• The University of Western Australia (M517), 35 Stirling Highway,

    6009 Perth

    Australia

  • 5782 Citations
  • 40 h-Index
20052020
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Research Output 2005 2020

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Article
2010
88 Citations (Scopus)

Common Genetic Variants near the Brittle Cornea Syndrome Locus ZNF469 Influence the Blinding Disease Risk Factor Central Corneal Thickness

Lu, Y., Dimasi, D. P., Hysi, P. G., Hewitt, A. W., Burdon, K. P., Toh, T., Ruddle, J. B., Li, Y. J., Mitchell, P., Healey, P. R., Montgomery, G. W., Hansell, N., Spector, T. D., Martin, N. G., Young, T. L., Hammond, C. J., Macgregor, S., Craig, J. E. & Mackey, D., 2010, In : PLoS Genetics. 6, p. -

Research output: Contribution to journalArticle

Open Access
252 Citations (Scopus)

Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma

Thorleifsson, G., Walters, G. B., Hewitt, A. W., Masson, G., Helgason, A., Dewan, A., Sigurdsson, A., Jonasdottir, A., Gudjonsson, S. A., Magnusson, K. P., Stefansson, H., Lam, D. S. C., Tam, P. O. S., Gudmundsdottir, G. J., Southgate, L., Burdon, K. P., Gottfredsdottir, M. S., Aldred, M. A., Mitchell, P., St Clair, D. & 27 othersCollier, D. A., Tang, N., Sveinsson, O., Macgregor, S., Martin, N. G., Cree, A. J., Gibson, J., Macleod, A., Jacob, A., Ennis, S., Young, T. L., Chan, J. C. N., Karwatowski, W. S. S., Hammond, C. J., Thordarson, K., Zhang, M., Wadelius, C., Lotery, A. J., Trembath, R. C., Pang, C. P., Hoh, J., Craig, J. E., Kong, A., Mackey, D., Jonasson, F., Thorsteinsdottir, U. & Stefansson, K., 2010, In : Nature Genetics. 42, p. 906-+

Research output: Contribution to journalArticle

89 Citations (Scopus)

Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo

Ikram, M. K., Xueling, S., Jensen, R. A., Cotch, M. F., Hewitt, A. W., Ikram, M. A., Wang, J. J., Klein, R., Klein, B. E. K., Breteler, M. M. B., Cheung, N., Liew, G., Mitchell, P., Uitterlinden, A. G., Rivadeneira, F., Hofman, A., De Jong, P. T. V. M., Van Duijn, C. M., Kao, L., Cheng, C. Y. & 37 othersSmith, A. V., Glazer, N. L., Lumley, T., Mcknight, B., Psaty, B. M., Jonasson, F., Eiriksdottir, G., Aspelund, T., Harris, T. B., Launer, L. J., Taylor, K. D., Li, X. H., Iyengar, S. K., Xi, Q. S., Sivakumaran, T. A., Mackey, D., Macgregor, S., Martin, N. G., Young, T. L., Bis, J. C., Wiggins, K. L., Heckbert, S. R., Hammond, C. J., Andrew, T., Fahy, S., Attia, J., Holliday, E. G., Scott, R. J., Islam, F. M. A., Rotter, J. I., Mcauley, A. K., Boerwinkle, E., Tai, E. S., Gudnason, V., Siscovick, D. S., Vingerling, J. R. & Wong, T. Y., 2010, In : PLoS Genetics. 6, p. -

Research output: Contribution to journalArticle

Open Access
102 Citations (Scopus)

Genome-wide association identifies ATOH7 as a major gene determining human optic disc size

Macgregor, S., Hewitt, A. W., Hysi, P. G., Ruddle, J. B., Medland, S. E., Henders, A. K., Gordon, S. D., Andrew, T., Mcevoy, B., Sanfilippo, P. G., Carbonaro, F., Tah, V., Li, Y. J., Bennett, S. L., Craig, J. E., Montgomery, G. W., Tran-Viet, K. N., Brown, N. L., Spector, T. D., Martin, N. G. & 3 othersYoung, T. L., Hammond, C. J. & Mackey, D., 2010, In : Human Molecular Genetics. 19, p. 2716-2724

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

Novel quantitative trait loci for central corneal thickness identiWed by candidate gene analysis of osteogenesis imperfecta genes

Dimasi, DP., Chen, JY., Hewitt, AW., Klebe, SK., Davey, R., Stirling, J., Thompson, E., Forbes, R., Tan, TY., Savarirayan, R., Mackey, D., Healey, PR., Mitchell, P., Burdon, KP. & Craig, JE., 2010, In : Human Genetics. 127, p. 33-34

