Alan James

Clinical Professor

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth

    Australia

  • 17655 Citations
  • 54 h-Index
1993 …2023
If you made any changes in Pure these will be visible here soon.

Research Output 1993 2019

2019
3 Citations (Scopus)

A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma

Fricker, M., Gibson, P. G., Powell, H., Simpson, J. L., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M. & Baines, K. J., 1 Jul 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 51-60.e11

Research output: Contribution to journalArticle

Sputum
Asthma
Azithromycin
Genes
Phenotype
1 Citation (Scopus)

Early-life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitization

the investigators of the TAHS and MACS, 8 Aug 2019, In : Clinical and Experimental Allergy. 49, 3, p. 331-340 10 p.

Research output: Contribution to journalArticle

Siblings
Single Nucleotide Polymorphism
Meta-Analysis
Logistic Models
Alleles
15 Citations (Scopus)

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

SpiroMeta consortium, International COPD Genetics Consortium & Understanding Society Scientific Group, 25 Feb 2019, In : Nature Genetics. 51, 3, p. 494-505 12 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Phenotype
Lung
Genetic Loci
Genetic Heterogeneity

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

Liu, C. T., Merino, J., Rybin, D., DiCorpo, D., Benke, K. S., Bragg-Gresham, J. L., Canouil, M., Corre, T., Grallert, H., Isaacs, A., Kutalik, Z., Lahti, J., Marullo, L., Marzi, C., Rasmussen-Torvik, L. J., Rocheleau, G., Rueedi, R., Scapoli, C., Verweij, N., Vogelzangs, N. & 30 othersWillems, S. M., Yengo, L., Bakker, S. J. L., Beilby, J., Hui, J., Kajantie, E., Müller-Nurasyid, M., Rathmann, W., Balkau, B., Bergmann, S., Eriksson, J. G., Florez, J. C., Froguel, P., Harris, T., Hung, J., James, A. L., Kavousi, M., Miljkovic, I., Musk, A. W., Palmer, L. J., Peters, A., Roussel, R., van der harst, P., van Duijn, C. M., Vollenweider, P., Barroso, I., Prokopenko, I., Dupuis, J., Meigs, J. B. & Bouatia-Naji, N., Jul 2019, In : Scientific Reports. 9, 1, 9439.

Research output: Contribution to journalArticle

Open Access
Genome-Wide Association Study
Fasting
Glucose
Type 2 Diabetes Mellitus
Observation
Western Australia
Obstructive Sleep Apnea
Delivery of Health Care
Life Style
Behavior Therapy
5 Citations (Scopus)

Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma

Taylor, S. L., Leong, L. E. X., Mobegi, F. M., Choo, J. M., Wesselingh, S., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Baraket, M., Marks, G. B., Gibson, P. G., Rogers, G. B. & Simpson, J. L., 1 Aug 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 3, p. 309-317 9 p.

Research output: Contribution to journalArticle

Azithromycin
Haemophilus influenzae
Microbial Drug Resistance
Asthma
Macrolides
12 Citations (Scopus)

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Understanding Society Scientific Group, 1 Mar 2019, In : Nature Genetics. 51, 3, p. 481-493 13 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Lung
Genome-Wide Association Study
Mortality
Pharmaceutical Preparations
3 Citations (Scopus)

Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment

Donovan, G. M., Elliot, J. G., Boser, S. R., Green, F. H. Y., James, A. L. & Noble, P. B., Mar 2019, In : Journal of Applied Physiology. 126, 3, p. 599-606 8 p.

Research output: Contribution to journalArticle

2018
1 Citation (Scopus)

Airway smooth muscle proliferation and inflammation in asthma

James, A. L., Noble, P. B., Drew, S. A., Mauad, T., Bai, T. R., Abramson, M. J., McKay, K. O., Green, F. H. Y. & Elliot, J. G., 1 Oct 2018, In : Journal of Applied Physiology. 125, 4, p. 1090-1096 7 p.

Research output: Contribution to journalArticle

Smooth Muscle
Asthma
Inflammation
Smooth Muscle Myocytes
Cell Size
6 Citations (Scopus)
170 Downloads (Pure)

Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma

Asai, Y., Eslami, A., van Ginkel, C. D., Akhabir, L., Wan, M., Yin, D., Ellis, G., Ben-Shoshan, M., Marenholz, I., Martino, D., Ferreira, M. A., Allen, K., Mazer, B., de Groot, H., de Jong, N. W., Gerth van Wijk, R., Dubois, A. E. J., Grosche, S., Ashley, S., Rüschendorf, F. & 20 othersKalb, B., Beyer, K., Nöthen, M. M., Lee, Y-A., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J. S., Melles, R. B., Hong, X., Wang, X., Hui, J., Musk, A. W. B., Hunter, M., James, A. L., Koppelman, G. H., Sandford, A. J., Clarke, A. E. & Daley, D., 1 Apr 2018, In : The Journal of Allergy and Clinical Immunology. 141, 4, p. 1513-1516

