Allan McKinley

Professor, BSc PhD Cant., MNZIC

  • The University of Western Australia (M313), 35 Stirling Highway, Room 211, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 2210 Citations
  • 26 h-Index
1988 …2019
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Personal profile

Biography

Postdoc. Fellow, Univ. of Texas (Austin), 1987-1990
Assistant Professor/Dreyfus Fellow 1991-1993
Furman University, Greenville, SC, USA

Current projects

Matrix Isolation Studies of Reactive Intermediates

In room G125 we have built a state-of-the-art apparatus for measuring the ESR spectra of molecules trapped in solid neon at 4 K. There are less than half a dozen labs with this type of equipment in the world, no other in Australia. This project would involve using this equipment to synthesize new molecules and characterize their bonding and structure. This is cutting edge work and some of our recent successes CdCH3 [1], ZnCH3 [2] and MgCH3 [3], are published in top international chemistry journals. The results of our studies are important to improve the understanding of models of chemical bonding as well as the chemical mechanisms involved in manufacturing computer chips, wear-resistant coatings, and even the chemical processes occurring in circumstellar dust clouds. Projects in this area could be experimental or involve theoretical calculations or both.
Environmental Chemistry of Contaminated Groundwater.

For some years now we have had a collaboration with Drs Greg Davis and Brad Patterson at the Land and Water division of CSIRO at Floreat. In Australia, water is a key resource. In WA much of our water reserves are underground and very vulnerable to pollution. We have studied the degradation in groundwater of BTEX hydrocarbons (from leaking petrol stations), the mobility of pesticides such as atrazine and fenamiphos in soils and this year we have been evaluating the possibility of employing a new method for remediation of contaminated groundwater using polymer-mats to introduce gaseous reagents into groundwater to promote microbial consumption of the pollutants. We have a provisional patent on this new process. As well as remediation groundwater contamined by BTEX and other votatile organics [4] we have studied denitrification of ammonium contaminated groundwater[5]. There are still many issues to clarify here and we want to extend this work to other pollutants. Projects in this area would involve either the analysis of the chemistry occurring in, or the mathematical modeling of the mass transport phenomena involved with, pilot scale test-rigs for groundwater remediation which are set up at CSIRO in Floreat.
Biological Applications of ESR Spectroscopy.

Radicals play a very important role in biology. It is thought damage from radicals could be responsible for processes such as aging and cancer. We have collaborated with Dr Rob Tuckey in Biochemistry and employed ESR on frozen samples to quantitate the redox state of the adrenodoxin in mitochondria derived from human placenta [6]. A joint project with Dr Tuckey of Biochemistry could be arranged. Also this year we have collaborated with Associate Professor Boris Martinac from Pharmacology and we have developed a new apparatus to measure the ESR spectra of proteins that have been labeled with a nitroxide radical. The label is introduced onto a specific position of the protein backbone by incorporating a cysteine residue at that position using site-directed mutagenesis then binding the nitroxide label selectively to the cycteine residues. By observing the effect on the ESR signals of adding a relaxation agents to the aqueous or lipid phase we can infer the tertiary structure of the protein. This work is only preformed by about three groups in the world [7]. We now have the technology and Associate Professor Martinac has a new ion channel protein that could be interrogated. This project would be best performed as a joint Honours project with the Department of Pharmacology.

References

1. Karakyriakos, E.; Davis, J. R.; Wilson, C. J.; Yates, S. A.; McKinley, A. J.; Knight, L. B. Jr.; Babb R.; Tyler, D. J. (1999) Neon and argon matrix ESR and theoretical studies of the 12CH3Cd, 12CD3Cd, 13CH3Cd, 12CH3111Cd, and 12CH3113Cd Radicals. J. Chem. Phys., 3398-3410

2. McKinley, A. J.; Karakyriakos, E.; Knight, L. B. Jr.; Babb, R.; Williams, A. (1999) Matrix isolation ESR studies of the various isotopomers of the CH3Zn and ZnH radicals; comparisons with ab initio theoretical calculations. J. Phys. Chem. A., 104, 3528-3536

3. McKinley, A. J.; Karakyriakos, E. Neon matrix isolation ESR and theoretical studies of the various isotopomers of the CH3Mg radical. J. Phys. Chem. A. accepted for publication. 10 pages.

4. Patterson, B. M.; Grassi, M. E.; Brill, M.; Davis, G. B.; McKinley, A. J. (2000) In situ bioremediation of ammonium-contaminated groundwater using a sequential oxygen/reductant gas delivery system: laboratory evaluation. accepted as a conference paper for the 2000 Contaminated Site Remediation Conference, Melbourne, 4-8 December

5. Petterson, B. M.; Davis, G. B.; McKinley, A. J. Polymer mats to remove selected VOCs, PAHs and pesticides from groundwater: laboratory column experiments. in preparation.

