Personal profile
Biography
I’m passionate about relating protein structure to function and using this information to: (1) better understand how life functions at a molecular level, and (2) inform the design of new molecules to address medical or technological problems.
I have had the privilege of working on a wide variety of proteins, ranging from microbial enzymes to mammalian nucleic acid binding proteins; gaining expertise in recombinant protein purification, studying protein liquid-liquid phase separation, X-ray crystallography and other biochemical and biophysical techniques.
https://scholar.google.ch/citations?user=ecAk5nIAAAAJ&hl=en
https://www.researchgate.net/profile/Andrew_Marshall28
https://orcid.org/0000-0002-9770-4594
Twitter: @acmarshallphd
Education/Academic qualification
Biochemistry, PhD, Structural and biochemical studies on three Aspergillus fumigatus proteins that present as targets for novel antifungal drugs, University of Adelaide
10 Mar 2014 → 13 Jun 2018
Award Date: 31 Jul 2018
Research expertise keywords
- Protein crystallography
- protein liquid phase separation
- intrinsically disordered proteins
- Enzyme structure, function and inhibition
- Enzymatic catalysis
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Collaborations and top research areas from the last five years
Research output
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Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO
Lindsey, G. L., Hockley, T. K., Gomez, A. V., Marshall, A. C., Brothers, W. R., Finney, C. T., Gross, J., Fox, A. H., Yeo, G. W., Melillo, B., Bond, C. S. & Cravatt, B. F., 19 Feb 2026, In: Cell Chemical Biology. 33, 2, p. 256-267 24 p., e11.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Flexible proteins & phase separation
Marshall, A. C., 24 Nov 2025.Research output: Contribution to conference › Conference presentation/ephemera
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Structural Characteristics and Properties of the RNA-Binding Protein hnRNPK at Multiple Physical States
Le, Q. D., Lewis, A., Dix-Matthews, A., Ringler, P., Duff, A., Whitten, A. E., Atkin, R., Brunner, M., Ho, D., Iyer, K. S., Marshall, A. C., Fox, A. H. & Bond, C. S., 1 Feb 2025, In: International Journal of Molecular Sciences. 26, 3, 22 p., 1356.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural dynamics of IDR interactions in human SFPQ and implications for liquid-liquid phase separation
Koning, H. J., Lai, V., Sethi, A., Chakraborty, S., Ang, C. S., Fox, A. H., Duff, A. P., Whitten, A. E., Marshall, A. C. & Bond, C. S., Jul 2025, In: Acta Crystallographica Section D: Structural Biology. 81, Part 7, p. 357-379 23 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural plasticity of the coiled-coil interactions in human SFPQ
Koning, H. J., Lai, J. Y., Marshall, A. C., Stroeher, E., Monahan, G., Pullakhandam, A., Knott, G. J., Ryan, T. M., Fox, A. H., Whitten, A., Lee, M. & Bond, C. S., 27 Jan 2025, In: Nucleic Acids Research. 53, 2, 15 p., gkae1198.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Citations (Web of Science)
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A liquid protein platform for dynamic bio-inspired reaction compartments
Marshall, A. (Investigator 01)
ARC Australian Research Council
1/07/24 → 26/03/28
Project: Research
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AKTA Pure Liquid Chromatography System
Marshall, A. (Chief Investigator), Marshall, A. (Chief Investigator), Bond, C. (CoPI), Chooi, H. (CoPI), Fox, A. (CoPI), Kretzmann, J. (CoPI), Melville, K. (CoPI), Rudler, D. (CoPI), Sarkar-Tyson, M. (CoPI), Smith, N. (CoPI), Smithers, L. (CoPI), Stubbs, K. (CoPI), Swaminatha Iyer, I. (CoPI), Vrielink, A. (CoPI), Wang, T. (CoPI) & Waters, M. (CoPI)
The University of Western Australia
1/01/25 → 31/12/25
Project: Research
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Core infrastructure: high-throughput nanodrop spectrophotometer
