, A., Mckenna, K., Subrata, L., De Klerk, N., Serralha, M., Holt, B. J., Zhang, G., Loh, R., Ahlstedt, S. & Sly, P., 2010, In : Journal of Allergy and Clinical Immunology. 125, 3, p. 653-659.e7

Research output: Contribution to journalArticle

2009
70 Citations (Scopus)
Dendritic Cells
Epithelial Cells
Phenotype
Cell Differentiation
Interleukin-6
52 Citations (Scopus)

Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response

Yerkovich, S. T., Roponen, M., Smith, M., Mckenna, K., Bosco, A., Subrata, L. S., Mamessier, E., Wikstrom, M., Le Souef, P., Sly, P., Holt, P. & Upham, J., 2009, In : Journal of Allergy and Clinical Immunology. 123, 1, p. 209-216.e4

Research output: Contribution to journalArticle

Thrombomodulin
Allergens
Dendritic Cells
Blood Cells
Antigens
25 Citations (Scopus)

A network modeling approach to analysis of the Th2 memory responses underlying human atopic disease

Bosco, A., Mckenna, K., Firth, M., Sly, P. & Holt, P., 2009, In : Journal of Immunology. 182, 10, p. 6011-6021

Research output: Contribution to journalArticle

Gene Regulatory Networks
Genes
Regulatory T-Lymphocytes
Gene Expression
Microarray Analysis
154 Citations (Scopus)

Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children

Subrata, L. S., Bizzintino, J. A., Mamessier, E., Bosco, A., Mckenna, K., Wikstrom, M., Goldblatt, J., Sly, P., Hales, B., Thomas, W., Laing, I., Le Souef, P. & Holt, P., 2009, In : Journal of Immunology. 183, 4, p. 2793-2800

Research output: Contribution to journalArticle

Interleukin-13
Virus Diseases
Allergens
Antiviral Agents
Monocytes