Alfred Tay

Dr, BSc DSc NSW

  • The University of Western Australia (M504), 35 Stirling Highway,

    6009 Perth

    Australia

  • 260 Citations
  • 10 h-Index
20082018
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Research Output 2008 2018

  • 260 Citations
  • 10 h-Index
  • 29 Article
  • 2 Letter
  • 1 Conference paper
  • 1 Comment/debate
2018

Draft genome sequences of 42 Helicobacter pylori isolates from rural regions of South India

Shetty, V., Lamichhane, B., Chua, E. G., Ballal, M. & Tay, C. Y., 1 Feb 2018, In : Genome Announcements. 6, 5, e01486-17

Research output: Contribution to journalArticle

Open Access
Helicobacter pylori
India
Genome
Molecular Evolution
Rural Population
2 Citations

Genomic analysis of oral Campylobacter concisus strains identified a potential bacterial molecular marker associated with active Crohn's disease

Liu, F., Ma, R., Tay, C. Y. A., Octavia, S., Lan, R., Chung, H. K. L., Riordan, S. M., Grimm, M. C., Leong, R. W., Tanaka, M. M., Connor, S. & Zhang, L., 1 Dec 2018, In : Emerging Microbes and Infections. 7, 1, 64

Research output: Contribution to journalArticle

Open Access
Campylobacter
Crohn Disease
Inflammatory Bowel Diseases
Plasmids
Chromosomes, Human, 6-12 and X
1 Citations

Hyperendemic dengue transmission and identification of a locally evolved DENV-3 lineage, Papua New Guinea 2007-2010

Luang-Suarkia, D., Mitja, O., Ernst, T., Bennett, S., Tay, A. C. Y., Hayes, R., Smith, D. W. & Imrie, A., 1 Mar 2018, In : PLoS Neglected Tropical Diseases. 11, 4, p. e0005488 15 p.

Research output: Contribution to journalArticle

Open Access
File
Papua New Guinea
Dengue
Severe Dengue
Disease Outbreaks
Epidemiology

In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species

Bauwens, E., Joosten, M., Taganna, J., Rossi, M., Debraekeleer, A., Tay, A., Peters, F., Backert, S., Fox, J., Ducatelle, R., Remaut, H., Haesebrouck, F. & Smet, A., 1 Dec 2018, In : Scientific Reports. 8, 1, 15453

Research output: Contribution to journalArticle

Open Access
Helicobacter
Computer Simulation
Proteomics
Stomach
Membrane Proteins

Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence

Smet, A., Yahara, K., Rossi, M., Tay, A., Backert, S., Armin, E., Fox, J. G., Flahou, B., Ducatelle, R., Haesebrouck, F. & Corander, J., 1 Oct 2018, In : ISME Journal. 12, 10, p. 2518-2531 14 p.

Research output: Contribution to journalArticle

Helicobacter
Stomach
stomach
divergence
Helicobacter pylori
2017
6 Citations

A novel isolation protocol and probe-based RT-PCR for diagnosis of gastric infections with the zoonotic pathogen Helicobacter suis

Blaecher, C., Bauwens, E., Tay, A., Peters, F., Dobbs, S., Dobbs, J., Charlett, A., Ducatelle, R., Haesebrouck, F. & Smet, A., 1 Jun 2017, In : Helicobacter. 22, 3, 11 p., e12369

Research output: Contribution to journalArticle

Helicobacter heilmannii
Zoonoses
Real-Time Polymerase Chain Reaction
Stomach
Linezolid
5 Citations

Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection

Debowski, A. W., Walton, S. M., Chua, E-G., Tay, A. C-Y., Liao, T., Lamichhane, B., Himbeck, R., Stubbs, K. A., Marshall, B. J., Fulurija, A. & Benghezal, M., Jun 2017, In : PLoS Pathogens. 13, 6, 21 p., 1006464

Research output: Contribution to journalArticle

Open Access
Open Access
Coptotermes acinaciformis
Isoptera
intermediate hosts
Eggs
Abbreviata
1 Citations

Quantum changes in Helicobacter pylori gene expression accompany host-adaptation

Chua, E-G., Wise, M. J., Khosravi, Y., Seow, S-W., Amoyo, A. A., Pettersson, S., Peters, F., Tay, C-Y., Perkins, T. T., Loke, M-F., Marshall, B. J. & Vadivelu, J., Feb 2017, In : DNA Research. 24, 1, p. 37-49 13 p.