Research output: Contribution to journalLetter

Open Access
File
14 Citations (Scopus)

Childhood respiratory risk factor profiles and middle-age lung function: A prospective cohort study from the first to sixth decade

Bui, D. S., Walters, H. E., Burgess, J. A., Perret, J. L., Bui, M. Q., Bowatte, G., Lowe, A. J., Russell, M. A., Thompson, B. R., Hamilton, G. S., James, A. L., Giles, G. G., Thomas, P. S., Jarvis, D., Svanes, C., Garcia-Aymerich, J., Erbas, B., Frith, P. A., Allen, K. J., Abramson, M. J. & 2 othersLodge, C. J. & Dharmage, S. C., 1 Sep 2018, In : Annals of the American Thoracic Society. 15, 9, p. 1057-1066 10 p.

Research output: Contribution to journalArticle

Cohort Studies
Asthma
Prospective Studies
Chronic Obstructive Pulmonary Disease
Lung
1 Citation (Scopus)
15 Downloads (Pure)
Open Access
File
Continuous Positive Airway Pressure
Obstructive Sleep Apnea
Depression
Therapeutics
Anhedonia
7 Citations (Scopus)

Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner

Wang, K. C., Larcombe, A. N., Berry, L. J., Morton, J. S., Davidge, S. T., James, A. L. & Noble, P. B., 25 Jan 2018, In : Clinical Science. 132, 2, p. 273-284

Research output: Contribution to journalArticle

Fetal Development
Growth
Asthma
Lung
Pregnancy
45 Citations (Scopus)

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program, 1 Oct 2018, In : Nature Genetics. 50, 10, p. 1412-1425 14 p.

Research output: Contribution to journalArticle

Open Access
Blood Pressure
Cardiovascular Diseases
Genetic Association Studies
Life Style
Hypertension
9 Citations (Scopus)

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

LifeLines Cohort Study & CHARGE Inflammation Working Group, 1 Nov 2018, In : American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to journalArticle

C-Reactive Protein
Genome
Inflammation
Mendelian Randomization Analysis
Genome-Wide Association Study
19 Citations (Scopus)

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Asai, Y., Eslami, A., van Ginkel, C. D., Akhabir, L., Wan, M., Ellis, G., Ben-Shoshan, M., Martino, D., Ferreira, M. A., Allen, K., Mazer, B., de Groot, H., de Jong, N. W., Gerth van Wijk, R. N., Dubois, A. E. J., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J. S. & 11 othersMelles, R. B., Hong, X., Wang, X., Hui, J., Musk, A. W., Hunter, M., James, A. L., Koppelman, G. H., Sandford, A. J., Clarke, A. E. & Daley, D., Mar 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 991-1001

Research output: Contribution to journalArticle

Open Access
Peanut Hypersensitivity
Food Hypersensitivity
Genome-Wide Association Study
Meta-Analysis
Single Nucleotide Polymorphism
4 Citations (Scopus)

Independent and combined effects of airway remodelling and allergy on airway responsiveness

Wang, K. C., Le Cras, T. D., Larcombe, A. N., Zosky, G. R., Elliot, J. G., James, A. L. & Noble, P. B., 14 Feb 2018, In : Clinical Science. 132, 3, p. 327-338 CS20171386.

Research output: Contribution to journalArticle

Airway Remodeling
Hypersensitivity
Ovalbumin
Smooth Muscle
Doxycycline
5 Citations (Scopus)

Inflammation-dependent and independent airway remodelling in asthma

Elliot, J. G., Noble, P. B., Mauad, T., Bai, T. R., Abramson, M. J., McKay, K. O., Green, F. H. Y. & James, A. L., 1 Dec 2018, In : Respirology. 23, 12, p. 1138-1145 8 p.

Research output: Contribution to journalArticle

Airway Remodeling
Smooth Muscle
Asthma
Inflammation
Basement Membrane
43 Citations (Scopus)

Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology

Taylor, S. L., Leong, L. E. X., Choo, J. M., Wesselingh, S., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Baraket, M., Marks, G. B., Gibson, P. G., Simpson, J. L. & Rogers, G. B., 1 Jan 2018, In : Journal of Allergy and Clinical Immunology. 141, 1, p. 94-103.e15

Research output: Contribution to journalArticle

Open Access
Microbiology
Microbiota
Asthma
Phenotype
Sputum

Influence of gene-by-sex interaction on time-to-asthma onset: a large-scale genome-wide meta-analysis

Veil, R., Mohamdi, H., Granell, R., Ege, M., Freidin, M. B., Imboden, M., James, A., Jarvis, D., Khusnutdinova, E. K., Laprise, C., Margaritte-Jeannin, P., Ogorodova, L. O., Sarnowski, C., Marie-Helene, Henderson, D. A. J., Karunas, A. S., Von Mutius, E., Probst-Hensch, N. M., Leynaert, B., Demenais, F. & 1 othersBouzigon, E., 15 Sep 2018, In : European Respiratory Journal. 52, 3 p.

