Personal profile
Biography
Professor Forrest BSc(Hons), MIT, PhD was born in Western Australia. On completing his Honours, he worked as a research assistant at the Queensland Institute of Medical Research (now known as the QIMR Berghofer). He also completed a Masters in Information Technology and a PhD in Bioinformatics at the Institute for Molecular Bioscience at the University of Queensland. He has been involved in both ‘wet’ and ‘dry’ science, generating and analysing some of the first microarrays used in Australia and invented a strand specific RNA-sequence protocol that heralded the start of the RNA-sequence revolution.
In 2007 he moved to RIKEN Yokohama Japan on a CJ Martin Fellowship. He is currently scientific coordinator of the FANTOM5 (Functional Annotation of the mammalian genome) project consisting of a consortium of over 250 scientists in 20 countries. This has used single-molecule sequencing to generate a map of promoters and enhancers across a large collection of human and mouse primary cells, cancer cell lines and tissues. This work has recently published in the prestigious journal Nature along with a collection of 18 additional satellite papers in specialized journals such as Nature Biotechnology, Genome Research and Blood.
Professor Forrest is currently the Laboratory Head - Systems Biology and Genomics at the Harry Perkins Institute of Medical Research in Perth, Western Australia, and a recipient of a Cancer Research Trust Senior Cancer Research Fellowship.
External positions
Laboratory Head: Systems Biology and Genomics , Harry Perkins Institute of Medical Research
2020 → …
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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ConnectomeDB2025: A rigorously curated, multi-species resource of experimentally supported ligand-receptor interactions
Liu, P., Maezono, S. E. B., Lin, W., Yeow, Y., Liu, Y. Y., Hisham, Y., Hou, R., Ramilowski, J. A. & Forrest, A. R. R., 6 Jan 2026, In: Nucleic Acids Research. 54, D1, p. D546-D554Research output: Contribution to journal › Article › peer-review
Open Access -
Pharmacological targeting and characterization of Voltage-Gated Sodium Channels (VGSCs) expressed in the high-grade glioma microenvironment
Fletcher, E. V., Shard, C., Boyle, Y., Milligan, C. J., Cross, R. S. N., Jones, A. C., Francis, A., Dewdney, B., Barker, M., Rezaeiravesh, S., Ng, Z. Y., Yeow, Y., Kuznetsova, I., Jones, M. E., Ormsby, R. J., Poonnoose, S. I., Valvi, S., Jenkins, M. R., Forrest, A. R. R. & Petrou, S. & 2 others, , 7 Jan 2026, In: BMC Cancer. 26, 20 p., 39.Research output: Contribution to journal › Article › peer-review
Open Access -
Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy
Chin, W. L., Cook, A. M., Chee, J., Principe, N., Hoang, T. S., Kidman, J., Hmon, K. P. W., Yeow, Y., Jones, M. E., Hou, R., Denisenko, E., McDonnell, A. M., Hon, C. C., Moody, J., Anderson, D., Yip, S., Cummins, M. M., Stockler, M. R., Kok, P. S. & Brown, C. & 10 others, , 21 Jan 2025, In: Cell Reports Medicine. 6, 1, p. 1-18 18 p., 101882.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Citations (Scopus) -
FBP1 controls liver cancer evolution from senescent MASH hepatocytes
The Liver Cancer Collaborative, 9 Jan 2025, In: Nature. 637, 8045, p. 461-469 9 p., 15691.Research output: Contribution to journal › Article › peer-review
27 Link opens in a new tab Citations (Scopus) -
Inhibition of the Caveolin-1 pathway promotes apoptosis and overcomes pan-tyrosine kinase inhibitor resistance in hepatocellular carcinoma
Liver Cancer Collaborative, Kabir, T. D., Stuart, L. M., Li, J., Hou, R., Choi, Y. S., Bastow, E. R., Beveridge, D. J., Spalding, L., Redfern, A. D., Yeoh, G. C., Forrest, A., Woo, A. J. & Leedman, P. J., Dec 2025, In: Cell Death & Disease. 16, 20 p., 561.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Citations (Web of Science)
Datasets
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Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential
Carlessi, R. (Creator), Denisenko, E. (Creator), Boslem, E. (Creator), Köhn-Gaone, J. (Creator), Main, N. (Creator), Abu Bakar, N. D. B. (Creator), Shirolkar, G. (Creator), Jones, M. (Creator), Poppe, D. (Contributor), Dwyer, B. J. (Creator), Jackaman, C. (Creator), Tjiam, C. (Creator), Lister, R. (Creator), Karin, M. (Creator), Fallowfield, J. A. (Creator), Kendall, T. J. (Creator), Forbes, S. J. (Creator), Olynyk, J. K. (Creator), Yeoh, G. (Creator), Forrest, A. (Creator), Ramm, G. (Creator), Febbraio, M. A. (Creator) & Tirnitz-Parker, N. (Creator), Gene Expression Omnibus (NCBI), 12 Apr 2022
