Alan James

Clinical Professor

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Crawley

    Australia

  • 5920 Citations
  • 34 h-Index
20042018

Research Output 2004 2018

2018
1 Citations

Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma

Asai, Y. , Eslami, A. , van Ginkel, C. D. , Akhabir, L. , Wan, M. , Yin, D. , Ellis, G. , Ben-Shoshan, M. , Marenholz, I. , Martino, D. , Ferreira, M. A. , Allen, K. , Mazer, B. , de Groot, H. , de Jong, N. W. , Gerth van Wijk, R. , Dubois, A. E. J. , Grosche, S. , Ashley, S. , Rüschendorf, F. & 20 others Kalb, B., Beyer, K., Nöthen, M. M., Lee, Y-A., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J. S., Melles, R. B., Hong, X., Wang, X., Hui, J., Musk, A. W. B., Hunter, M., James, A. L., Koppelman, G. H., Sandford, A. J., Clarke, A. E. & Daley, D. 1 Apr 2018 In : The Journal of Allergy and Clinical Immunology. 141, 4, p. 1513-1516

Research output: Contribution to journalLetter

Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner

Wang, K. C., Larcombe, A. N., Berry, L. J., Morton, J. S., Davidge, S. T., James, A. L. & Noble, P. B. 25 Jan 2018 In : Clinical Science. 132, 2, p. 273-284

Research output: Contribution to journalArticle

Fetal Development
Growth
Asthma
Lung
Pregnancy
1 Citations

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Asai, Y. , Eslami, A. , van Ginkel, C. D. , Akhabir, L. , Wan, M. , Ellis, G. , Ben-Shoshan, M. , Martino, D. , Ferreira, M. A. , Allen, K. , Mazer, B. , de Groot, H. , de Jong, N. W. , Gerth van Wijk, R. N. , Dubois, A. E. J. , Chin, R. , Cheuk, S. , Hoffman, J. , Jorgensen, E. , Witte, J. S. & 11 others Melles, R. B., Hong, X., Wang, X., Hui, J., Musk, A. W., Hunter, M., James, A. L., Koppelman, G. H., Sandford, A. J., Clarke, A. E. & Daley, D. Mar 2018 In : Journal of Allergy and Clinical Immunology. 141, 3, p. 991-1001

Research output: Contribution to journalArticle

Open Access
Peanut Hypersensitivity
Food Hypersensitivity
Genome-Wide Association Study
Meta-Analysis
Single Nucleotide Polymorphism

Independent and combined effects of airway remodelling and allergy on airway responsiveness

Wang, K. C., Le Cras, T. D., Larcombe, A. N., Zosky, G. R., Elliot, J. G., James, A. L. & Noble, P. B. 14 Feb 2018 In : Clinical Science. 132, 3, p. 327-338 CS20171386

Research output: Contribution to journalArticle

Airway Remodeling
Hypersensitivity
Ovalbumin
Smooth Muscle
Doxycycline
7 Citations

Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology

Taylor, S. L., Leong, L. E. X., Choo, J. M., Wesselingh, S., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Baraket, M., Marks, G. B., Gibson, P. G., Simpson, J. L. & Rogers, G. B. 1 Jan 2018 In : Journal of Allergy and Clinical Immunology. 141, 1, p. 94-103.e15

Research output: Contribution to journalArticle

Open Access
Microbiology
Microbiota
Asthma
Phenotype
Sputum
1 Citations

Pathophysiology of severe asthma: We've only just started

King, G. G., James, A., Harkness, L. & Wark, P. A. B. Mar 2018 In : Respirology. 23, 3, p. 262-271

Research output: Contribution to journalReview article

Asthma
Health Services
Therapeutics
Clinical Studies
1 Citations

Pleiotropy of cardiometabolic syndrome with obesity-related anthropometric traits determined using empirically derived kinships from the Busselton Health Study

Cadby, G., Melton, P. E., McCarthy, N. S., Almeida, M., Williams-Blangero, S., Curran, J. E., VandeBerg, J. L., Hui, J., Beilby, J., Musk, A. W., James, A. L., Hung, J., Blangero, J. & Moses, E. K. 2018 In : Human Genetics. 137, 1, p. 45–53 9 p.