Research output: Contribution to journalAbstract/Meeting Abstract

71 Citations (Scopus)

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Australian Asthma Genetics Consortium Collaborators, 1 Jan 2018, In : Nature Genetics. 50, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

Asthma
Seasonal Allergic Rhinitis
Genome-Wide Association Study
Autoimmune Diseases
Meta-Analysis

No association between sleep apnoea and macular telangiectasia type 2 and its markers of severity and progression: a case–control study and retrospective cohort study

Lee, M. G., Marshall, N. S., Clemons, T. E., Hunter, M. L., James, A. L., Grunstein, R. R., Nguyen, V., Campain, A. & Gillies, M. C., 19 Aug 2018, In : Clinical and Experimental Ophthalmology. 6 p.

Research output: Contribution to journalArticle

Telangiectasis
Sleep Apnea Syndromes
Cohort Studies
Retrospective Studies
Obstructive Sleep Apnea
130 Downloads (Pure)
Open Access
File
Western Australia
Smoking
Asthma
Lung
Chronic Obstructive Pulmonary Disease
7 Citations (Scopus)

Pathophysiology of severe asthma: We've only just started

King, G. G., James, A., Harkness, L. & Wark, P. A. B., Mar 2018, In : Respirology. 23, 3, p. 262-271

Research output: Contribution to journalReview article

Asthma
Health Services
Therapeutics
Clinical Studies
1 Citation (Scopus)

Pleiotropy of cardiometabolic syndrome with obesity-related anthropometric traits determined using empirically derived kinships from the Busselton Health Study

Cadby, G., Melton, P. E., McCarthy, N. S., Almeida, M., Williams-Blangero, S., Curran, J. E., VandeBerg, J. L., Hui, J., Beilby, J., Musk, A. W., James, A. L., Hung, J., Blangero, J. & Moses, E. K., 2018, In : Human Genetics. 137, 1, p. 45–53 9 p.

Research output: Contribution to journalArticle

Obesity
Health
Single Nucleotide Polymorphism
Triglycerides
Body Mass Index
5 Citations (Scopus)
Open Access
Optical Coherence Tomography
Smooth Muscle
smooth muscle
tomography
optics
2 Citations (Scopus)

Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling

Wang, J., Faiz, A., Ge, Q., Vermeulen, C. J., Van der Velden, J., Snibson, K. J., van de Velde, R., Sawant, S., Xenaki, D., Oliver, B., Timens, W., ten Hacken, N., van den Berge, M., James, A., Elliot, J. G., Dong, L., Burgess, J. K. & Ashton, A. W., 1 May 2018, In : Journal of Cellular and Molecular Medicine. 22, 5, p. 2826-2837 12 p.

Research output: Contribution to journalArticle

Open Access
Connective Tissue Growth Factor
Airway Remodeling
Smooth Muscle
Asthma
Smooth Muscle Myocytes
12 Citations (Scopus)
84 Downloads (Pure)
Open Access
File
Asthma
Lung
Flow patterns
Muscle
Smooth Muscle
4 Citations (Scopus)
Vitamin D
Health
Social Adjustment
Bronchitis
Spirometry
2017
4 Citations (Scopus)

Airway remodeling in asthma: Is it fixed or variable?

James, A., 15 Apr 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 8, p. 968-970 3 p.

Research output: Contribution to journalEditorial

2 Citations (Scopus)
207 Downloads (Pure)

Assessment of the depression, anxiety, and stress scale (DASS-21) in untreated obstructive sleep apnea (OSA)

Nanthakumar, S., Bucks, R. S., Skinner, T. C., Starkstein, S., Hillman, D., James, A. & Hunter, M., 1 Oct 2017, In : Psychological Assessment. 29, 10, p. 1201-1209 9 p.

Research output: Contribution to journalArticle

Open Access
File
Obstructive Sleep Apnea
Anxiety
Depression
Sleep Apnea Syndromes
Economic Inflation
2 Citations (Scopus)

Atopy in people aged 40 years and over: Relation to airflow limitation

Guevara-Rattray, E. M., Garden, F. L., James, A. L., Wood-Baker, R., Abramson, M. J., Johns, D. P., Sonia Buist, A., Burney, P. G. J., Haydn Walters, E., Toelle, B. G. & Marks, G. B., 1 Dec 2017, In : Clinical and Experimental Allergy. 47, 12, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

Bronchodilator Agents
Asthma
Confidence Intervals
Population
Lung

Azithromycin reduces exacerbations in adults with persistent symptomatic eosinophilic asthma

Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M., Powell, H. & Simpson, J. L., Mar 2017, In : Respirology. 22, p. 24-24 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