Research output: Contribution to journalArticle

2 Citations (Scopus)

Primary open angle glaucoma due to T377M MYOC: Population mapping of a Greek founder mutation in Northwestern Greece

Kitsos, G., Petrou, Z., Grigoriadou, M., Samples, JR., Hewitt, AW., Kokotas, H., Giannoulia-Karantana, A., Mackey, D., Wirtz, MK., Moschou, M., Ioannidis, JP. & Petersen, MB., 2010, In : Clinical Ophthalmology. 4, p. 171-178

Research output: Contribution to journalArticle

8 Citations (Scopus)

System disease associations of familial and sporadic glaucoma: the Glaucoma Inheritance Study in Tasmania

Hewitt, AJ., Wu, J., Green, CM., Lai, T., Kearns, LS., Craig, JE. & Mackey, D., 2010, In : Acta Ophthalmologica. 88, 1, p. 70-74

Research output: Contribution to journalArticle

8 Citations (Scopus)

Tag SNPs detect association of the CYP1B1 gene with primary open angle glaucoma

Burdon, KP., Hewitt, AW., Mackey, D., Mitchell, P. & Craig, JE., 2010, In : Molecular Vision. 16, p. 2286-2293

Research output: Contribution to journalArticle

84 Citations (Scopus)

The heritability of ocular traits

Sanfilippo, P. G., Hewitt, A. W., Hammond, C. J. & Mackey, D., 2010, In : Survey of Ophthalmology. 55, 6, p. 561-583

Research output: Contribution to journalArticle

64 Citations (Scopus)

The Path to Open-Angle Glaucoma Gene Discovery: Endophenotypic Status of Intraocular Pressure, Cup-to-Disc Ratio, and Central Corneal Thickness

Charlesworth, J., Kramer, P. L., Dyer, T., Diego, V., Samples, J. R., Craig, J. E., Mackey, D., Hewitt, A. W., Blangero, J. & Wirtz, M. K., 2010, In : Investigative ophthalmology & visual science. 51, p. 3509-3514

Research output: Contribution to journalArticle

2009
32 Citations (Scopus)

Effect of birth Parameters on Retinal Vascular Caliber: The Twins Eye Study in Tasmania

Sun, C., Ponsonby, AL., Wong, TY., Brown, SA., Kearns, LS., Cochrane, J., Mackinnon, JR., Ruddle, JB., Hewitt, AW., Liew, G., Dwyer, T., Scurrah, K. & Mackey, D., 2009, In : Hypertension. 53, 3, p. 487-493

Research output: Contribution to journalArticle

149 Citations (Scopus)

Genetic influences on handedness: data from 25,732 Australian and Dutch twin families

Medland, SE., Duffy, DL., Wright, MJ., Geffen, GM., Hay, DA., Levy, D., Van-Beijsterveldt, CE., Willemsen, G., Townsend, GC., White, V., Hewitt, A. W., Mackey, D., Bailey, JM., Slutske, WS., Nyholt, DR., Treloar, SA., Martin, NG. & Boomsma, DI., 2009, In : Neuropsychologia. 47, p. 330-337

Research output: Contribution to journalArticle

31 Citations (Scopus)

Heritability of central corneal thickness in nuclear families

Landers, J., Hewitt, AW., Dimasi, DP., Charlesworth, JC., Straga, T., Mills, RAD., Savarirayan, R., Mackey, D., Burdon, KP. & Craig, JE., 2009, In : Investigative ophthalmology & visual science. 50, p. 4087-4090

Research output: Contribution to journalArticle

4 Citations (Scopus)

Mortality in primary open angle glaucoma: "two cupped discs and a funeral"

Hewitt, AW., Sanfilippo, P., Ring, MA., Craig, JE. & Mackey, D., 2009, In : Eye. 24, p. 59-63

Research output: Contribution to journalArticle

4 Citations (Scopus)

Primary open glaucoma in subjects harbouring the predicted GLC1L haplotype reveals a normotensive phenotype

Sherwin, JC., Hewitt, AW., Bennett, SL., Baird, PN., Craig, JE. & Mackey, D., 2009, In : Clinical and Experimental Ophthalmology. 37, p. 201-207

Research output: Contribution to journalArticle

26 Citations (Scopus)

Quantitative genetic analysis of retinal vascular caliber: the Australian Twins Eye Study