Kretzmann, J. (Investigator 01), Evans, C. (Investigator 02), Choi, Y. S. (Investigator 03), Waryah, C. (Investigator 04), Sarkar-Tyson, M. (Investigator 05), Wang, T. (Investigator 06), Bond, C. (Investigator 07), Vrielink, A. (Investigator 08), Smith, N. (Investigator 09), Lesterhuis, W. (Investigator 10), Marshall, A. (Investigator 11), Stubbs, K. (Investigator 12), Deane, K. (Investigator 13), Chen, K. (Investigator 14), Smithers, L. (Investigator 15), Wylie, B. (Investigator 16), Wang, E. (Investigator 17) & Blancafort, P. (Investigator 18)
NHMRC National Health and Medical Research Council
15/03/24 → 31/12/24
Project: Research
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Multifuge X4R refrigerated centrifuge
Bond, C. (Investigator 01), Vrielink, A. (Investigator 02), Fox, A. (Investigator 03), Stubbs, K. (Investigator 04), Kahler, C. (Investigator 05), Smith, N. (Investigator 06), Kretzmann, J. (Investigator 07), Evans, C. (Investigator 08), Marshall, A. (Investigator 09), Smithers, L. (Investigator 10), Debowski, A. (Investigator 11), Bzdyl, N. (Investigator 12), Chooi, H. (Investigator 13), Fritz, G. (Investigator 14), Small, I. (Investigator 15), Lesterhuis, W. (Investigator 16), Piggott, M. (Investigator 17) & Sarkar-Tyson, M. (Investigator 18)
NHMRC National Health and Medical Research Council
31/03/23 → 31/10/24
Project: Research
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Avestin Emulsiflex C5 Cell Homogeniser for Protein Production
Bond, C. (Investigator 01), Vrielink, A. (Investigator 02), Fox, A. (Investigator 03), Stubbs, K. (Investigator 04), Kahler, C. (Investigator 05), Smith, N. (Investigator 06), Kretzmann, J. (Investigator 07), Marshall, A. (Investigator 08), Evans, C. (Investigator 09), Smithers, L. (Investigator 10), Debowski, A. (Investigator 11), Bzdyl, N. (Investigator 12), Chooi, H. (Investigator 13), Fritz, G. (Investigator 14), Small, I. (Investigator 15), Lesterhuis, W. (Investigator 16), Sarkar-Tyson, M. (Investigator 17) & Piggott, M. (Investigator 18)
NHMRC National Health and Medical Research Council
31/03/23 → 31/10/24
Project: Research
Prizes
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Scholarship to attend 3rd ANSTO Small Angle Scattering Workshop
Marshall, A. (Recipient), Nov 2022
Prize: Award
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The Clifford Bradley Robertson and Gwendoline Florence Robertson Research Fellowship
Marshall, A. (Recipient), 7 Apr 2021
Prize: Fellowship
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School of Biological Sciences Postgraduate All-Round Achievement Award
Marshall, A. (Recipient), 2019
Prize
Activities
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Synchrotron BSX beamline 2026/2 proposals - Grant review
Marshall, A. (Advisor)
2026Activity: Service and engagement › Expert, expert witness or advisor
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Synchrotron MX beamline 2026 CAP proposals - Grant review
Marshall, A. (Advisor)
2026Activity: Service and engagement › Expert, expert witness or advisor
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Adelaide University School of Biological Sciences Seminar Series
Marshall, A. (Keynote speaker/Invited speaker)
20 May 2025Activity: Conferences and workshops › Participation in workshop, seminar or course
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Grant Review Panel: UWA Health & Medical Research Equipment Grants 2025
Marshall, A. (Speaker)
Nov 2025 → Dec 2025Activity: Service and engagement › Expert, expert witness or advisor
Courses
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Master of Biomedical Sciences: Biochemistry and Molecular Biology
Marshall, A. 10/09/18 → 29/05/20
Course
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Press/Media
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UWA researchers awarded $3 million for new research infrastructure
Umana-Membreno, G. A., Tobar, M., Flematti, G., Stubbs, K., Thompson, S., Martyniuk, M., Leopold, M., Low, P., Beringer, J., Chooi, Y.-H., Atkin, R. & Marshall, A. C.
11/01/21 → 12/01/21
2 items of Media coverage
Press/Media: Press / Media