BODY MASS INDEX AND ADIPOSE TISSUE WITHIN THE AIRWAY WALL

Elliot, J. G., Green, F. H. Y., Noble, P. B. & James, A. L., Mar 2017, In : Respirology. 22, p. 102-102 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

16 Citations (Scopus)

Cohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)

Matheson, M. C., Abramson, M. J., Allen, K., Benke, G., Burgess, J. A., Dowty, J. G., Erbas, B., Feather, I. H., Frith, P. A., Giles, G. G., Gurrin, L. C., Hamilton, G. S., Hopper, J. L., James, A. L., Jenkins, M. A., Johns, D. P., Lodge, C. J., Lowe, A. J., Markos, J., Morrison, S. C. & 8 othersPerret, J. L., Southey, M. C., Thomas, P. S., Thompson, B. R., Wood-Baker, R., Walters, E. H., Dharmage, S. C. & TAHS investigator group, Apr 2017, In : International Journal of Epidemiology. 46, 2, p. 407-408i 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
172 Downloads (Pure)
Open Access
File
Bone Density
Body Mass Index
Fats
Adipose Tissue
Body Composition
120 Citations (Scopus)

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial

Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M., Powell, H., Taylor, S. L., Leong, L. E. X., Rogers, G. B. & Simpson, J. L., 12 Aug 2017, In : The Lancet. 390, 10095, p. 659-668 10 p.

Research output: Contribution to journalArticle

Azithromycin
Asthma
Placebos
Quality of Life
Bronchodilator Agents
9 Citations (Scopus)

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Aschard, H., Tobin, M. D., Hancock, D. B., Skurnik, D., Sood, A., James, A., Smith, A. V., Manichaikul, A. W., Campbell, A., Prins, B. P., Hayward, C., Loth, D. W., Porteous, D. J., Strachan, D. P., Zeggini, E., O'Connor, G. T., Brusselle, G. G., Boezen, H. M., Schulz, H., Deary, I. J. & 31 othersHall, I. P., Rudan, I., Kaprio, J., Wilson, J. F., Wilk, J. B., Huffman, J. E., Zhao, J. H., de Jong, K., Lyytikäinen, L. P., Wain, L. V., Jarvelin, M. R., Kähönen, M., Fornage, M., Polasek, O., Cassano, P. A., Barr, R. G., Rawal, R., Harris, S. E., Gharib, S. A., Enroth, S., Heckbert, S. R., Lehtimäki, T., Gyllensten, U., Jackson, V. E., Gudnason, V., Tang, W., Dupuis, J., Artigas, M. S., Joshi, A. D., London, S. J. & Kraft, P., 1 Jun 2017, In : International Journal of Epidemiology. 46, 3, p. 894-904 11 p., dyw318.

Research output: Contribution to journalArticle

Open Access
Forced Expiratory Volume
Smoking
Lung
Genes
Single Nucleotide Polymorphism
24 Citations (Scopus)
223 Downloads (Pure)

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

Ferreira, M. A. R., Jansen, R., Willemsen, G., Penninx, B. W., Bain, L. M., Vicente, C. T., Revez, J. A., Matheson, M. C., Hui, J., Tung, J. Y., Baltic, S., Le Souëf, P., Montgomery, G. W., Martin, N. G., Robertson, C. F., James, A., Thompson, P. J., Boomsma, D. I., Hopper, J. L., Hinds, D. A. & 3 othersWerder, R. B., Phipps, S. & Australian Asthma Genetics Consortium Collaborators, 1 Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1148-1157 10 p.

Research output: Contribution to journalArticle

Open Access
File
Quantitative Trait Loci
Asthma
Nucleotides
Genome-Wide Association Study
Genes
7 Citations (Scopus)

Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline

John, C., Artigas, M. S., Hui, J., Nielsen, S. F., Rafaels, N., Pare, P. D., Hansel, N. N., Shrine, N., Kilty, I., Malarstig, A., Jelinsky, S. A., Vedel-Krogh, S., Barnes, K., Hall, I. P., Beilby, J., Musk, A., Nordestgaard, B. G., James, A., Wain, L. V. & Tobin, M. D., May 2017, In : Thorax. 72, 5, p. 400-408 9 p.