Research output: Contribution to journalArticle

Obesity
Health
Waist-Hip Ratio
Single Nucleotide Polymorphism
Triglycerides
Vitamin D
Bronchitis
Health
Thorax
Asthma
2017
1 Citations

Airway remodeling in asthma: Is it fixed or variable?

James, A. 15 Apr 2017 In : American Journal of Respiratory and Critical Care Medicine. 195, 8, p. 968-970 3 p.

Research output: Contribution to journalEditorial

Assessment of the depression, anxiety, and stress scale (DASS-21) in untreated obstructive sleep apnea (OSA)

Nanthakumar, S., Bucks, R. S., Skinner, T. C., Starkstein, S., Hillman, D., James, A. & Hunter, M. 1 Oct 2017 In : Psychological Assessment. 29, 10, p. 1201-1209 9 p.

Research output: Contribution to journalArticle

Obstructive Sleep Apnea
Anxiety
Depression
Sleep Apnea Syndromes
Economic Inflation

Atopy in people aged 40 years and over: Relation to airflow limitation

Guevara-Rattray, E. M., Garden, F. L., James, A. L., Wood-Baker, R., Abramson, M. J., Johns, D. P., Sonia Buist, A., Burney, P. G. J., Haydn Walters, E., Toelle, B. G. & Marks, G. B. 1 Dec 2017 In : Clinical and Experimental Allergy. 47, 12, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

Bronchodilator Agents
Asthma
Confidence Intervals
Population
Lung

Azithromycin reduces exacerbations in adults with persistent symptomatic eosinophilic asthma

Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M., Powell, H. & Simpson, J. L. Mar 2017 In : Respirology. 22, p. 24-24 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

BODY MASS INDEX AND ADIPOSE TISSUE WITHIN THE AIRWAY WALL

Elliot, J. G., Green, F. H. Y., Noble, P. B. & James, A. L. Mar 2017 In : Respirology. 22, p. 102-102 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Cohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)

Matheson, M. C. , Abramson, M. J. , Allen, K. , Benke, G. , Burgess, J. A. , Dowty, J. G. , Erbas, B. , Feather, I. H. , Frith, P. A. , Giles, G. G. , Gurrin, L. C. , Hamilton, G. S. , Hopper, J. L. , James, A. L. , Jenkins, M. A. , Johns, D. P. , Lodge, C. J. , Lowe, A. J. , Markos, J. , Morrison, S. C. & 8 others Perret, J. L., Southey, M. C., Thomas, P. S., Thompson, B. R., Wood-Baker, R., Walters, E. H., Dharmage, S. C. & TAHS investigator group Apr 2017 In : International Journal of Epidemiology. 46, 2, p. 407-408i 11 p.

Research output: Contribution to journalArticle

2 Citations
Open Access
File
Bone Density
Body Mass Index
Fats
Adipose Tissue
Body Composition
33 Citations

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial

Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A. L., Jenkins, C., Peters, M. J., Marks, G. B., Baraket, M., Powell, H., Taylor, S. L., Leong, L. E. X., Rogers, G. B. & Simpson, J. L. 12 Aug 2017 In : The Lancet. 390, 10095, p. 659-668 10 p.

Research output: Contribution to journalArticle

Azithromycin
Asthma
Placebos
Quality of Life
Bronchodilator Agents

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Aschard, H. , Tobin, M. D. , Hancock, D. B. , Skurnik, D. , Sood, A. , James, A. , Smith, A. V. , Manichaikul, A. W. , Campbell, A. , Prins, B. P. , Hayward, C. , Loth, D. W. , Porteous, D. J. , Strachan, D. P. , Zeggini, E. , O'Connor, G. T. , Brusselle, G. G. , Boezen, H. M. , Schulz, H. , Deary, I. J. & 31 others Hall, I. P., Rudan, I., Kaprio, J., Wilson, J. F., Wilk, J. B., Huffman, J. E., Zhao, J. H., de Jong, K., Lyytikäinen, L. P., Wain, L. V., Jarvelin, M. R., Kähönen, M., Fornage, M., Polasek, O., Cassano, P. A., Barr, R. G., Rawal, R., Harris, S. E., Gharib, S. A., Enroth, S., Heckbert, S. R., Lehtimäki, T., Gyllensten, U., Jackson, V. E., Gudnason, V., Tang, W., Dupuis, J., Artigas, M. S., Joshi, A. D., London, S. J. & Kraft, P. 1 Jun 2017 In : International Journal of Epidemiology. 46, 3, p. 894-904 11 p., dyw318

