Personal profile
Biography
Professor Aleksandra Filipovska is a NHMRC Investigator, Louis Landau Chair in Child Health Research at the University of Western Australia and the Telethon Kids Institute in Perth, Australia and a Deputy Director of the ARC Centre of Excellence for Synthetic Biology.
She received her PhD from the University of Otago, New Zealand and she was a NZ Foundation for Research, Science and Technology Fellow at the MRC Mitochondrial Biology Unit in Cambridge, the United Kingdom. Her group focuses on the regulation of gene expression by RNA-binding proteins and protein synthesis in models of disease and multi-omic technologies to elucidate their molecular functions. She develops treatments for metabolic and cardiovascular diseases. Aleksandra is an elected fellow of the Australian Academy of Health and Medical Sciences.
External positions
Deputy Director, ARC Centre of Excellence in Synthetic Biology
31 Oct 2020 → 31 Oct 2027
Research expertise keywords
- RNA biology
- RNA-binding proteins
- Mitochondrial Diseases
- RNA Editing
- Mitochondria
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Collaborations and top research areas from the last five years
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Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle
Bond, S. T., King, E. J., Walker, S. M., Yang, C., Liu, Y., Liu, K. H., Zhuang, A., Jurrjens, A. W., Fang, H. A., Formosa, L. E., Nath, A. P., Carmona, S. R., Inouye, M., Duong, T., Huynh, K., Meikle, P. J., Crawford, S., Ramm, G., Elahee Doomun, S. N. & de Souza, D. P. & 6 others, , Dec 2025, In: Nature Communications. 16, 1, 21 p., 2338.Research output: Contribution to journal › Article › peer-review
Open Access13 Link opens in a new tab Citations (Scopus) -
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels
Miranda, M., Mesaros, A., Scrima, N., Pérard, L., Kuznetsova, I., Purrio, M., Atanassov, I., Filipovska, A., Mourier, A., Larsson, N. G. & Kühl, I., Dec 2025, In: Life science alliance. 8, 12, 17 p., e202302563.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
TANGO2 binds crystallin alpha B and its loss causes desminopathy
Stentenbach, M., Hughes, L. A., Fagan, S. V., Payne, B., Rudler, D. L., Siira, S. J., McCubbin, T., Chopin, A., Perks, K. L., Ermer, J. A., Hendry, J., Er, T. S., Balasubramaniam, S., Eliades, J. A., Hool, L. C., Packer, N. H., Moh, E. S. X., Padman, B. S., Rackham, O. & Filipovska, A., 6 Jun 2025, (E-pub ahead of print) In: Nature Communications. 16, 17 p., 5261.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
The Vsr-like protein FASTKD4 regulates the stability and polyadenylation of the MT-ND3 mRNA
Yang, X., Stentenbach, M., Hughes, L. A., Siira, S. J., Lau, K., Hothorn, M., Martinou, J. C., Rackham, O. & Filipovska, A., 28 Feb 2025, In: Nucleic Acids Research. 53, 4, gkae1261.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
Unique architectural features of mammalian mitochondrial protein synthesis
Rackham, O., Saurer, M., Ban, N. & Filipovska, A., Jan 2025, In: Trends in Cell Biology. 35, 1, p. 11-23 13 p.Research output: Contribution to journal › Review article › peer-review
4 Link opens in a new tab Citations (Scopus)
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AI for Little Lives: Fast-Tracking Cures for Childhood Diseases
Filipovska, A. (Investigator 01), Rackham, O. (Investigator 02) & Siira, S. (Investigator 03)
Stan Perron Charitable Foundation
23/01/26 → 31/01/27
Project: Research
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RNA Mass Spectrometry Platform
Davidovich, C. (Investigator 01), Schittenhelm, R. (Investigator 02), Purcell, A. (Investigator 03), Rossjohn, J. (Investigator 04), Carroll, J. (Investigator 05), Knott, G. (Investigator 06), Zhang, Q. (Investigator 07), Lynn, D. (Investigator 08), Snel, M. (Investigator 09), Shackleton, M. (Investigator 10), Filipovska, A. (Investigator 11), Bredy, T. (Investigator 12), Walkley, C. (Investigator 13), Carroll, L. (Investigator 14) & CROAGH, D. (Investigator 15)
MRFF Medical Research Future Fund
30/06/24 → 29/06/29
Project: Research
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New therapeutics for paediatric metabolic diseases
Filipovska, A. (Investigator 01), Rackham, O. (Investigator 02), Siira, S. (Investigator 03) & Stentenbach, M. (Investigator 04)
Department of Health (Western Australia)
1/01/24 → 31/12/26
Project: Research
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ARC Centre of Excellence in Synthetic Biology
Paulsen, I. (Investigator 01), Filipovska, A. (Investigator 02), Nielsen, L. (Investigator 03), Parker, R. (Investigator 04), Neilan, B. (Investigator 05), Alexandrov, K. (Investigator 06), Sherman, B. (Investigator 07) & Jackson, C. (Investigator 08)
ARC Australian Research Council
1/01/20 → 8/11/27
Project: Research
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Australian Biosecurity Approved Arrangement Equipment Upgrade to Support Laboratory Animal Based Research.
Chapple, S. (Chief Investigator), Filipovska, A. (CoPI), Hool, L. (CoPI), Pavlos, N. (CoPI), Rodger, J. (CoPI) & Tang, A. (CoPI)
The University of Western Australia
12/01/25 → 21/09/25
Project: Research