Sun, C., Zhu, G., Wong, TY., Hewitt, AW., Ruddle, JB., Hodgson, L., Montgomery, GW., Young, TL., Hammond, CJ., Craig, JE., Martin, NG., He, M. & Mackey, D., 2009, In : Hypertension. 54, p. 788-795

Research output: Contribution to journalArticle

33 Citations (Scopus)

Twins Eye Study in Tasmania (TEST): Rationale and Methodology to Recruit and Examine Twins

Mackey, D., Mackinnon, J. R., Brown, S. A., Kearns, L. S., Ruddle, J. B., Sanfilippo, P. G., Sun, C., Hammond, C. J., Young, T. L., Martin, N. G. & Hewitt, A. W., 2009, In : Twin Research and Human Genetics. 12, 5, p. 441-454

Research output: Contribution to journalArticle

Tasmania
Twin Studies
Registries
Eye Diseases
Vision Disorders
2008
126 Citations (Scopus)

Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people

Hewitt, A. W., Sharma, S., Burdon, K. P., Wang, J. J., Baird, P. N., Dimasi, D. P., Mackey, D., Mitchell, P. & Craig, J. E., 2008, In : Human Molecular Genetics. 17, 5, p. 710-716

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Penetrance
Exfoliation Syndrome
Ciliary Body
Iris
28 Citations (Scopus)

Genetic analysis of the clusterin gene in pseudoexfoliation syndrome

Sharma, S., Mcmellon, A. E., Mackey, D., Craig, J. E., Burdon, K. P., Hewitt, A. W., Wang, J. J. & Mitchell, P., 2008, In : Molecular Vision. 14, p. 1727-1736

Research output: Contribution to journalArticle

Exfoliation Syndrome
Clusterin
Genes
Single Nucleotide Polymorphism
Protein-Lysine 6-Oxidase
42 Citations (Scopus)
215 Downloads (Pure)

Genetic Dissection of Myopia. Evidence for Linkage of Ocular Axial Length to Chromosome 5q

Zhu, G., Hewitt, A. W., Ruddle, J. B., Kearns, L. S., Brown, S. A., Mackinnon, J. R., Chen, C. Y., Hammond, C. J., Craig, J. E., Montgomery, G. W., Martin, N. G. & Mackey, D., 2008, In : Ophthalmology. 115, 6, p. 1053-1057

Research output: Contribution to journalArticle

File
Eye Axial Length
Twin Studies
Myopia
Dissection
Chromosomes
15 Citations (Scopus)

Genetic isolates in ophthalmic diseases

Sherwin, J. C., Hewitt, A. W., Ruddle, J. B. & Mackey, D., 2008, In : Ophthalmic Genetics. 29, 4, p. 149-161

Research output: Contribution to journalArticle

Eye Diseases
Population
Keratoconus
Gene Flow
Chromosome Mapping
17 Citations (Scopus)

Heritability of the iridotrabecular angle width measured by optical coherence tomography in chinese children: The Guangzhou twin eye study

He, M., Ge, J., Wang, D., Zhang, J., Hewitt, A. W., Hur, Y. M., Mackey, D. & Foster, P. J., 2008, In : Investigative Ophthalmology and Visual Science. 49, 4, p. 1356-1361

Research output: Contribution to journalArticle

Twin Studies
Optical Coherence Tomography
Iris
Registries
Drainage
68 Citations (Scopus)

Myocilin allele-specific glaucoma phenotype database

Hewitt, A. W., Mackey, D. & Craig, J. E., 2008, In : Human Mutation. 29, 2, p. 207-211

Research output: Contribution to journalArticle

Glaucoma
Alleles
Databases
Phenotype
Mutation
43 Citations (Scopus)
207 Downloads (Pure)

The natural history of OPA1-related autosomal dominant optic atrophy

Cohn, A. C., Toomes, C., Hewitt, A. W., Kearns, L. S., Inglehearn, C. F., Craig, J. E. & Mackey, D., 2008, In : British Journal of Ophthalmology. 92, 10, p. 1333-1336

Research output: Contribution to journalArticle

File
Autosomal Dominant Optic Atrophy
Natural History
Visual Acuity
Mutation
Longitudinal Studies
2007
79 Citations (Scopus)

Autosomal Dominant Optic Atrophy: Penetrance and Expressivity in Patients With OPA1 Mutations

Cohn, A. C., Toomes, C., Potter, C., Towns, K. V., Hewitt, A. W., Inglehearn, C. F., Craig, J. E. & Mackey, D., 2007, In : American Journal of Ophthalmology. 143, 4, p. 656-662

