• The University of Western Australia (M519), 35 Stirling Highway, Room 2.04 and 2.02, L Block, QEII Medical Centre

    6009 Perth

    Australia

  • The University of Western Australia (M504), 35 Stirling Highway, Room 2.04 and 2.02, L Block, QEII Medical Centre

    6009 Perth

    Australia

  • 343 Citations
  • 11 h-Index
19962021
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Personal profile

Biography

Dr Alec Redwood completed a Bachelor of Applied Science with Honours and a PhD researching cytokine responses to fungal infections at Curtin University. He then worked as a Research Assistant for Dr Bruce Robinson in the Department of Medicine before being awarded a Fellowship with the School of Oral Health Sciences at UWA. Dr Redwood became involved in the Pest Animal Control Cooperative Research Centre researching the use of murine cytomegalovirus (MCMV) as a vaccine vector for virally vectored immunocontraception. Since 2005 he has been studying various aspects of the fundamental biology of MCMV. 

In 2014 he took a position at IIID at Murdoch University assessing the role of T cell responses to small drug molecules.  In 2018 he returned to UWA to use his skills in T cell biology to study responses to neo-epitopes in cancer with NCARD.

Roles and responsibilities

Dr Redwood is a supervisor of 1 PhD student and co-supervises 1 other PhD student.

Funding overview

Dr Redwood has had several NHMRC grants and currently holds one NHMRC grant and one grant funded by DARPA

Research

Dr Redwood is interested in understanding the interactions between viruses and their hosts, especially how viral genetics control their responses to the host, and how host genetics control their response to the virus. He is currently researching MCMV a common a herpesvirus found in mice that is used as a model for the human equivalent virus. Because most hosts are infected with multiple strains of MCMV Dr Redwood is studying how these strains associate with each other and how this association affects viral pathogenesis.

 

Dr Redwood is also investigating the use of MCMV as a vaccine vector.  This work is funed by DARPA. 

 

Dr Redwood is also investigating T cell responses to neo-epitopes in cancer

Keywords

  • Immunology—cellular
  • Viruses—BACs
  • Viruses—herpes
  • Viruses—vaccines

Fingerprint Dive into the research topics where Alec Redwood is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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mice Agriculture & Biology
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2019

HLA-A*32: 01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

Konvinse, K. C., Trubiano, J. A., Pavlos, R., James, I., Shaffer, C. M., Bejan, C. A., Schutte, R. J., Ostrov, D. A., Pilkinton, M. A., Rosenbach, M., Zwerner, J. P., Williams, K. B., Bourke, J., Martinez, P., Rwandamuriye, F., Chopra, A., Watson, M., Redwood, A. J., White, K. D., Mallal, S. A. & 1 othersPhillips, E. J., Jul 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 183-192 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Shared peptide binding of HLA Class i and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk allele

Pavlos, R., McKinnon, E. J., Ostrov, D. A., Peters, B., Buus, S., Koelle, D., Chopra, A., Schutte, R., Rive, C., Redwood, A., Restrepo, S., Bracey, A., Kaever, T., Myers, P., Speers, E., Malaker, S. A., Shabanowitz, J., Jing, Y., Gaudieri, S., Hunt, D. F. & 4 othersCarrington, M., Haas, D. W., Mallal, S. & Phillips, E. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 8653.

Research output: Contribution to journalArticle

Open Access
Nevirapine
HLA Antigens
Hypersensitivity
Alleles
Skin
1 Citation (Scopus)
Open Access
Muromegalovirus
Cytomegalovirus
Salivary Glands
Genetic Recombination
Infection
15 Citations (Scopus)

Inhibition of the TRAIL Death Receptor by CMV Reveals Its Importance in NK Cell-Mediated Antiviral Defense

Verma, S., Loewendorf, A., Wang, Q., Mcdonald, B., Redwood, A. & Benedict, C. A., 2014, In : PLoS Pathogens. 10, p. 1-11

Research output: Contribution to journalArticle

Open Access

Molecular Evolution of Murine Cytomegalovirus Genomes

Redwood, A., Shellam, G. & Smith, L., 2013, Cytomegaloviruses: From Molecular Pathogenesis to Intervention. Reddehase, M. J. (ed.). UK: Caister Academic Press, p. 23-38

Research output: Chapter in Book/Conference paperOther chapter contribution

Projects 2003 2021