Research output: Contribution to journalArticle

Smoking
Lung
Genes
Single Nucleotide Polymorphism
Accidental Falls
8 Citations

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

Ferreira, M. A. R. , Jansen, R. , Willemsen, G. , Penninx, B. W. , Bain, L. M. , Vicente, C. T. , Revez, J. A. , Matheson, M. C. , Hui, J. , Tung, J. Y. , Baltic, S. , Le Souëf, P. , Montgomery, G. W. , Martin, N. G. , Robertson, C. F. , James, A. , Thompson, P. J. , Boomsma, D. I. , Hopper, J. L. , Hinds, D. A. & 3 others Werder, R. B., Phipps, S. & Australian Asthma Genetics Consortium Collaborators 1 Apr 2017 In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1148-1157 10 p.

Research output: Contribution to journalArticle

Open Access
File
Quantitative Trait Loci
Asthma
Nucleotides
Genome-Wide Association Study
Genes

Genetic variants in HLA are a significant risk factor for peanut allergy independent of asthma

Asai, Y., Al-Eslami, A., Akhabir, L., Ben-Shoshan, M., Sandford, A., Chin, R., Cheuk, S. T., Hui, J., Musk, W. . B., Hunter, M., James, A., Clarke, A. E. & Daley, D. Feb 2017 In : The Journal of Allergy and Clinical Immunology. 139, 2, p. AB88-AB88 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

22 Citations

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Wain, L. V. , Shrine, N. , Artigas, M. S. , Erzurumluoglu, A. M. , Noyvert, B. , Bossini-Castillo, L. , Obeidat, M. E. , Henry, A. P. , Portelli, M. A. , Hall, R. J. , Billington, C. K. , Rimington, T. L. , Fenech, A. G. , John, C. , Blake, T. , Jackson, V. E. , Allen, R. J. , Prins, B. P. , Campbell, A. , Porteous, D. J. & 86 others Jarvelin, M. R., Wielscher, M., James, A. L., Hui, J., Wareham, N. J., Zhao, J. H., Wilson, J. F., Joshi, P. K., Stubbe, B., Rawal, R., Schulz, H., Imboden, M., Probst-Hensch, N. M., Karrasch, S., Gieger, C., Deary, I. J., Harris, S. E., Marten, J., Rudan, I., Enroth, S., Gyllensten, U., Kerr, S. M., Polasek, O., Kähönen, M., Surakka, I., Vitart, V., Hayward, C., Lehtimäki, T., Raitakari, O. T., Evans, D. M., Henderson, A. J., Pennell, C. E., Wang, C. A., Sly, P. D., Wan, E. S., Busch, R., Hobbs, B. D., Litonjua, A. A., Sparrow, D. W., Gulsvik, A., Bakke, P. S., Crapo, J. D., Beaty, T. H., Hansel, N. N., Mathias, R. A., Ruczinski, I., Barnes, K. C., Bossé, Y., Joubert, P., Van Den Berge, M., Brandsma, C. A., Paré, P. D., Sin, D. D., Nickle, D. C., Hao, K., Gottesman, O., Dewey, F. E., Bruse, S. E., Carey, D. J., Kirchner, H. L., Jonsson, S., Thorleifsson, G., Jonsdottir, I., Gislason, T., Stefansson, K., Schurmann, C., Nadkarni, G., Bottinger, E. P., Loos, R. J. F., Walters, R. G., Chen, Z., Millwood, I. Y., Vaucher, J., Kurmi, O. P., Li, L., Hansell, A. L., Brightling, C., Zeggini, E., Cho, M. H., Silverman, E. K., Sayers, I., Trynka, G., Morris, A. P., Strachan, D. P., Hall, I. P. & Tobin, M. D. 1 Mar 2017 In : Nature Genetics. 49, 3, p. 416-425 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Chronic Obstructive Pulmonary Disease
Lung
Drug Repositioning
Inositol Phosphates
51 Citations