DOI: 10.26182/bhy9-q334, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE200366
Dataset
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Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows
Denisenko, E. (Creator), Guo, B. (Creator), Jones, M. (Creator), Hou, R. (Creator), De Kock, L. (Creator), Lassmann, T. (Creator), Poppe, D. (Contributor), Clement, O. (Creator), Simmons, R. (Creator), Lister, R. (Creator) & Forrest, A. (Creator), Gene Expression Omnibus (NCBI), 11 May 2020
DOI: 10.26182/ybd2-6755, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE141115
Dataset
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Transcription start site profiling of 15 anatomical regions of the Macaca mulatta central nervous system
Francescatto, M. (Creator), Lizio, M. (Creator), Philippens, I. (Creator), Bontrop, R. (Creator), Sakai, M. (Creator), Watanabe, S. (Creator), Itoh, M. (Creator), Hasegawa, A. (Creator), Lassmann, T. (Creator), Severin, J. (Creator), Harshbarger, J. (Creator), Abugessaisa, I. (Creator), Kasukawa, T. (Creator), Carninci, P. (Creator), Hayashizaki, Y. (Creator), Forrest, A. (Creator), Kawaji, H. (Creator), Rizzu, P. (Creator) & Heutink, P. (Creator), Scientific Data, 31 Oct 2017
DOI: 10.1038/sdata.2017.163, https://www.nature.com/articles/sdata2017163
Dataset
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Immune dynamics of dengue infection
Forrest, A. (Investigator 01) & Hou, R. (Investigator 02)
NHMRC National Health and Medical Research Council
1/02/26 → 31/01/29
Project: Research
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Transforming Medical Discovery: Next-Generation High-Performance Computing Infrastructure for Accelerated Translational Research
Dwivedi, G. (Investigator 01), Forrest, A. (Investigator 02), Lister, R. (Investigator 03), Pham, D. S. (Investigator 04), Chan, K. Y. (Investigator 05), Soon, S. (Investigator 06), Maiorana, A. (Investigator 07), Moniruzzaman, M. (Investigator 08), Bartlett, B. (Investigator 09), Afsharan, H. (Investigator 10), Shukla, D. (Investigator 11) & Ali, A. (Investigator 12)
Department of Health (Western Australia)
1/09/25 → 28/08/26
Project: Research
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From Coding to Cryptic - Exploring the RNA World of Inclusion Body Myositis (IBM)
Johari, M. (Investigator 01), Needham, M. (Investigator 02), Forrest, A. (Investigator 03), Savarese, M. (Investigator 04) & Roos, A. (Investigator 05)
6/01/25 → 24/12/26
Project: Research
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Building translational capacity in WA; Establishing the tools needed to develop treatments for Australian children with muscle disease.
Taylor, R. (Investigator 01), Ravenscroft, G. (Investigator 02), Clayton, J. (Investigator 03), Kuznetsova, I. (Investigator 04), Elaskalani, O. (Investigator 05), Endersby, R. (Investigator 06) & Forrest, A. (Investigator 07)
Stan Perron Charitable Foundation
2/07/23 → 4/07/27
Project: Research
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Genomics WA NCRIS 2023 stage 1 OPEX
Saxena, A. (Investigator 01), Forrest, A. (Investigator 02), Lister, R. (Investigator 03), Kahler, C. (Investigator 04) & Martino, D. (Investigator 05)
Department of Education (Australia)
1/07/23 → 30/06/28
Project: Research
Prizes
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Channel 7 Telethon Grant
Barry, K. (Recipient), Valente, F. (Recipient), Thornton, R. (Recipient), Ong, H. T. (Recipient), Forrest, A. (Recipient), Mulders, W. (Recipient), Atlas, M. (Recipient) & Clark, S. (Recipient), 2022
Prize
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Fellow of the Australian Academy of Health and Medical Sciences
Forrest, A. (Recipient), 2020
Prize: Fellow of the Australian Academy of Health and Medical Sciences
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Eureka Prize for Excellence in international scientific collaboration
Forrest, A. (Recipient), 2016
Prize
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Press/Media
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DUG Technology Ltd: Harry Perkins Institute of Medical Research increases big data analysis with DUG McCloud partnership
31/10/20
1 item of Media coverage
Press/Media: Press / Media