Research output: Contribution to journalArticle

Open Access

Genetic variants in HLA are a significant risk factor for peanut allergy independent of asthma

Asai, Y., Al-Eslami, A., Akhabir, L., Ben-Shoshan, M., Sandford, A., Chin, R., Cheuk, S. T., Hui, J., Musk, W. B., Hunter, M., James, A., Clarke, A. E. & Daley, D., Feb 2017, In : The Journal of Allergy and Clinical Immunology. 139, 2, p. AB88-AB88 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

82 Citations (Scopus)

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Wain, L. V., Shrine, N., Artigas, M. S., Erzurumluoglu, A. M., Noyvert, B., Bossini-Castillo, L., Obeidat, ME., Henry, A. P., Portelli, M. A., Hall, R. J., Billington, C. K., Rimington, T. L., Fenech, A. G., John, C., Blake, T., Jackson, V. E., Allen, R. J., Prins, B. P., Campbell, A., Porteous, D. J. & 86 othersJarvelin, M. R., Wielscher, M., James, A. L., Hui, J., Wareham, N. J., Zhao, J. H., Wilson, J. F., Joshi, P. K., Stubbe, B., Rawal, R., Schulz, H., Imboden, M., Probst-Hensch, N. M., Karrasch, S., Gieger, C., Deary, I. J., Harris, S. E., Marten, J., Rudan, I., Enroth, S., Gyllensten, U., Kerr, S. M., Polasek, O., Kähönen, M., Surakka, I., Vitart, V., Hayward, C., Lehtimäki, T., Raitakari, O. T., Evans, D. M., Henderson, A. J., Pennell, C. E., Wang, C. A., Sly, P. D., Wan, E. S., Busch, R., Hobbs, B. D., Litonjua, A. A., Sparrow, D. W., Gulsvik, A., Bakke, P. S., Crapo, J. D., Beaty, T. H., Hansel, N. N., Mathias, R. A., Ruczinski, I., Barnes, K. C., Bossé, Y., Joubert, P., Van Den Berge, M., Brandsma, C. A., Paré, P. D., Sin, D. D., Nickle, D. C., Hao, K., Gottesman, O., Dewey, F. E., Bruse, S. E., Carey, D. J., Kirchner, H. L., Jonsson, S., Thorleifsson, G., Jonsdottir, I., Gislason, T., Stefansson, K., Schurmann, C., Nadkarni, G., Bottinger, E. P., Loos, R. J. F., Walters, R. G., Chen, Z., Millwood, I. Y., Vaucher, J., Kurmi, O. P., Li, L., Hansell, A. L., Brightling, C., Zeggini, E., Cho, M. H., Silverman, E. K., Sayers, I., Trynka, G., Morris, A. P., Strachan, D. P., Hall, I. P. & Tobin, M. D., 1 Mar 2017, In : Nature Genetics. 49, 3, p. 416-425 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Chronic Obstructive Pulmonary Disease
Lung
Drug Repositioning
Inositol Phosphates
142 Citations (Scopus)

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J. P., Kraja, A. T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Segura Lepe, M. P., O'Reilly, P., Knight, J., Snieder, H. & 249 othersKato, N., He, J., Shyong Tai, E., Abdullah Said, M., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., Chakravarti, A., Newton-Cheh, C., Lindgren, C. M., Levy, D., Kooner, J. S., Keavney, B. D., Tomaszewski, M., Samani, N. J., Howson, J. M. M., Tobin, M. D., Munroe, P. B., Ehret, G. B., Wain, V., Barnes, M. R., Tzoulaki, I., Caulfield, M. J., Elliott, P., Wain, V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P. J., Mesut Erzurumluoglu, A., O'Reilly, P., Rose, L. M., Verwoert, G. C., Hottenga, J. J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S. J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N., Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, J., Fabiola Del Greco, M., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Gandin, I., Harris, S. E., Zemonik, T., Lu, Y., Shah, N., de Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Batini, C., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brumat, M., Campbell, H., Cocca, M., Collins, F., Cordell, H. J., Damman, J. J., Davies, G., de Geus, E. J., de Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Ferreira, T., Frånberg, M., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Jarvelin, M. R., Johansson, Å., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Pramstaller, P. P., Raitakari, O. T., Rice, K., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Siscovick, D., Sorice, R., Stott, D. J., Sundström, J., Swertz, M., Taylor, K. D., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., John, A., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Lindgren, C. M., Vitart, V., Tuomilehto, J., Gyllensten, U., Knekt, P., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y. M., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Wouter Jukema, J., Strachan, D. P., Palmas, W., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M. & Morris, A. P., 1 Mar 2017, In : Nature Genetics. 49, 3, p. 403-415 13 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Blood Pressure
Cardiovascular Diseases
Precision Medicine
Computer Simulation
41 Citations (Scopus)