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Warren, H. R. , Evangelou, E. , Cabrera, C. P. , Gao, H. , Ren, M. , Mifsud, B. , Ntalla, I. , Surendran, P. , Liu, C. , Cook, J. P. , Kraja, A. T. , Drenos, F. , Loh, M. , Verweij, N. , Marten, J. , Karaman, I. , Segura Lepe, M. P. , O'Reilly, P. , Knight, J. , Snieder, H. & 249 others Kato, N., He, J., Shyong Tai, E., Abdullah Said, M., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., Chakravarti, A., Newton-Cheh, C., Lindgren, C. M., Levy, D., Kooner, J. S., Keavney, B. D., Tomaszewski, M., Samani, N. J., Howson, J. M. M., Tobin, M. D., Munroe, P. B., Ehret, G. B., Wain, V., Barnes, M. R., Tzoulaki, I., Caulfield, M. J., Elliott, P., Wain, V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P. J., Mesut Erzurumluoglu, A., O'Reilly, P., Rose, L. M., Verwoert, G. C., Hottenga, J. J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S. J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N., Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, J., Fabiola Del Greco, M., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Gandin, I., Harris, S. E., Zemonik, T., Lu, Y., Shah, N., de Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Batini, C., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brumat, M., Campbell, H., Cocca, M., Collins, F., Cordell, H. J., Damman, J. J., Davies, G., de Geus, E. J., de Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Ferreira, T., Frånberg, M., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Jarvelin, M. R., Johansson, Å., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Pramstaller, P. P., Raitakari, O. T., Rice, K., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Siscovick, D., Sorice, R., Stott, D. J., Sundström, J., Swertz, M., Taylor, K. D., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., John, A., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Lindgren, C. M., Vitart, V., Tuomilehto, J., Gyllensten, U., Knekt, P., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y. M., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Wouter Jukema, J., Strachan, D. P., Palmas, W., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M. & Morris, A. P. 1 Mar 2017 In : Nature Genetics. 49, 3, p. 403-415 13 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Blood Pressure
Cardiovascular Diseases
Precision Medicine
Computer Simulation
16 Citations

