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Andrew Marshall

Dr

 https://orcid.org/0000-0002-9770-4594

  • The University of Western Australia (M310), 35 Stirling Highway,

    6009 Perth

    Australia

  • 11 Citations
  • 2 h-Index
20172019
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Personal profile

Biography

I’m passionate about relating protein structure to function and using this information to: (1) better understand how life functions at a molecular level, and (2) inform the design of new molecules to address biomedical or biotechnological problems. I have had the privilege of working on a wide variety of proteins, ranging from microbial enzymes to mammalian nucleic acid binding proteins; gaining expertise in recombinant protein purification, X-ray crystallography and other biochemical and biophysical techniques.

https://scholar.google.ch/citations?user=ecAk5nIAAAAJ&hl=en
https://www.researchgate.net/profile/Andrew_Marshall28
https://orcid.org/0000-0002-9770-4594
Twitter: @acmarshall88

Education/Academic qualification

Biochemistry, PhD, University of Adelaide

10 Mar 2014 → 13 Jun 2018

Fingerprint Dive into the research topics where Andrew Marshall is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Thioredoxin-Disulfide Reductase Medicine & Life Sciences
Monovalent Cations Chemical Compounds
Reaction intermediates Chemical Compounds
Aspergillus fumigatus Medicine & Life Sciences
Dipeptides Chemical Compounds
Aspergillus Chemical Compounds
Sulfonamides Chemical Compounds
Chymotrypsin Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2017 2019

  • 11 Citations
  • 2 h-Index
  • 7 Article
2 Citations (Scopus)

Structure, mechanism, and inhibition of Aspergillus fumigatus thioredoxin reductase

Marshall, A. C., Kidd, S. E., Lamont-Friedrich, S. J., Arentz, G., Hoffmann, P., Coad, B. R. & Bruning, J. B., Mar 2019, In : Antimicrobial Agents and Chemotherapy. 63, 3, 15 p., e02281-18.

Research output: Contribution to journal › Article

Thioredoxin-Disulfide Reductase
Aspergillus fumigatus
Enzyme Inhibitors
Aspergillus
Growth

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads

Lee, K. J., Tieu, W., Blanco-Rodriguez, B., Paparella, A. S., Yu, J., Hayes, A., Feng, J., Marshall, A. C., Noll, B., Milne, R., Cini, D., Wilce, M. C. J., Booker, G. W., Bruning, J. B., Polyak, S. W. & Abell, A. D., 20 Sep 2019, In : ACS Chemical Biology. 14, 9, p. 1990-1997 8 p.

Research output: Contribution to journal › Article

Sulfonamides
Ligases
Biotin
Staphylococcus aureus
Pharmacokinetics

The role of N-terminal heterocycles in hydrogen bonding to α-chymotrypsin

Schumann, N. C., Bruning, J., Marshall, A. C. & Abell, A. D., Feb 2019, In : Bioorganic & medicinal chemistry letters. 29, 3, p. 396-399

Research output: Contribution to journal › Article

Dipeptides
Chymotrypsin
Hydrogen Bonding
Hydrogen
Hydrogen bonds

Crystal structure of bovine alpha-chymotrypsin in space group P6(5)

Marshall, A. C., Keiller, B. G., Pederick, J. L., Abell, A. D. & Bruning, J. B., Dec 2018, In : Crystals. 8, 12, 7 p., 460.

Research output: Contribution to journal › Article

Open Access
7 Citations (Scopus)

PPAR gamma in complex with an antagonist and inverse agonist: a tumble and trap mechanism of the activation helix

Frkic, R. L., Marshall, A. C., Blayo, A-L., Pukela, T. L., Kamenecka, T. M., Griffin, P. R. & Bruning, J. B., 27 Jul 2018, In : Iscience. 5, p. 69-79 11 p.

Research output: Contribution to journal › Article

Open Access