Research output: Contribution to journalArticle

Autosomal Dominant Optic Atrophy
Penetrance
Pedigree
Mutation
Siblings
17 Citations (Scopus)

Heritable features of the optic disc: a novel twin method for determining genetic significance

Hewitt, A. W., Poulsen, J. P., Alward, W. L. M., Bennett, S. L., Budde, W. M., Cooper, R. L., Craig, J. E., Fingert, J. H., Foster, P. J., Garway-Heath, D. F., Green, C. M., Hammond, C. J., Hayreh, S. S., Jonas, J. B., Kaufman, P. L., Miller, N. R., Morgan, W., Newman, N. J., Quigley, H. A., Samples, J. R. & 3 othersSpaeth, G. L., Pesudovs, K. & Mackey, D., 2007, In : Investigative Ophthalmology and Visual Science. 48, 6, p. 2469-2475

Research output: Contribution to journalArticle

Optic Disk
Optic Nerve
Dizygotic Twins
Inborn Genetic Diseases
Monozygotic Twins
52 Citations (Scopus)

How significant is a family history of glaucoma Experience from the glaucoma inheritance study in Tasmania

Green, C. M., Kearns, L. S., Wu, J., Barbour, J. M., Wilkinson, R. M., Ring, M. A., Craig, J. E., Wong, T. L., Hewitt, A. W. & Mackey, D., 2007, In : Clinical and Experimental Ophthalmology. 35, 9, p. 793-799

Research output: Contribution to journalArticle

Tasmania
Glaucoma
Twin Studies
Gonioscopy
Primary Open Angle Glaucoma
11 Citations (Scopus)

Investigation of founder effects for the Thr377Met Myocilin mutation in glaucoma families from differing ethnic backgrounds

Hewitt, A. W., Samples, J. R., Allingham, R. R., Jarvela, I., Kitsos, G., Krishnadas, S. R., Richards, J. E., Lichter, P. R., Petersen, M. B., Sundaresan, P., Wiggs, J. L., Mackey, D. & Wirtz, M. K., 2007, In : Molecular Vision. 13, p. 487-492

Research output: Contribution to journalArticle

Founder Effect
Glaucoma
Greece
Mutation
HapMap Project
10 Citations (Scopus)

Myocilin Gly252Arg mutation and glaucoma of intermediate severity in Caucasian individuals

Hewitt, A. W., Bennett, S. L., Richards, J. E., Dimasi, D. P., Booth, A. P., Inglehearn, C., Anwar, R., Yamamoto, T., Fingert, J. H., Heon, E., Craig, J. E. & Mackey, D., 2007, In : Archives of Ophthalmology. 125, 1, p. 98-104

Research output: Contribution to journalArticle

Glaucoma
Mutation
Pedigree
Haplotypes
trabecular meshwork-induced glucocorticoid response protein
45 Citations (Scopus)

PAX6 mutations may be associated with high myopia

Hewitt, A. W., Kearns, L. S., Jamieson, R. V., Williamson, K. A., Van Heyningen, V. & Mackey, D., 2007, In : Ophthalmic Genetics. 28, 3, p. 179-182

Research output: Contribution to journalArticle

Myopia
Mutation
Refractive Errors
Aniridia
Phenotype
36 Citations (Scopus)

Prevalence of CYP1B1 mutations in Australian patients with primary congenital glaucoma

Dimasi, D. P., Hewitt, A. W., Straga, T., Pater, J., Mackinnon, J. R., Elder, J. E., Casey, T., Mackey, D. & Craig, J. E., 2007, In : Clinical Genetics. 72, 3, p. 255-260

Research output: Contribution to journalArticle

Glaucoma
Mutation
Population
South Australia
Mutation Rate
4 Citations (Scopus)

Screening for glaucomatous disc changes prior to diagnosis of glaucoma in myocilin pedigrees

Bennett, S. L., Hewitt, A. W., Poulsen, J. L., Kearns, L. S., Morgan, J. E., Craig, J. E. & Mackey, D., 2007, In : Archives of Ophthalmology. 125, 1, p. 112-116

Research output: Contribution to journalArticle

Pedigree
Glaucoma
Mutation
Optic Disk
trabecular meshwork-induced glucocorticoid response protein
13 Citations (Scopus)