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Justice, A. E. , Winkler, T. W. , Feitosa, M. F. , Graff, M. , Fisher, V. A. , Young, K. , Barata, L. , Deng, X. , Czajkowski, J. , Hadley, D. , Ngwa, J. S. , Ahluwalia, T. S. , Chu, A. Y. , Heard-Costa, N. L. , Lim, E. , Perez, J. , Eicher, J. D. , Kutalik, Z. , Xue, L. , Mahajan, A. & 297 others Renström, F., Wu, J., Qi, Q., Ahmad, S., Alfred, T., Amin, N., Bielak, L. F., Bonnefond, A., Bragg, J., Cadby, G., Chittani, M., Coggeshall, S., Corre, T., Direk, N., Eriksson, J., Fischer, K., Gorski, M., Harder, M. N., Horikoshi, M., Huang, T., Huffman, J. E., Jackson, A. U., Justesen, J. M., Kanoni, S., Kinnunen, L., Kleber, M. E., Komulainen, P., Kumari, M., Lim, U., Luan, J., Lyytikäinen, L. P., Mangino, M., Manichaikul, A., Marten, J., Middelberg, R. P. S., Müller-Nurasyid, M., Navarro, P., Pe'russe, L., Pervjakova, N., Sarti, C., Smith, A. V., Smith, J. A., Stanča'kova, A., Strawbridge, R. J., Stringham, H. M., Sung, Y. J., Tanaka, T., Teumer, A., Trompet, S., Van Der Laan, S. W., Van Der Most, P. J., Van Vliet-Ostaptchouk, J. V., Vedantam, S. L., Verweij, N., Vink, J. M., Vitart, V., Wu, Y., Yengo, L., Zhang, W., Zhao, J. H., Zimmermann, M. E., Zubair, N., Abecasis, G. R., Adair, L. S., Afaq, S., Afzal, U., Bakker, S. J. L., Bartz, T. M., Beilby, J., Bergman, R. N., Bergmann, S., Biffar, R., Blangero, J., Boerwinkle, E., Bonnycastle, L. L., Bottinger, E., Braga, D., Buckley, B. M., Buyske, S., Campbell, H., Chambers, J. C., Collins, F. S., Curran, J. E., De Borst, G. J., De Craen, A. J. M., De Geus, E. J. C., Dedoussis, G., Delgado, G. E., Den Ruijter, H. M., Eiriksdottir, G., Eriksson, A. L., Esko, T., Faul, J. D., Ford, I., Forrester, T., Gertow, K., Gigante, B., Glorioso, N., Gong, J., Grallert, H., Grammer, T. B., Grarup, N., Haitjema, S., Hallmans, G., Hamsten, A., Hansen, T., Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N. D., Heath, A. C., Hernandez, D., Hindorff, L., Hocking, L. J., Hollensted, M., Holmen, O. L., Homuth, G., Hottenga, J. J., Huang, J., Hung, J., Hutri-Kähönen, N., Ingelsson, E., James, A. L., Jansson, J. O., Jarvelin, M. R., Jhun, M. A., Jorgensen, M. E., Juonala, M., Kähönen, M., Karlsson, M., Koistinen, H. A., Kolcic, I., Kolovou, G., Kooperberg, C., Krämer, B. K., Kuusisto, J., Kvaloy, K., Lakka, T. A., Langenberg, C., Launer, L. J., Leander, K., Lee, N. R., Lind, L., Lindgren, C. M., Linneberg, A., Lobbens, S., Loh, M., Lorentzon, M., Luben, R., Lubke, G., Ludolph-Donislawski, A., Lupoli, S., Madden, P. A. F., Männikkö, R., Marques-Vidal, P., Martin, N. G., McKenzie, C. A., McKnight, B., Mellström, D., Menni, C., Montgomery, G. W., Musk, A. W., Narisu, N., Nauck, M., Nolte, I. M., Oldehinkel, A. J., Olden, M., Ong, K. K., Padmanabhan, S., Peyser, P. A., Pisinger, C., Porteous, D. J., Raitakari, O. T., Rankinen, T., Rao, D. C., Rasmussen-Torvik, L. J., Rawal, R., Rice, T., Ridker, P. M., Rose, L. M., Bien, S. A., Rudan, I., Sanna, S., Sarzynski, M. A., Sattar, N., Savonen, K., Schlessinger, D., Scholtens, S., Schurmann, C., Scott, R. A., Sennblad, B., Siemelink, M. A., Silbernagel, G., Slagboom, P. E., Snieder, H., Staessen, J. A., Stott, D. J., Swertz, M. A., Swift, A. J., Taylor, K. D., Tayo, B. O., Thorand, B., Thuillier, D., Tuomilehto, J., Uitterlinden, A. G., Vandenput, L., Vohl, M. C., Völzke, H., Vonk, J. M., Waeber, G., Waldenberger, M., Westendorp, R. G. J., Wild, S., Willemsen, G., Wolffenbuttel, B. H. R., Wong, A., Wright, A. F., Zhao, W., Zillikens, M. C., Baldassarre, D., Balkau, B., Bandinelli, S., Böger, C. A., Boomsma, D. I., Bouchard, C., Bruinenberg, M., Chasman, D. I., Ida Chen, Y. D., Chines, P. S., Cooper, R. S., Cucca, F., Cusi, D., De Faire, U., Ferrucci, L., Franks, P. W., Froguel, P., Gordon-Larsen, P., Grabe, H. J., Gudnason, V., Haiman, C. A., Hayward, C., Hveem, K., Johnson, A. D., Jukema, J. W., Kardia, S. L. R., Kivimaki, M., Kooner, J. S., Kuh, D., Laakso, M., Lehtimäki, T., Le Marchand, L., März, W., McCarthy, M. I., Metspalu, A., Morris, A. P., Ohlsson, C., Palmer, L. J., Pasterkamp, G., Pedersen, O., Peters, A., Peters, U., Polasek, O., Psaty, B. M., Qi, L., Rauramaa, R., Smith, B. H., Sorensen, T. I. A., Strauch, K., Tiemeier, H., Tremoli, E., Van Der Harst, P., Vestergaard, H., Vollenweider, P., Wareham, N. J., Weir, D. R., Whitfield, J. B., Wilson, J. F., Tyrrell, J., Frayling, T. M., Barroso, I., Boehnke, M., Deloukas, P., Fox, C. S., Hirschhorn, J. N., Hunter, D. J., Spector, T. D., Strachan, D. P., Van Duijn, C. M., Heid, I. M., Mohlke, K. L., Marchini, J., Loos, R. J. F., Kilpeläinen, T. O., Liu, C. T., Borecki, I. B., North, K. E. & Cupples, L. A. 26 Apr 2017 In : Nature Communications. 8, 14977

