Anita Chua

Dr, BSc PhD W.Aust.

  • The University of Western Australia (M582), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1022 Citations
  • 18 h-Index
19962020

Research output per year

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Research Output

2020

Decreased Physical Working Capacity in Adolescents With Nonalcoholic Fatty Liver Disease Associates With Reduced Iron Availability

Mitchell, T., McKinnon, E., Ayonrinde, O., Adams, L. A., Trinder, D., Chua, A. C. G., Newton, R. U., Straker, L. & Olynyk, J. K., Jun 2020, In : Clinical Gastroenterology and Hepatology. 18, 7, p. 1584-1591 8 p.

Research output: Contribution to journalArticle

2019

Detection of HFE Haemochromatosis in the clinic and community using standard erythrocyte tests

Adris, N., Hazedine, S., Bentley, P., Trinder, D., Chua, A. C. G., Powell, L. W., Ramm, L. E., Ramm, G. A. & Olyny, J. K., Feb 2019, In : Blood Cells, Molecules, and Diseases. 74, p. 18-24 7 p.

Research output: Contribution to journalArticle

Open Access
2018
Open Access
2 Citations (Scopus)

Decreased Physical Working Capacity in Adolescents with Non-Alcoholic Fatty Liver Disease Reflects Reduced Iron Bioavailability

Mitchell, T., McKinnon, E., Ayonrinde, O. T., Adams, L. A., Trinder, D., Chua, A., Newton, R., Strakers, L. & Olynyk, J. K., Oct 2018, In : Hepatology. 68, p. 1317A-1318A 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2017

Anaemia of chronic kidney disease: what we know now.

Krishnan, A., Trinder, D., Chua, A. C-G., Chakera, A., Ramm, G. & Olynyk, J., 3 Feb 2017, In : Journal of Renal and Hepatic Disorders. 1, 1, p. 11-19 9 p.

Research output: Contribution to journalReview article

Open Access
File
451 Downloads (Pure)

Liver oxidative stress, apoptosis, and autophagy are increased in a mouse model of iron overload

Chua, A. C. G., Domenichini, A., Delima, R. D., Elsegood, C., Olynyk, J. K. & Trinder, D., Aug 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, p. 4-4 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2016

Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features

Heidari, M., Johnstone, D. M., Bassett, B., Graham, R. M., Chua, A. C. G., House, M. J., Collingwood, J. F., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J. K., Trinder, D. & Milward, E. A., Nov 2016, In : Molecular Psychiatry. 21, 11, p. 1599-1607

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)
15 Citations (Scopus)

Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases

Heidari, M., Gerami, S. H. H., Bassett, B., Graham, R. M. M., Chua, A. C. G., Aryal, R., House, M. J., Collingwood, J. F. F., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J. K. K., Trinder, D., Johnstone, D. M. M. & Milward, E. A. A., Jan 2016, In : Rare Diseases. 4, 1, 11 p., e1198458.

Research output: Contribution to journalArticle

Open Access

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

Kalinowski, D. S., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G. J., Subramaniam, N. V., Trinder, D., Olynyk, J. K., Chua, A., Jansson, P. J., Sahni, S., Lane, D. J. R., Merlot, A. M., Kovacevic, Z., Huang, M. L. H., Lee, C. S. & Richardson, D. R., Apr 2016, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 4, p. 727-748 22 p.

Research output: Contribution to journalReview article

Open Access
File
66 Citations (Scopus)
252 Downloads (Pure)
2013

Dietary Iron Enhances Colonic Inflammation and IL-6/IL-11-Stat3 Signalling Promoting Colonic Tumor Development in Mice

Chua, A., Klopcic, B., Ho, D., Fu, S., Forrest, C., Croft, K., Olynyk, J., Lawrance, I. & Trinder, D., 2013, In : PLoS One. 8, 11, p. 12pp

Research output: Contribution to journalArticle

Open Access
37 Citations (Scopus)
2012

Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice

Delima, R., Chua, A., Tirnitz-Parker, N., Gan, E. K., Croft, K., Graham, R., Olynyk, J. & Trinder, D., 2012, In : Hepatology. 56, p. 585-592

Research output: Contribution to journalArticle

34 Citations (Scopus)

Plasma iron and iron delivery to the tissues

Graham, R., Chua, A. & Trinder, D., 2012, Iron Physiology and Pathophysiology in Humans. Anderson, G. J. & McLaren, G. D. (eds.). United States: Springer Science + Business Media, p. 117-139 (Nutrition and Health).