Research output: Contribution to journalArticle

Open Access
2016
2 Citations

Assessment of Risk and Sero-Prevalence of Helicobacter pylori Colonization among Remote Orang Asli Tribes in Peninsula Malaysia

Thevakumar, K., Chandren, J. R., Perez-Perez, G. I., Chua, E. G., Teh, L. K., Salleh, M. Z., Tan, J. A. M. A., Leow, A. H. R., Goh, K. L., Tay, A. C. Y., Marshall, B. J., Vadivelu, J., Loke, M. F. & Wong, L. P., 21 Jul 2016, In : PLoS One. 11, 7, 15 p., 0159830

Research output: Contribution to journalArticle

Open Access
tribal peoples
Helicobacter pylori
Malaysia
Population Groups
seroprevalence
7 Citations

Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study

Safarchi, A., Octavia, S., Luu, L. D. W., Tay, C. Y., Sintchenko, V., Wood, N., Marshall, H., Mcintyre, P. & Lan, R., 25 Jul 2016, In : Vaccine. 34, 34, p. 3967-3971

Research output: Contribution to journalArticle

Bordetella pertussis
Coinfection
mixed infection
single nucleotide polymorphism
Single Nucleotide Polymorphism
5 Citations

Comparative Genomics Revealed Multiple Helicobacter pylori Genes Associated with Biofilm Formation In Vitro

Wong, E. H. J., Ng, C. G., Chua, E., Tay, A. C. Y., Peters, F., Marshall, B. J., Ho, B., Goh, K. L., Vadivelu, J. & Loke, M. F., 21 Nov 2016, In : PLoS One. 11, 11, p. 1-16 16 p., 0166835

Research output: Contribution to journalArticle

Open Access
9 Citations

Divergence between the Highly Virulent Zoonotic Pathogen Helicobacter heilmannii and Its Closest Relative, the Low-Virulence “Helicobacter ailurogastricus” sp. nov.

Joosten, M., Linden, S., Rossi, M., Tay, A. C. Y., Skoog, E., Padra, M., Peters, F., Perkins, T., Vandamme, P., Van Nieuwerburgh, F., D'Herde, K., Van Den Broeck, W., Flahou, B., Deforce, D., Ducatelle, R., Marshall, B., Haesebrouck, F. & Smet, A., Jan 2016, In : Infection and Immunity. 84, 1, p. 293-306 14 p.

Research output: Contribution to journalArticle

Open Access
Helicobacter heilmannii
Helicobacter
Zoonoses
Virulence
Gastric Mucosa
3 Citations

Evolution of variable number tandem repeats and its relationship with genomic diversity in Salmonella typhimurium

Fu, S., Octavia, S., Wang, Q., Tanaka, M. M., Tay, C. Y., Sintchenko, V. & Lan, R., 26 Dec 2016, In : Frontiers in Microbiology. 7, DEC, 12 p., 2002

Research output: Contribution to journalArticle

Open Access
Minisatellite Repeats
Salmonella typhimurium
Single Nucleotide Polymorphism
Alleles
Disease Outbreaks
10 Citations

Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity

Chung, H. K. L., Tay, A., Octavia, S., Chen, J., Liu, F., Ma, R., Lan, R., Riordan, S. M., Grimm, M. C. & Zhang, L., 2 Dec 2016, In : Scientific Reports. 6, 38442

Research output: Contribution to journalArticle

Open Access
Campylobacter
Gastroenteritis
Inflammatory Bowel Diseases
Virulence
Genome

Helicobacter pylori overcomes natural immunity in repeated infections

Stenström, B., Windsor, H. M., Fulurija, A., Benghezal, M., Kumarasinghe, M. P., Kimura, K., Tay, C. Y., Viiala, C. H., Ee, H. C., Lu, W., Schoep, T. D., Webberley, K. M. & Marshall, B. J., Nov 2016, In : Clinical Case Reports. 4, 11, p. 1026-1033 8 p.

Research output: Contribution to journalArticle

Open Access
Innate Immunity
Helicobacter pylori
Vaccines
Helicobacter Infections
Infection
10 Citations

Temporal changes in BEXSERO® antigen sequence type associated with genetic lineages of Neisseria meningitidis over a 15-year period in Western Australia

Mowlaboccus, S., Perkins, T., Smith, H., Sloots, T., Tozer, S., Prempeh, L., Tay, A. C. Y., Peters, F., Speers, D., Keil, A. D. & Kahler, C., 29 Jun 2016, In : PLoS One. 11, 6

Research output: Contribution to journalArticle

Open Access
Neisseria meningitidis
Western Australia
antigens
Antigens
vaccines
2015
8 Citations

Metronidazole-triazole conjugates: Activity against Clostridium difficile and parasites

Jarrad, A. M., Karoli, T., Debnath, A., Tay, C. Y., Huang, J. X., Kaeslin, G., Elliott, A. G., Miyamoto, Y., Ramu, S., Kavanagh, A. M., Zuegg, J., Eckmann, L., Blaskovich, M. A. T. & Cooper, M. A., 28 Aug 2015, In : European Journal of Medicinal Chemistry. 101, p. 96-102 7 p.

