• The University of Western Australia (M519), 35 Stirling Highway, Room 2.04 and 2.02, L Block, QEII Medical Centre

    6009 Perth

    Australia

  • The University of Western Australia (M504), 35 Stirling Highway, Room 2.04 and 2.02, L Block, QEII Medical Centre

    6009 Perth

    Australia

  • 402 Citations
  • 13 h-Index
19962020

Research output per year

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Personal profile

Biography

Dr Alec Redwood completed a Bachelor of Applied Science with Honours and a PhD researching cytokine responses to fungal infections at Curtin University. He then worked as a Research Assistant for Dr Bruce Robinson in the Department of Medicine before being awarded a Fellowship with the School of Oral Health Sciences at UWA. Dr Redwood became involved in the Pest Animal Control Cooperative Research Centre researching the use of murine cytomegalovirus (MCMV) as a vaccine vector for virally vectored immunocontraception. Since 2005 he has been studying various aspects of the fundamental biology of MCMV. 

In 2014 he took a position at IIID at Murdoch University assessing the role of T cell responses to small drug molecules.  In 2018 he returned to UWA to use his skills in T cell biology to study responses to neo-epitopes in cancer with NCARD.

Roles and responsibilities

Dr Redwood is a supervisor of 1 PhD student and co-supervises 1 other PhD student.

Funding overview

Dr Redwood has had several NHMRC grants and currently holds one NHMRC grant and one grant funded by DARPA

Research

Dr Redwood is interested in understanding the interactions between viruses and their hosts, especially how viral genetics control their responses to the host, and how host genetics control their response to the virus. He is currently researching MCMV a common a herpesvirus found in mice that is used as a model for the human equivalent virus. Because most hosts are infected with multiple strains of MCMV Dr Redwood is studying how these strains associate with each other and how this association affects viral pathogenesis.

 

Dr Redwood is also investigating the use of MCMV as a vaccine vector.  This work is funed by DARPA. 

 

Dr Redwood is also investigating T cell responses to neo-epitopes in cancer

Research expertise keywords

  • Immunology—cellular
  • Viruses—BACs
  • Viruses—herpes
  • Viruses—vaccines

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Research Output

Membrane association of a model CD4+ T-cell vaccine antigen confers enhanced yet incomplete protection against murid herpesvirus-4 infection

Yunis, J., Redwood, A. J., Belz, G. T. & Stevenson, P. G., Apr 2020, In : Immunology and Cell Biology. 98, 4, p. 332-343 12 p.

Research output: Contribution to journalArticle

Open Access
  • Applications of immunopharmacogenomics: Predicting, preventing, and understanding immune-mediated adverse drug reactions

    Karnes, J. H., Miller, M. A., White, K. D., Konvinse, K. C., Pavlos, R. K., Redwood, A. J., Peter, J. G., Lehloenya, R., Mallal, S. A. & Phillips, E. J., 6 Jan 2019, In : Annual Review of Pharmacology and Toxicology. 59, p. 463-486 24 p.

    Research output: Contribution to journalReview article

  • 10 Citations (Scopus)

    HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

    Konvinse, K. C., Trubiano, J. A., Pavlos, R., James, I., Shaffer, C. M., Bejan, C. A., Schutte, R. J., Ostrov, D. A., Pilkinton, M. A., Rosenbach, M., Zwerner, J. P., Williams, K. B., Bourke, J., Martinez, P., Rwandamuriye, F., Chopra, A., Watson, M., Redwood, A. J., White, K. D., Mallal, S. A. & 1 others, Phillips, E. J., Jul 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 183-192 10 p.

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Murine cytomegalovirus disseminates independently of CX3CR1, CCL2 or its m131/m129 chemokine homologue

    Farrell, H. E., Bruce, K., Redwood, A. J. & Stevenson, P. G., 1 Dec 2019, In : The Journal of general virology. 100, 12, p. 1695-1700 6 p.

    Research output: Contribution to journalArticle

  • The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors

    Železnjak, J., Lisnić, V. J., Popović, B., Lisnić, B., Babić, M., Halenius, A., L'Hernault, A., Roviš, T. L., Hengel, H., Erhard, F., Redwood, A. J., Vidal, S. M., Dölken, L., Krmpotić, A. & Jonjić, S., 5 Aug 2019, In : The Journal of Experimental Medicine. 216, 8, p. 1809-1827 19 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Citations (Scopus)

    Projects