Research output: Chapter in Book/Conference paperChapter

3 Citations (Scopus)
2011

Liver and Serum Iron: Discrete Regulators of Hepatic Hepcidin Expression

Chua, A., Trinder, D. & Olynyk, J., 2011, In : Hepatology. 54, 1, p. 16-19

Research output: Contribution to journalArticle

7 Citations (Scopus)
2010

Hepatic Iron Loading in Mice Increases Cholesterol Biosynthesis

Graham, R., Chua, A., Carter, K., Delima, R. D., Johnstone, D., Herbison, C., Firth, M., O'Leary, R., Milward, E. A., Olynyk, J. & Trinder, D., 2010, In : Hepatology. 52, 2, p. 462-471

Research output: Contribution to journalArticle

43 Citations (Scopus)

Iron: An emerging factor in colorectal carcinogenesis

Chua, A., Klopcic, B., Lawrance, I., Olynyk, J. & Trinder, D., 2010, In : World Journal of Gastroenterology. 16, 6, p. 663-672

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)

Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis

Chua, A., Delima, R. D., Morgan, E., Herbison, C. E., Tirnitz-Parker, N., Graham, R., Fleming, R. E., Britton, R. S., Bacon, B. R., Olynyk, J. & Trinder, D., 2010, In : Journal of Hepatology. 52, 2010, p. 425-431

Research output: Contribution to journalArticle

15 Citations (Scopus)
2009

The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells

Herbison, C. E., Thorstensen, K., Chua, A., Graham, R., Leedman, P., Olynyk, J. & Trinder, D., 2009, In : American journal of physiology : cell physiology. 297, 6, p. C1567-C1575

Research output: Contribution to journalArticle

42 Citations (Scopus)
2008

Clinical Perspectives on hereditary Hemochromatosis

Ayonrinde, O. T., Milward, E. A., Chua, A. C. G., Trinder, D. & Olynyk, J., 2008, In : Critical Reviews in Clinical Laboratory Sciences. 45, 5, p. 451-484

Research output: Contribution to journalArticle

19 Citations (Scopus)

The Role of Hfe in Transferrin-Bound Iron Uptake by Hepatocytes

Chua, A. C. G., Herbison, C. E., Drake, S. F., Graham, R., Olynyk, J. & Trinder, D., 2008, In : Hepatology. 47, 5, p. 1737-1744

Research output: Contribution to journalArticle

18 Citations (Scopus)

Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron

Graham, R., Reutens, G. M., Herbison, C. E., Delima, R. D., Chua, A. C. G., Olynyk, J. & Trinder, D., 2008, In : Journal of Hepatology. 48, 2, p. 327-334

Research output: Contribution to journalArticle

35 Citations (Scopus)
2007

Liver Iron Transport

Graham, R., Chua, A. C. G., Herbison, C. E., Olynyk, J. & Trinder, D., 2007, In : World Journal of Gastroenterology. 13, 35, p. 4725-4736

Research output: Contribution to journalReview article

78 Citations (Scopus)

The regulation of cellular iron metabolism

Chua, A. C. G., Graham, R., Trinder, D. & Olynyk, J., 2007, In : Critical Reviews in Clinical Laboratory Sciences. 44, 5-6, p. 413-459

Research output: Contribution to journalArticle

115 Citations (Scopus)
2006

Iron uptake by transferrin receptor 1 is regulated by HFE in hepatocytes

Chua, A., Herbison, C. E., Drake, S. F., Graham, R., Olynyk, J. & Trinder, D., 2006, Australian Gastroenterology Week. Farrell, G. (ed.). Adelaide, Australia ed. Australia: Blackwell, Vol. 21. p. A314

Research output: Chapter in Book/Conference paperConference paper

Iron uptake from plasma transferrin by the liver and spleen is reduced in a transferrin receiptor 2 mutant mouse model of haemochromatosis

Chua, A., Morgan, E. H., Herbison, C. E., Delima, R., Graham, R., Fleming, R. E., Olynyk, J. & Trinder, D., 2006, Australian Gastroenterology Week. Farrell, G. (ed.). Adelaide, South Australia ed. Australia: Blackwell, Vol. 21. p. A314

