Anthony Bosco

Dr

  • The University of Western Australia (M560), 35 Stirling Highway,

    6009 Crawley

    Australia

  • 849 Citations
  • 15 h-Index
20012022
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Research Output 2001 2018

2018
2 Citations

Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

Jones, A. C., Troy, N. M., White, E., Hollams, E. M., Gout, A. M., Ling, K. M., Kicic, A., Stick, S. M., Sly, P. D., Holt, P. G., Hall, G. L. & Bosco, A. 1 Dec 2018 In : Scientific Reports. 8, 1, 1511

Research output: Contribution to journalArticle

Open Access
Gene Regulatory Networks
Sputum
Asthma
Interleukin-13
Mucociliary Clearance
2017

Activation of inflammatory cells during asthma exacerbations is initiated prior to their migration to the lung

Jones, A. C., Bizzintino, J., Khoo, S., Rueter, K., Laing, I. A., Goldblatt, J., Le Soeuf, P. N., Sly, P. D., Strickland, D. H., Bosco, A. & Holt, P. G. Aug 2017 In : Allergy. 72, p. 50-51 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

A genome-by-environment interaction classifier for precision medicine: Personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations

Gardeux, V., Berghout, J., Achour, I., Schissler, A. G., Li, Q., Kenost, C., Li, J., Shang, Y., Bosco, A., Saner, D., Halonen, M. J., Jackson, D. J., Li, H., Martinez, F. D. & Lussier, Y. A. 1 Nov 2017 In : Journal of the American Medical Informatics Association. 24, 6, p. 1116-1126 11 p.

Research output: Contribution to journalArticle

Rhinovirus
Precision Medicine
Transcriptome
Asthma
Genome
3 Citations

CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis

Tarique, A. A., Sly, P. D., Holt, P. G., Bosco, A., Ware, R. S., Logan, J., Bell, S. C., Wainwright, C. E. & Fantino, E. 1 Jul 2017 In : Journal of Cystic Fibrosis. 16, 4, p. 475-482 8 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Macrophages
Membranes
Lung Diseases
Phenotype
1 Citations

Critical role of plasmacytoid dendritic cells in regulating gene expression and innate immune responses to human rhinovirus-16

Xi, Y., Troy, N. M., Anderson, D., Pena, O. M., Lynch, J. P., Phipps, S., Bosco, A. & Upham, J. W. 25 Oct 2017 In : Frontiers in Immunology. 8, OCT, 1351

Research output: Contribution to journalArticle

Open Access
Rhinovirus
Innate Immunity
Dendritic Cells
Interleukin-27
Gene Expression
21 Citations
Open Access
File
Tumor Biomarkers
Biomarkers
Mathematics
Drug Industry
Therapeutics
14 Citations

Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers

DeVries, A. , Wlasiuk, G. , Miller, S. , Bosco, A. , Stern, D. A. , Lohman, I. C. , Rothers, J. , Jones, A. C. , Nicodemus-Johnson, J. , Vasquez, M. M. , Curtin, J. A. , Simpson, A. , Custovic, A. , Jackson, D. J. , Gern, J. E. , Lemanske, R. F. , Guerra, S. , Wright, A. L. , Ober, C. , Halonen, M. & 1 others Vercelli, D. 1 Aug 2017 In : Journal of Allergy and Clinical Immunology. 140, 2, p. 534-542 9 p.

Research output: Contribution to journalArticle

Methylation
Asthma
Mothers
Parturition
Epigenomics
1 Citations

Protection against maternal infection-associated fetal growth restriction: proof-of-concept with a microbial-derived immunomodulator

Scott, N. M., Lauzon-Joset, J. F., Jones, A. P., Mincham, K., Troy, N., Leffler, J., Serralha, M., Prescott, S. L., Robertson, S. A., Pasquali, C., Bosco, A., Holt, P. G. & Strickland, D. H. 2017 In : Mucosal Immunology. 10, 3, p. 789 801 p.