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Justice, A. E., Winkler, T. W., Feitosa, M. F., Graff, M., Fisher, V. A., Young, K., Barata, L., Deng, X., Czajkowski, J., Hadley, D., Ngwa, J. S., Ahluwalia, T. S., Chu, A. Y., Heard-Costa, N. L., Lim, E., Perez, J., Eicher, J. D., Kutalik, Z., Xue, L., Mahajan, A. & 297 othersRenström, F., Wu, J., Qi, Q., Ahmad, S., Alfred, T., Amin, N., Bielak, L. F., Bonnefond, A., Bragg, J., Cadby, G., Chittani, M., Coggeshall, S., Corre, T., Direk, N., Eriksson, J., Fischer, K., Gorski, M., Harder, M. N., Horikoshi, M., Huang, T., Huffman, J. E., Jackson, A. U., Justesen, J. M., Kanoni, S., Kinnunen, L., Kleber, M. E., Komulainen, P., Kumari, M., Lim, U., Luan, J., Lyytikäinen, L. P., Mangino, M., Manichaikul, A., Marten, J., Middelberg, R. P. S., Müller-Nurasyid, M., Navarro, P., Pe'russe, L., Pervjakova, N., Sarti, C., Smith, A. V., Smith, J. A., Stanča'kova, A., Strawbridge, R. J., Stringham, H. M., Sung, Y. J., Tanaka, T., Teumer, A., Trompet, S., Van Der Laan, S. W., Van Der Most, P. J., Van Vliet-Ostaptchouk, J. V., Vedantam, S. L., Verweij, N., Vink, J. M., Vitart, V., Wu, Y., Yengo, L., Zhang, W., Zhao, J. H., Zimmermann, M. E., Zubair, N., Abecasis, G. R., Adair, L. S., Afaq, S., Afzal, U., Bakker, S. J. L., Bartz, T. M., Beilby, J., Bergman, R. N., Bergmann, S., Biffar, R., Blangero, J., Boerwinkle, E., Bonnycastle, L. L., Bottinger, E., Braga, D., Buckley, B. M., Buyske, S., Campbell, H., Chambers, J. C., Collins, F. S., Curran, J. E., De Borst, G. J., De Craen, A. J. M., De Geus, E. J. C., Dedoussis, G., Delgado, G. E., Den Ruijter, H. M., Eiriksdottir, G., Eriksson, A. L., Esko, T., Faul, J. D., Ford, I., Forrester, T., Gertow, K., Gigante, B., Glorioso, N., Gong, J., Grallert, H., Grammer, T. B., Grarup, N., Haitjema, S., Hallmans, G., Hamsten, A., Hansen, T., Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N. D., Heath, A. C., Hernandez, D., Hindorff, L., Hocking, L. J., Hollensted, M., Holmen, O. L., Homuth, G., Hottenga, J. J., Huang, J., Hung, J., Hutri-Kähönen, N., Ingelsson, E., James, A. L., Jansson, J. O., Jarvelin, M. R., Jhun, M. A., Jorgensen, M. E., Juonala, M., Kähönen, M., Karlsson, M., Koistinen, H. A., Kolcic, I., Kolovou, G., Kooperberg, C., Krämer, B. K., Kuusisto, J., Kvaloy, K., Lakka, T. A., Langenberg, C., Launer, L. J., Leander, K., Lee, N. R., Lind, L., Lindgren, C. M., Linneberg, A., Lobbens, S., Loh, M., Lorentzon, M., Luben, R., Lubke, G., Ludolph-Donislawski, A., Lupoli, S., Madden, P. A. F., Männikkö, R., Marques-Vidal, P., Martin, N. G., McKenzie, C. A., McKnight, B., Mellström, D., Menni, C., Montgomery, G. W., Musk, A. W., Narisu, N., Nauck, M., Nolte, I. M., Oldehinkel, A. J., Olden, M., Ong, K. K., Padmanabhan, S., Peyser, P. A., Pisinger, C., Porteous, D. J., Raitakari, O. T., Rankinen, T., Rao, D. C., Rasmussen-Torvik, L. J., Rawal, R., Rice, T., Ridker, P. M., Rose, L. M., Bien, S. A., Rudan, I., Sanna, S., Sarzynski, M. A., Sattar, N., Savonen, K., Schlessinger, D., Scholtens, S., Schurmann, C., Scott, R. A., Sennblad, B., Siemelink, M. A., Silbernagel, G., Slagboom, P. E., Snieder, H., Staessen, J. A., Stott, D. J., Swertz, M. A., Swift, A. J., Taylor, K. D., Tayo, B. O., Thorand, B., Thuillier, D., Tuomilehto, J., Uitterlinden, A. G., Vandenput, L., Vohl, M. C., Völzke, H., Vonk, J. M., Waeber, G., Waldenberger, M., Westendorp, R. G. J., Wild, S., Willemsen, G., Wolffenbuttel, B. H. R., Wong, A., Wright, A. F., Zhao, W., Zillikens, M. C., Baldassarre, D., Balkau, B., Bandinelli, S., Böger, C. A., Boomsma, D. I., Bouchard, C., Bruinenberg, M., Chasman, D. I., Ida Chen, Y. D., Chines, P. S., Cooper, R. S., Cucca, F., Cusi, D., De Faire, U., Ferrucci, L., Franks, P. W., Froguel, P., Gordon-Larsen, P., Grabe, H. J., Gudnason, V., Haiman, C. A., Hayward, C., Hveem, K., Johnson, A. D., Jukema, J. W., Kardia, S. L. R., Kivimaki, M., Kooner, J. S., Kuh, D., Laakso, M., Lehtimäki, T., Le Marchand, L., März, W., McCarthy, M. I., Metspalu, A., Morris, A. P., Ohlsson, C., Palmer, L. J., Pasterkamp, G., Pedersen, O., Peters, A., Peters, U., Polasek, O., Psaty, B. M., Qi, L., Rauramaa, R., Smith, B. H., Sorensen, T. I. A., Strauch, K., Tiemeier, H., Tremoli, E., Van Der Harst, P., Vestergaard, H., Vollenweider, P., Wareham, N. J., Weir, D. R., Whitfield, J. B., Wilson, J. F., Tyrrell, J., Frayling, T. M., Barroso, I., Boehnke, M., Deloukas, P., Fox, C. S., Hirschhorn, J. N., Hunter, D. J., Spector, T. D., Strachan, D. P., Van Duijn, C. M., Heid, I. M., Mohlke, K. L., Marchini, J., Loos, R. J. F., Kilpeläinen, T. O., Liu, C. T., Borecki, I. B., North, K. E. & Cupples, L. A., 26 Apr 2017, In : Nature Communications. 8, 14977.