6. Tuckey, R. C.; McKinley, A. J.; Headlam, M. J. Oxidised adrenodoxin acts as a competitive inhibitor of cytochrome P450scc in mitochondria from human placenta. submitted.

7. See for instance, Perozo, E.; Cortes, D. M.; Cuello, L. G. (1998) Three- dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy. Nature Structural Biology, 5, 459-469

Research

Applications of spectroscopy for the detection and characterization of reactive intermediates
Theoretical modeling of the bonding in radicals Analysis and remediation of conatminated groundwater
Biological applications of Electron Spin Resonance spectroscopy

Keywords

  • Biophysical chemistry
  • Chemical vapour deposition
  • Electron spin resonance spectroscopy
  • Environmental chemistry
  • Industrial chemistry
  • Nanochemistry
  • Spectroscopy at low temperatures
  • Spectroscopy of reactive intermediates

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Paramagnetic resonance Chemical Compounds
Electron spin resonance spectroscopy Chemical Compounds
Groundwater Chemical Compounds
Neon Chemical Compounds
Anions Chemical Compounds
Photoelectron spectroscopy Chemical Compounds
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electron paramagnetic resonance Physics & Astronomy

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1988 2019

A matrix isolation ESR investigation of Mg + -N 2

Hearne, T. S., Wild, D. A. & McKinley, A. J., 14 May 2019, In : Journal of Chemical Physics. 150, 18, 184310.

Research output: Contribution to journalArticle

configuration interaction
Paramagnetic resonance
isolation
electron paramagnetic resonance
Nitrogen

Matrix Isolation ESR and Theoretical Study of ZnN

Hearne, T. S., Yates, S. A., Wild, D. A. & McKinley, A. J., 2 May 2019, In : Journal of Physical Chemistry A. 123, 17, p. 3709-3717 9 p.

Research output: Contribution to journalArticle

Anion Photoelectron Spectroscopy and High Level Ab Initio Calculations of the Halide-Nitric Oxide Dimer Complexes

Lapere, K. M. L., McKinley, A. J. & Wild, D., 1 Jan 2018, In : Australian Journal of Chemistry. 71, 4, p. 265-271 7 p.

Research output: Contribution to journalArticle

Photoelectron spectroscopy
Dimers
Anions
Nitric Oxide
Binding energy
205 Downloads (Pure)

Investigation into the atmospheric degradation of alpha-phellandrene: A computational, experimental and modelling study.

Mackenzie-Rae, F. A., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
monoterpene
nonmethane hydrocarbon
degradation
smog
photooxidation
1 Citation (Scopus)

Spectrum of antibacterial activity and mode of action of a novel tris-stilbene bacteriostatic compound

Man, N. Y. T., Knight, D. R., Stewart, S. G., McKinley, A. J., Riley, T. V. & Hammer, K. A., 2 May 2018, In : Scientific Reports. 8, 9 p., 6912.

Research output: Contribution to journalArticle

Open Access

Projects 1998 2011

Shared Laser Facility

Wild, D., Raston, C., Stubbs, K., Koutsantonis, G., McKinley, A. & Lawrence, W.

Flinders University

1/01/1131/12/11

Project: Research

High Resolution Mass Spectrometry Facility

Ghisalberti, E., Berners-Price, S., Baker, M., Bond, C., Flematti, G., Koutsantonis, G., McKinley, A., Piggott, M., Saunders, S., Spackman, M., Stewart, S., Ogden, M., Humphrey, M., Brown, D., Mancera, R., Mocerino, M., Easton, C. & Sherburn, M.

Curtin University of Technology

1/01/0931/12/09

Project: Research

High Resolution Mass Spectrometry Facility

Ghisalberti, E., Berners-Price, S., Baker, M., Bond, C., Flematti, G., Koutsantonis, G., McKinley, A., Piggott, M., Saunders, S., Spackman, M., Stewart, S., Ogden, M., Humphrey, M., Brown, D., Mancera, R., Mocerino, M., Easton, C. & Sherburn, M.

Australian National University

1/01/0931/12/09

Project: Research

High Resolution Mass Spectrometry Facility

Ghisalberti, E., Berners-Price, S., Baker, M., Bond, C., Flematti, G., Koutsantonis, G., McKinley, A., Piggott, M., Saunders, S., Spackman, M., Stewart, S., Ogden, M., Humphrey, M., Brown, D., Mancera, R., Mocerino, M., Easton, C. & Sherburn, M.

Australian Research Council

1/01/0931/12/09

Project: Research

Integrated Advanced X-Ray Diffraction Facility

Raston, C., Spackman, M., Baker, M., Berners-Price, S., Jayatilaka, D., Koutsantonis, G., Liu, Y., Makha, M., McKinley, A., Piggott, M., St Pierre, T., Stamps, R., Stewart, S., Smith, C., Swaminatha Iyer, K. & Buckley, C.

Australian Research Council

1/01/0731/12/07

Project: Research