Research output: Contribution to journalArticle

Immunologic Factors
Fetal Development
Mothers
Infection
Pregnancy
2 Citations

Using network analysis to understand severe asthma phenotypes

Jones, A. C. & Bosco, A. 1 Jun 2017 In : American Journal of Respiratory and Critical Care Medicine. 195, 11, p. 1409-1411 3 p.

Research output: Contribution to journalEditorial

2016

Benign versus pathologic Th2-immunity in atopic children

Holt, P. G., Strickland, D., Bosco, A., Belgrave, D., Hales, B. J., Simpson, A., Hollams, E., Holt, B., Kusel, M., Ahlstedt, S., Sly, P. D. & Custovic, A. 2016 Allergies: Current Challenges and Solutions: Proceedings of the 30th Symposium of the Collegium Internationale Allergologicum. Maurer, M. & Behrendt, H. (eds.). Italy: Pacini Editore Medicina, p. 155-159 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference paper

11 Citations
Open Access
Gene Regulatory Networks
Allergens
Pyroglyphidae
Asthma
T-Lymphocytes
15 Citations

Distinguishing benign from pathologic TH2 immunity in atopic children

Holt, P., Strickland, D., Bosco, A., Belgrave, D., Hales, B., Simpson, A., Hollams, E., Holt, B., Kusel, M., Ahlstedt, S., Sly, P. D. & Custovic, A. Feb 2016 In : Journal of Allergy and Clinical Immunology. 137, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

Open Access
File
Immunity
Immunoglobulin E
Immunoglobulin G
Allergens
Asthma
2 Citations

Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

Looi, K., Troy, N. M., Garratt, L. W., Iosifidis, T., Bosco, A., Buckley, A. G., Ling, K-M. M., Martinovich, K. M., Kicic-Starcevich, L., Shaw, N. C., Sutanto, E. N., Zosky, G. R., Rigby, P. J., Larcombe, A. N., Knight, D. A., Kicic, A. & Stick, S. M. 11 Oct 2016 In : Experimental Lung Research. 42, 7, p. 380-395 16 p.

Research output: Contribution to journalArticle

Open Access
File
Tight Junction Proteins
Rhinovirus
Polymerase chain reaction
Zonula Occludens-1 Protein
Claudin-1
6 Citations
Vitamin D Deficiency
Pyroglyphidae
Pneumonia
Genes
Smooth Muscle
14 Citations

Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection

Bosco, A., Wiehler, S. & Proud, D. 2016 In : BMC Genomics. 17, 12 p., 76

Research output: Contribution to journalArticle

Open Access
Interferon Regulatory Factor-7
Rhinovirus
Epithelial Cells
Infection
Genes
5 Citations

Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjects

Eguíluz-Gracia, I., Bosco, A., Dollner, R., Melum, G. R., Lexberg, M. H., Jones, A. C., Dheyauldeen, S. A., Holt, P. G., Bækkevold, E. S. & Jahnsen, F. L. 2016 In : Journal of Allergy and Clinical Immunology. 137, 6, p. 1872-1881.e12 22 p.

Research output: Contribution to journalArticle

Phagocytes
Monocytes
Eosinophils
Chemokines
Allergens
8 Citations

Respiratory viral infections and host responses; insights from genomics

Troy, N. M. & Bosco, A. 21 Nov 2016 In : Respiratory Research. 17, 1, 156

Research output: Contribution to journalReview article

Open Access
Virus Diseases
Genomics
Respiratory Tract Infections
Respiratory Syncytial Virus Infections
Rhinovirus
3 Citations

Rhinovirus-induced asthma exacerbations and risk populations

Coleman, L., Laing, I. A. & Bosco, A. 2016 In : Current Opinion in Allergy and Clinical Immunology. 16, 2, p. 179-185 7 p.