Research output: Contribution to journalArticle

Open Access
obesity
genome
loci
Meta-Analysis
Obesity
51 Citations (Scopus)
141 Downloads (Pure)

Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N. L., den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renström, F., Quaye, L., Eicher, J. D. & 233 othersHayes, J. E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J. E., Zhang, W., Zhao, W., Griffin, P. J., Haller, T., Ahmad, S., Marques-Vidal, P. M., Bien, S., Yengo, L., Teumer, A., Smith, A. V., Kumari, M., Harder, M. N., Justesen, J. M., Kleber, M. E., Hollensted, M., Lohman, K., Rivera, N. V., Whitfield, J. B., Zhao, J. H., Stringham, H. M., Lyytikäinen, L. P., Huppertz, C., Willemsen, G., Peyrot, W. J., Wu, Y., Kristiansson, K., Demirkan, A., Fornage, M., Hassinen, M., Bielak, L. F., Cadby, G., Tanaka, T., Mägi, R., Van Der Most, P. J., Jackson, A. U., Bragg-Gresham, J. L., Vitart, V., Marten, J., Navarro, P., Bellis, C., Pasko, D., Johansson, Å., Snitker, S., Cheng, C. Y., Eriksson, J., Lim, U., Aadahl, M., Adair, L. S., Amin, N., Balkau, B., Auvinen, J., Beilby, J., Bergman, R. N., Bergmann, S., Bertoni, A. G., Blangero, J., Bonnefond, A., Bonnycastle, L. L., Borja, J. B., Brage, S., Busonero, F., Buyske, S., Campbell, H., Chines, P. S., Collins, F. S., Corre, T., Smith, G. D., Delgado, G. E., Dueker, N., Dörr, M., Ebeling, T., Eiriksdottir, G., Esko, T., Faul, J. D., Fu, M., Færch, K., Gieger, C., Gläser, S., Gong, J., Gordon-Larsen, P., Grallert, H., Grammer, T. B., Grarup, N., van Grootheest, G., Harald, K., Hastie, N. D., Havulinna, A. S., Hernandez, D. G., Hindorff, L., Hocking, L. J., Holmens, O. L., Holzapfel, C., Hottenga, J. J., Huang, J., Huang, T., Hui, J., Huth, C., Hutri-Kähönen, N., James, A. L., Jansson, J. O., Jhun, M. A., Juonala, M., Kinnunen, L., Koistinen, H. A., Kolcic, I., Komulainen, P., Kuusisto, J., Kvaløy, K., Kähönen, M., Lakka, T. A., Launer, L. J., Lehne, B., Lindgren, C. M., Lorentzon, M., Luben, R. N., Marre, M., Milaneschi, Y., Monda, K. L., Montgomery, G. W., De Moor, M. H. M., Mulas, A., Müller-Nurasyid, M., Musk, A. W., Männikkö, R., Männistö, S., Narisu, N., Nauck, M., Nettleton, J. A., Nolte, I. M., Oldehinkel, A. J., Olden, M., Ong, K. K., Padmanabhan, S., Paternoster, L., Perez, J., Perola, M., Peters, A., Peters, U., Peyser, P. A., Prokopenko, I., Puolijoki, H., Raitakari, O. T., Rankinen, T., Rasmussen-Torvik, L. J., Rawal, R., Ridker, P. M., Rose, L. M., Rudan, I., Sarti, C., Sarzynski, M. A., Savonen, K., Scott, W. R., Sanna, S., Shuldiner, A. R., Sidney, S., Silbernagel, G., Smith, B. H., Smith, J. A., Snieder, H., Stančáková, A., Sternfeld, B., Swift, A. J., Tammelin, T., Tan, S. T., Thorand, B., Thuillier, D., Vandenput, L., Vestergaard, H., Van Vliet-Ostaptchouk, J. V., Vohl, M. C., Völker, U., Waeber, G., Walker, M., Wild, S. H., Wong, A., Wright, A. F., Zillikens, M. C., Zubair, N., Haiman, C. A., Lemarchand, L., Gyllensten, U., Ohlsson, C., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Pérusse, L., Wilson, J. F., Hayward, C., Polasek, O., Cucca, F., Hveem, K., Hartman, C. A., Tönjes, A., Bandinelli, S., Palmer, L. J., Kardia, S. L. R., Rauramaa, R., Sørensen, T. I. A., Tuomilehto, J., Salomaa, V., Penninx, B. W. J. H., De Geus, E. J. C. N., Boomsma, D. I., Lehtimäki, T., Mangino, M., Laakso, M., Bouchard, C., Martin, N. G., Kuh, D., Liu, Y., Linneberg, A., März, W., Strauch, K., Kivimäki, M., Harris, T. B., Gudnason, V., Völzke, H., Qi, L., Järvelin, M. R., Chambers, J. C., Kooner, J. S., Froguel, P., Kooperberg, C., Vollenweider, P., CHARGE consortium, EPIC-InterAct Consortium & PAGE Consortium, 1 Apr 2017, In : PLoS Genetics. 13, 4, e1006528.