The optic nerve head in Myocilin glaucoma

Hewitt, A. W., Bennett, S. L., Fingert, J. H., Cooper, R. L., Stone, E. M., Craig, J. E. & Mackey, D., 2007, In : Investigative Ophthalmology and Visual Science. 48, 1, p. 238-243

Research output: Contribution to journalArticle

Optic Disk
Glaucoma
Mutation
Open Angle Glaucoma
Atrophy
2006
54 Citations (Scopus)

A Glaucoma Case-control Study of the WDR36 Gene D658G Sequence Variant

Hewitt, A. W., Dimasi, D. P., Mackey, D. & Craig, J. E., 2006, In : American Journal of Ophthalmology. 142, 2, p. 324-325

Research output: Contribution to journalArticle

Glaucoma
Case-Control Studies
Genes
Tasmania
Mutation
16 Citations (Scopus)

A myocilin Gln368STOP homozygote does not exhibit a more severe glaucoma phenotype than heterozygous cases

Hewitt, A. W., Bennett, S. L., Dimasi, D. P., Craig, J. E. & Mackey, D., 2006, In : American Journal of Ophthalmology. 141, 2, p. 402-403

Research output: Contribution to journalArticle

Homozygote
Glaucoma
Phenotype
Mutation
Optic Disk
61 Citations (Scopus)

Complex genetics of complex traits: the case of primary open-angle glaucoma

Hewitt, A. W., Craig, J. E. & Mackey, D., 2006, In : Clinical and Experimental Ophthalmology. 34, 5, p. 472-484

Research output: Contribution to journalArticle

Genetic Predisposition to Disease
Natural History
Glaucoma
Population
Genes
32 Citations (Scopus)

Disease severity of familial glaucoma compared with sporadic glaucoma

Wu, J., Hewitt, A. W., Green, C. M., Ring, M. A., Mccartney, P. J., Craig, J. E. & Mackey, D., 2006, In : Archives of Ophthalmology. 124, 7, p. 950-954

Research output: Contribution to journalArticle

Glaucoma
Tasmania
Optic Disk
Visual Fields
Intraocular Pressure
2 Citations (Scopus)

Familial transmission risk of infantile glaucoma in Australia

Hewitt, A. W., Mackinnon, J. R., Giubilato, A., Elder, J. E., Craig, J. E. & Mackey, D., 2006, In : Ophthalmic Genetics. 27, 3, p. 93-97

Research output: Contribution to journalArticle

Glaucoma
Pedigree
Phenotype
South Australia
Cataract
17 Citations (Scopus)

The role of the Met98Lys optineurin variant in inherited optic nerve diseases

Craig, J. E., Hewitt, A. W., Dimasi, D. P., Howell, N., Toomes, C., Cohn, A. C. & Mackey, D., 2006, In : British Journal of Ophthalmology. 90, 11, p. 1420-1424

Research output: Contribution to journalArticle

Autosomal Dominant Optic Atrophy
Optic Nerve Diseases
Leber's Hereditary Optic Atrophy
Open Angle Glaucoma
Low Tension Glaucoma
2005
97 Citations (Scopus)

Central corneal thickness is highly heritable: The twin eye studies

Toh, T., Liew, S. H. M., Mackinnon, J. R., Hewitt, A. W., Poulsen, J. L., Spector, T. D., Gilbert, C. E., Craig, J. E., Hammond, C. J. & Mackey, D., 2005, In : Investigative Ophthalmology and Visual Science. 46, 10, p. 3718-3722

Research output: Contribution to journalArticle

Twin Studies
Dizygotic Twins
Monozygotic Twins
Corneal Pachymetry
Tasmania
21 Citations (Scopus)

Genotypic and phenotypic spectrum of X-linked retinoschisis in Australia

Hewitt, A. W., Fitzgerald, L. M., Scotter, L. W., Mulhall, L. E., Mckay, J. D. & Mackey, D., 2005, In : Clinical and Experimental Ophthalmology. 33, 3, p. 233-239

Research output: Contribution to journalArticle

Retinoschisis
Pedigree
Mutation
Genes
Exons
23 Citations (Scopus)

The telomere of human chromosome 1p contains at least two independent autosomal dominant congenital cataract genes

Mckay, J. D., Patterson, B., Craig, J. E., Russell-Eggitt, I. M., Wirth, M. G., Burdon, K. P., Hewitt, A. W., Cohn, A. C., Kerdraon, Y. & Mackey, D., 2005, In : British Journal of Ophthalmology. 89, 7, p. 831-834

Research output: Contribution to journalArticle

Telomere
Human Chromosomes
Cataract
Genes
Haplotypes