Research output: Contribution to journalArticle

Open Access
Clostridium
Triazoles
Clostridium difficile
Metronidazole
Parasites

Nano-engineered flexible pH sensor for point-of-care urease detection

Sardarinejad, A., Maurya, D. K., Alameh, K., Tay, A. C. Y. & Marshall, B., 2015, Proceedings of SPIE: Micro+Nano Materials, Devices, and Systems. United States: SPIE, Vol. 9668, p. 1-10

Research output: Chapter in Book/Conference paperConference paper

pH sensors
Urease
Electrodes
Monitoring
Urea
4 Citations

Novel Moraxella catarrhalis prophages display hyperconserved non-structural genes despite their genomic diversity

Ariff, A., Wise, M., Kahler, C., Tay, A. C. Y., Peters, F., Perkins, T. & Chang, B., 24 Oct 2015, In : BMC Genomics. 16, 1, p. 1-19 19 p., 860

Research output: Contribution to journalArticle

Open Access
Prophages
Moraxella (Branhamella) catarrhalis
Genes
Bacteriophages
Virulence
22 Citations

Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model

Safarchi, A., Octavia, S., Luu, L. D. W., Tay, A. C. Y., Sintchenko, V., Wood, N., Marshall, H., Mcintyre, P. & Lan, R., 17 Nov 2015, In : Vaccine. 33, 46, p. 6277-6281 5 p.

Research output: Contribution to journalArticle

Bordetella pertussis
Coinfection
mixed infection
Acellular Vaccines
Vaccines
17 Citations

The complete methylome of Helicobacter pylori UM032

Lee, W. C., Anton, B. P., Wang, S., Baybayan, P., Singh, S., Ashby, M., Chua, E., Tay, A. C. Y., Thirriot, F., Loke, M. F., Goh, K. L., Marshall, B., Roberts, R. J. & Vadivelu, J., 2015, In : BMC Genomics. 16, 424, p. 1-9

Research output: Contribution to journalArticle

Open Access
Helicobacter pylori
DNA Restriction-Modification Enzymes
Methyltransferases
Human Genome
Methylation
2014
21 Citations

Comparative analysis of the full genome of the Helicobacter pylori isolate, Sahul64, identifies genes of high divergence

Lu, W., Wise, M., Tay, A. C. Y., Windsor, H., Marshall, B., Peacock, C. & Perkins, T., 2014, In : Journal of Bacteriology. 196, 5, p. 1073-1083

Research output: Contribution to journalArticle

Open Access
Helicobacter pylori
Genome
Genomic Islands
Genes
Virulence
1 Citations

Expressions of P-glycoprotein in treatment – Resistant Helicobacter pylori patients

Omar, M., Crowe, A., Tay, A. C. Y. & Hughes, J., 2014, In : Journal of Applied Biomedicine. 12, 4, p. 263–269

Research output: Contribution to journalArticle

2013
5 Citations

Arthropod intermediate hosts of abbreviata antarctica (Nematoda: Physalopteridae) in Australia

King, C., Jones, H. & Tay, A. C. Y., 2013, In : Journal of Parasitology. 99, 4, p. 708-711

Research output: Contribution to journalArticle

17 Citations

Choosing a Benchtop Sequencing Machine to Characterise Helicobacter pylori Genomes

Perkins, T., Tay, A. C. Y., Thirriot, F. & Marshall, B., 2013, In : PLoS One. 8, 6, p. 11pp

Research output: Contribution to journalArticle

Open Access
Helicobacter pylori
Genes
Genome
Ions
Technology
11 Citations

Comparing the genomes of Helicobacter pylori clinical strain UM032 and Mice-adapted derivatives

Khosravi, Y., Rehvathy, V., Wee, W. Y., Wang, S., Baybayan, P., Singh, S., Ashby, M., Ong, J., Amoyo, A. A., Seow, S. W., Choo, S. W., Perkins, T., Chua, E., Tay, A. C. Y., Marshall, B., Loke, M. F., Goh, K. L., Pettersson, S. & Vadivelu, J., 2013, In : Gut Pathogens. 5, 1, p. 6pp

Research output: Contribution to journalArticle

Open Access
Helicobacter pylori
Genome
Host Specificity
DNA Restriction-Modification Enzymes
Allergy and Immunology
1 Citations

Letter: Curing Helicobacter pylori infection in a clinical setting - Authors' reply

Thirriot, F. & Tay, A. C. Y., 2013, In : Alimentary Pharmacology and Therapeutics. 37, 7, p. 758-759

Research output: Contribution to journalLetter

2012
33 Citations

Helicobacter pylori eradication in Western Australia using novel quadruple therapy combinations

Tay, A. C. Y., Windsor, H., Thirriot, F., Lu, W., Conway, C., Perkins, T. & Marshall, B., Dec 2012, In : Alimentary pharmacology & therapeutics. 36, 11/12, p. 1076-1083

Research output: Contribution to journalArticle

Open Access
Western Australia
Rifabutin
Helicobacter pylori
Anti-Bacterial Agents
Ciprofloxacin
2009
49 Citations

Population structure of Helicobacter pylori among ethnic groups in Malaysia: recent acquisition of the bacterium by the Malay population

Tay, A. C. Y., Mitchell, H., Dong, Q. J., Goh, K. L., Dawes, I. W. & Lan, R. T., 2009, In : BMC Microbiology. 9, p. Article number 126, 13pp

Research output: Contribution to journalArticle

Open Access
Malaysia
Ethnic Groups
Helicobacter pylori
Bacteria
Population
2008
10 Citations
Fimbriae Proteins
Genomic Islands
Vibrio cholerae
Vibrio
Genetic Recombination