Research output: Contribution to journalReview article

Rhinovirus
Asthma
Population
Viruses
Environmental Exposure
2015
7 Citations

Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

Lesterhuis, W., Rinaldi, C., Jones, A., Rozali, E., Dick, I., Khong, A., Boon, L., Robinson, B., Nowak, A., Bosco, A. & Lake, R. 21 Jul 2015 In : Scientific Reports. 5, p. 1-11 11 p., 12298

Research output: Contribution to journalArticle

Open Access
Drug Combinations
Immunotherapy
Drug Repositioning
Neoplasms
Chromosome Mapping
20 Citations
Open Access
Vitamin D Deficiency
Vitamin D
Smooth Muscle
Muscle
Lung
10 Citations

Towards a PBMC "virogram assay" for precision medicine: concordance between ex vivo and in vivo viral infection transcriptomes

Gardeux, V., Bosco, A., Li, J., Halonen, M. J., Jackson, D., Martinez, F. D. & Lussier, Y. A. 2015 In : Journal of Biomedical Informatics. 55, p. 94-103

Research output: Contribution to journalArticle

Open Access
Precision Medicine
Virus Diseases
Transcriptome
Rhinovirus
Blood Cells
2014
5 Citations

Comment on "Drug discovery: Turning the titanic"

Lesterhuis, W., Bosco, A. & Lake, R. 2014 In : SCIENCE TRANSLATIONAL MEDICINE. 6, 229, p. 229le2

Research output: Contribution to journalLetter

Drug Discovery
Research
7 Citations

Genomic Responses during Acute Human Anaphylaxis Are Characterized by Upregulation of Innate Inflammatory Gene Networks

Stone, S., Bosco, A., Jones, A., Cotterell, C., Van Eeden, P., Arendts, G., Fatovich, D. & Brown, S. 1 Jul 2014 In : PLoS One. 9, 7, 10 p., e101409

Research output: Contribution to journalArticle

Open Access
anaphylaxis
Gene Regulatory Networks
Anaphylaxis
Up-Regulation
Genes
8 Citations

Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection

Agdestein, A., Jones, A., Flatberg, A., Johansen, T. B., Heffernan, I. A., Djønne, B., Bosco, A. & Olsen, I. 2014 In : BMC Genomics. 15, p. 14

Research output: Contribution to journalArticle

Open Access
2013
18 Citations

In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice

Ramsey, K., Bosco, A., Mckenna, K., Carter, K., Elliot, J. G., Berry, L. J., Sly, P. D., Larcombe, A. & Zosky, G. 2013 In : Environmental Health Perspectives. 121, p. 244-250

Research output: Contribution to journalArticle

2012
14 Citations

A genomics-based approach to assessment of vaccine safety and immunogenicity in children

White, O., Mckenna, K., Bosco, A., Van Den Biggelaar, A., Richmond, P. & Holt, P. 2012 In : Vaccine. 30, 10, p. 1865-1874

Research output: Contribution to journalArticle

9 Citations

Airway Epithelial Cells Condition Dendritic Cells to Express Multiple Immune Surveillance Genes

Rate, A., Bosco, A., Mckenna, K., Holt, P. & Upham, J. W. 11 Sep 2012 In : PLoS One. 7, 9, p. e44941.1-10

Research output: Contribution to journalArticle

Open Access
dendritic cells
Dendritic Cells
epithelial cells
Genes
Epithelial Cells
31 Citations

Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo

Bosco, A., Ehteshami, S., Panyala, S. & Martinez, F. D. 2012 In : Journal of Allergy and Clinical Immunology. 129, 1, p. 88

Research output: Contribution to journalArticle

20 Citations

T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy

Martino, D., Bosco, A., Mckenna, K., Hollams, E., Mok, D., Holt, P. & Prescott, S. 2012 In : Allergy. 67, 2, p. 191-200

Research output: Contribution to journalArticle

2011
15 Citations

Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell tolerance

Van Den Biggelaar, A. H. J., Pomat, W., Bosco, A., Phuanukoonnon, S., Devitt, C. J., Nadal-Sims, M. A., Siba, P. M., Richmond, P., Lehmann, D. & Holt, P. 2011 In : Vaccine. 29, 33, p. 5414-5420