Research output: Contribution to journalArticle

Open Access
obesity
genome
loci
Meta-Analysis
Obesity
18 Citations

Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Graff, M. , Scott, R. A. , Justice, A. E. , Young, K. L. , Feitosa, M. F. , Barata, L. , Winkler, T. W. , Chu, A. Y. , Mahajan, A. , Hadley, D. , Xue, L. , Workalemahu, T. , Heard-Costa, N. L. , den Hoed, M. , Ahluwalia, T. S. , Qi, Q. , Ngwa, J. S. , Renström, F. , Quaye, L. , Eicher, J. D. & 233 others Hayes, J. E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J. E., Zhang, W., Zhao, W., Griffin, P. J., Haller, T., Ahmad, S., Marques-Vidal, P. M., Bien, S., Yengo, L., Teumer, A., Smith, A. V., Kumari, M., Harder, M. N., Justesen, J. M., Kleber, M. E., Hollensted, M., Lohman, K., Rivera, N. V., Whitfield, J. B., Zhao, J. H., Stringham, H. M., Lyytikäinen, L. P., Huppertz, C., Willemsen, G., Peyrot, W. J., Wu, Y., Kristiansson, K., Demirkan, A., Fornage, M., Hassinen, M., Bielak, L. F., Cadby, G., Tanaka, T., Mägi, R., Van Der Most, P. J., Jackson, A. U., Bragg-Gresham, J. L., Vitart, V., Marten, J., Navarro, P., Bellis, C., Pasko, D., Johansson, Å., Snitker, S., Cheng, C. Y., Eriksson, J., Lim, U., Aadahl, M., Adair, L. S., Amin, N., Balkau, B., Auvinen, J., Beilby, J., Bergman, R. N., Bergmann, S., Bertoni, A. G., Blangero, J., Bonnefond, A., Bonnycastle, L. L., Borja, J. B., Brage, S., Busonero, F., Buyske, S., Campbell, H., Chines, P. S., Collins, F. S., Corre, T., Smith, G. D., Delgado, G. E., Dueker, N., Dörr, M., Ebeling, T., Eiriksdottir, G., Esko, T., Faul, J. D., Fu, M., Færch, K., Gieger, C., Gläser, S., Gong, J., Gordon-Larsen, P., Grallert, H., Grammer, T. B., Grarup, N., van Grootheest, G., Harald, K., Hastie, N. D., Havulinna, A. S., Hernandez, D. G., Hindorff, L., Hocking, L. J., Holmens, O. L., Holzapfel, C., Hottenga, J. J., Huang, J., Huang, T., Hui, J., Huth, C., Hutri-Kähönen, N., James, A. L., Jansson, J. O., Jhun, M. A., Juonala, M., Kinnunen, L., Koistinen, H. A., Kolcic, I., Komulainen, P., Kuusisto, J., Kvaløy, K., Kähönen, M., Lakka, T. A., Launer, L. J., Lehne, B., Lindgren, C. M., Lorentzon, M., Luben, R. N., Marre, M., Milaneschi, Y., Monda, K. L., Montgomery, G. W., De Moor, M. H. M., Mulas, A., Müller-Nurasyid, M., Musk, A. W., Männikkö, R., Männistö, S., Narisu, N., Nauck, M., Nettleton, J. A., Nolte, I. M., Oldehinkel, A. J., Olden, M., Ong, K. K., Padmanabhan, S., Paternoster, L., Perez, J., Perola, M., Peters, A., Peters, U., Peyser, P. A., Prokopenko, I., Puolijoki, H., Raitakari, O. T., Rankinen, T., Rasmussen-Torvik, L. J., Rawal, R., Ridker, P. M., Rose, L. M., Rudan, I., Sarti, C., Sarzynski, M. A., Savonen, K., Scott, W. R., Sanna, S., Shuldiner, A. R., Sidney, S., Silbernagel, G., Smith, B. H., Smith, J. A., Snieder, H., Stančáková, A., Sternfeld, B., Swift, A. J., Tammelin, T., Tan, S. T., Thorand, B., Thuillier, D., Vandenput, L., Vestergaard, H., Van Vliet-Ostaptchouk, J. V., Vohl, M. C., Völker, U., Waeber, G., Walker, M., Wild, S. H., Wong, A., Wright, A. F., Zillikens, M. C., Zubair, N., Haiman, C. A., Lemarchand, L., Gyllensten, U., Ohlsson, C., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Pérusse, L., Wilson, J. F., Hayward, C., Polasek, O., Cucca, F., Hveem, K., Hartman, C. A., Tönjes, A., Bandinelli, S., Palmer, L. J., Kardia, S. L. R., Rauramaa, R., Sørensen, T. I. A., Tuomilehto, J., Salomaa, V., Penninx, B. W. J. H., De Geus, E. J. C. N., Boomsma, D. I., Lehtimäki, T., Mangino, M., Laakso, M., Bouchard, C., Martin, N. G., Kuh, D., Liu, Y., Linneberg, A., März, W., Strauch, K., Kivimäki, M., Harris, T. B., Gudnason, V., Völzke, H., Qi, L., Järvelin, M. R., Chambers, J. C., Kooner, J. S., Froguel, P., Kooperberg, C., Vollenweider, P., CHARGE Consortium, EPIC-InterAct Consortium & PAGE Consortium 1 Apr 2017 In : PLoS Genetics. 13, 4, e1006528