Research output: Contribution to journalArticle

Open Access
physical activity
Adiposity
meta-analysis
adiposity
Meta-Analysis
8 Citations (Scopus)

Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restriction

Wang, K. C. W., Morton, J. S., Davidge, S. T., Larcombe, A. N., James, A. L., Donovan, G. M. & Noble, P. B., 17 May 2017, In : Respirology. 22, 7, p. 1-7 7 p.

Research output: Contribution to journalArticle

Growth
Lung
Bronchoconstriction
Bronchoalveolar Lavage Fluid
Macrophages
4 Citations (Scopus)

Mannitol challenge testing for asthma in a community cohort of young adults

White, E. C., de Klerk, N., Hantos, Z., Priston, M., Hollams, E. M., James, A., Sly, P. D., Holt, P. G. & Hall, G. L., 1 May 2017, In : Respirology. 22, 4, p. 678-683 6 p.

Research output: Contribution to journalArticle

Mannitol
Young Adult
Asthma
Respiratory Sounds
Population
10 Citations (Scopus)

Myofibroblasts are increased in the lung parenchyma in asthma

Boser, S. R., Mauad, T., de Araujo-Paulino, B. B., Mitchell, I., Shrestha, G., Chiu, A., Butt, J., Kelly, M. M., Caldini, E., James, A. & Green, F., 7 Aug 2017, In : PLoS One. 12, 8, 14 p., e0182378.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney

Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., Van Der Most, P. J., Erzurumluoglu, A. M., O'Reilly, P. F., Cabrera, C. P., Warren, H. R., Rose, L. M., Verwoert, G. C., Hottenga, J. J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S. J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N. & 223 othersTeumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, JA., Del Greco, F. M., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Marten, J., Gandin, I., Harris, S. E., Zemunik, T., Lu, Y., Evangelou, E., Shah, N., De Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Barnes, M. R., Batini, C., Beilby, J., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brown, M. J., Brumat, M., Campbell, H., Chambers, J. C., Cocca, M., Collins, F. S., Connell, J., Cordell, H. J., Damman, J. J., Davies, G., De Geus, E. J. C. N., De Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Farrall, M., Ferreira, T., Frånberg, M., Gao, H., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Hui, J., Jarvelin, M. R., Johansson, Å., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Mifsud, B., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Padmanabhan, S., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Poulter, N., Pramstaller, P. P., Raitakari, O. T., Ren, M., Rice, K. M., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint-Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Shields, D. C., Siscovick, D. S., Sorice, R., Stanton, A., Stott, D. J., Sundström, J., Swertz, M. A., Taylor, K. D., Thom, S., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S. H., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., Attia, J., Sever, P., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., Van der Harst, P., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Hayward, C., Kooner, J. S., Lindgren, C. M., Vitart, V., Samani, N. J., Tuomilehto, J., Gyllensten, U., Knekt, P. B., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Jukema, J. W., Strachan, D. P., Palmas, W., Metspalu, A., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M., Newton-Cheh, C., Munroe, P. B., Elliott, P., Chasman, D. I., Chakravarti, A., Knight, J., Morris, A. P., Levy, D., Tobin, M. D., Snieder, H., Caulfield, M. J. & Ehret, G. B., 1 Sep 2017, In : Hypertension. 70, 3, p. e4-e19

Research output: Contribution to journalArticle

Genome-Wide Association Study
Genetic Association Studies
Blood Pressure
Kidney
Genes