Research output: Chapter in Book/Conference paperConference paper

Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse

Chua, A., Drake, S. F., Herbison, C. E., Olynyk, J., Leedman, P. & Trinder, D., 2006, In : Journal of Hepatology. 44, 1, p. 176-182

Research output: Contribution to journalArticle

13 Citations (Scopus)

Transferrin receptor 2 is involved in both transferrin-bound and non-transferrin bound iron uptake

Graham, R., Herbison, C. E., Chua, A., Olynyk, J. & Trinder, D., 2006, Australian Gastroenterology Week. Farrell, G. (ed.). Adelaide, South Australia ed. Australia: Blackwell, Vol. 21. p. A329

Research output: Chapter in Book/Conference paperConference paper

2004
68 Citations (Scopus)
2003

Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells

Chua, A., Ingram, H. A., Raymond, K. N. & Baker, E., 2003, In : European Journal of Biochemistry. 270, 8, p. 1689-1698

Research output: Contribution to journalArticle

15 Citations (Scopus)

Non-transferrin bound iron uptake by hepatocytes is increased in a HFE knockout mouse model of hereditary haemochromatosis

Chua, A., Olynyk, J. & Trinder, D., 2003, Digestive Disease Week and the 104th Annual Meeting of the American Gastroenterological Association. Brenner, D. A. (ed.). Orlando, Florida, USA ed. United States: Saunders, Vol. 124. p. A-690

Research output: Chapter in Book/Conference paperConference paper

2002

Desferrithiocin is a more potent antineoplastic agent than desferrioxamine

Kicic, A., Chua, A. & Baker, E., 2002, In : British Journal of Pharmacology. 135, p. 1393-1402

Research output: Contribution to journalArticle

21 Citations (Scopus)

Effect of iron status on the absorption of iron by an HFE knockout mouse model of hereditary haemochromatosis

Trinder, D., Drake, S., Lowes, K., Chua, A., Olynyk, J. & Morgan, E., 2002, The American Association for the Study of Liver Diseases: The Liver Meeting. Blei, A. (ed.). Boston, United States ed. United States: Saunders, Vol. 36. p. 334A

Research output: Chapter in Book/Conference paperConference paper

Effect of iron status on the absorption of iron by HFE knockout mouse model of hereditary haemochromatosis

Trinder, D., Drake, S., Lowes, K., Chua, A., Olynyk, J. & Morgan, E. H., 2002, Australian Gastroenterology Week. Okuda, K. (ed.). Adelaide, Australia ed. Australia: Blackwell, Vol. 17. p. A146

Research output: Chapter in Book/Conference paperConference paper

2001

Effect of Iron Chelators on Proliferation and Iron Uptake in Hepatoma Cells

Kicic, A., Chua, A. & Baker, E., 2001, In : Cancer. 92, 12, p. 3093-3110

Research output: Contribution to journalArticle

56 Citations (Scopus)

The Desferrithiocin Class of Fe Chelators: Potential as Antineoplastic Agents

Kicic, A., Chua, A., Schnebli, H. P. & Baker, E., 2001, Bioiron 2001 - World Congress on Iron Metabolism. Cairns, Australia ed. N/A: N/A, Vol. N/A. p. P107

Research output: Chapter in Book/Conference paperConference paper

The Potential of Novel Aroylhydrazones in Iron Chelation Therapy: Studies using the Rate Hepatocyte Model

Chua, A., Richardson, D. R., Savigni, D., Trinder, D. & Baker, E., 2001, Bioiron 2001 - World Congress on Iron Metabolism. Cairns, Australia ed. N/A: N/A, Vol. N/A. p. P83

Research output: Chapter in Book/Conference paperConference paper

1999
19 Citations (Scopus)
1997

Manganese metabolism is impaired in the Belgrade laboratory rat

Chua, A. & Morgan, E., 1997, In : Journal of Comparative Physiology B. 167, p. 361-369

Research output: Contribution to journalArticle

112 Citations (Scopus)
1996
97 Citations (Scopus)

Mechanisms of Manganese Transport in rabbit Erythroid cells

Chua, A., Stonell, L. M., Savigni, D. & Morgan, E., 1996, In : The Journal of Physiology. 493, 1, p. 99-112

Research output: Contribution to journalArticle

25 Citations (Scopus)