Research output: Contribution to journalArticle

Open Access
2010
94 Citations

Toward improved prediction of risk for atopy and asthma among preschoolers: A prospective cohort study

Holt, P., Rowe, J., Kusel, M., Parsons, F., Hollams, E. M., Bosco, A., Mckenna, K., Subrata, L., De Klerk, N., Serralha, M., Holt, B. J., Zhang, G., Loh, R., Ahlstedt, S. & Sly, P. 2010 In : Journal of Allergy and Clinical Immunology. 125, 3, p. 653-659.e7

Research output: Contribution to journalArticle

2009
67 Citations
Dendritic Cells
Epithelial Cells
Phenotype
Cell Differentiation
Interleukin-6
52 Citations

Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response

Yerkovich, S. T., Roponen, M., Smith, M., Mckenna, K., Bosco, A., Subrata, L. S., Mamessier, E., Wikstrom, M., Le Souef, P., Sly, P., Holt, P. & Upham, J. 2009 In : Journal of Allergy and Clinical Immunology. 123, 1, p. 209-216.e4

Research output: Contribution to journalArticle

Thrombomodulin
Allergens
Dendritic Cells
Blood Cells
Antigens
25 Citations

A network modeling approach to analysis of the Th2 memory responses underlying human atopic disease

Bosco, A., Mckenna, K., Firth, M., Sly, P. & Holt, P. 2009 In : Journal of Immunology. 182, 10, p. 6011-6021

Research output: Contribution to journalArticle

Gene Regulatory Networks
Genes
Regulatory T-Lymphocytes
Gene Expression
Microarray Analysis
142 Citations

Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children

Subrata, L. S., Bizzintino, J. A., Mamessier, E., Bosco, A., Mckenna, K., Wikstrom, M., Goldblatt, J., Sly, P., Hales, B., Thomas, W., Laing, I., Le Souef, P. & Holt, P. 2009 In : Journal of Immunology. 183, 4, p. 2793-2800

Research output: Contribution to journalArticle

Interleukin-13
Virus Diseases
Allergens
Antiviral Agents
Monocytes
45 Citations
Interleukin-5
Respiratory Tract Infections
Interleukin-10
Parturition
T-Lymphocytes
15 Citations

Pathogenic mechanisms of allergic inflammation : atopic asthma as a paradigm

Holt, P., Strickland, D., Bosco, A. & Jahnsen, F. L. 2009 Advances in Immunology. Alt, F. W. (ed.). Chatswood, NSW: Elsevier, Vol. 104, p. 51-113

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2008
1 Citations

Genome-wide expression profiling of T-cells in childhood wheeze

Bosco, A. & Holt, P. 2008 In : European Respiratory Journal. 32, 5, p. 1138-1140

Research output: Contribution to journalReview article

2007
File
Allergens
T-Lymphocytes
Genes
Dermatophagoides Antigens
Cytokines
2004
32 Citations

Isoforms of the Major Peanut Allergen Ara h 2: IgE Binding in Children with Peanut Allergy

Hales, B. J., Bosco, A., Mills, K. L., Hazell, L. A., Loh, R., Holt, P. & Thomas, W. 2004 In : International Archives of Allergy and Immunology. 135, 2, p. 101-107

Research output: Contribution to journalArticle

Peanut Hypersensitivity
Immunoglobulin E
Protein Isoforms
Clone Cells
Arachis hypogaea Ara h 2 allergen
2001
104 Citations

Regulation of dendritic cell recruitment into resting and inflamed airway epithelium: use of alternative chemokine receptors as a function of inducing stimulus

Stumbles, P., Strickland, D. H., Pimm, C. L., Proksch, S. F., Marsh, A. M., Mcwilliam, A. S., Bosco, A., Tobagus, I., Thomas, J. A., Napoli, S., Proudfoot, A. E. I., Wells, T. N. C. & Holt, P. 2001 In : Journal of Immunology. 167, p. 228-234

Research output: Contribution to journalArticle

Chemokine Receptors
Dendritic Cells
Epithelium
Aerosols
Ligands