Research output: Contribution to journalArticle

Open Access
File
physical activity
Adiposity
meta-analysis
adiposity
Meta-Analysis
4 Citations

Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restriction

Wang, K. C. W., Morton, J. S., Davidge, S. T., Larcombe, A. N., James, A. L., Donovan, G. M. & Noble, P. B. 17 May 2017 In : Respirology. 22, 7, p. 1-7 7 p.

Research output: Contribution to journalArticle

Growth
Lung
Bronchoconstriction
Bronchoalveolar Lavage Fluid
Macrophages
1 Citations

Mannitol challenge testing for asthma in a community cohort of young adults

White, E. C., de Klerk, N., Hantos, Z., Priston, M., Hollams, E. M., James, A., Sly, P. D., Holt, P. G. & Hall, G. L. 1 May 2017 In : Respirology. 22, 4, p. 678-683 6 p.

Research output: Contribution to journalArticle

Mannitol
Young Adult
Asthma
Respiratory Sounds
Population
10 Citations

Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney

Wain, L. V. , Vaez, A. , Jansen, R. , Joehanes, R. , Van Der Most, P. J. , Erzurumluoglu, A. M. , O'Reilly, P. F. , Cabrera, C. P. , Warren, H. R. , Rose, L. M. , Verwoert, G. C. , Hottenga, J. J. , Strawbridge, R. J. , Esko, T. , Arking, D. E. , Hwang, S. J. , Guo, X. , Kutalik, Z. , Trompet, S. , Shrine, N. & 223 others Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, J. A., Del Greco, F. M., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Marten, J., Gandin, I., Harris, S. E., Zemunik, T., Lu, Y., Evangelou, E., Shah, N., De Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Barnes, M. R., Batini, C., Beilby, J., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brown, M. J., Brumat, M., Campbell, H., Chambers, J. C., Cocca, M., Collins, F. S., Connell, J., Cordell, H. J., Damman, J. J., Davies, G., De Geus, E. J. C. N., De Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Farrall, M., Ferreira, T., Frånberg, M., Gao, H., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Hui, J., Jarvelin, M. R., Johansson, Å., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Mifsud, B., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Padmanabhan, S., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Poulter, N., Pramstaller, P. P., Raitakari, O. T., Ren, M., Rice, K. M., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint-Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Shields, D. C., Siscovick, D. S., Sorice, R., Stanton, A., Stott, D. J., Sundström, J., Swertz, M. A., Taylor, K. D., Thom, S., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S. H., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., Attia, J., Sever, P., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., Van der Harst, P., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Hayward, C., Kooner, J. S., Lindgren, C. M., Vitart, V., Samani, N. J., Tuomilehto, J., Gyllensten, U., Knekt, P. B., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Jukema, J. W., Strachan, D. P., Palmas, W., Metspalu, A., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M., Newton-Cheh, C., Munroe, P. B., Elliott, P., Chasman, D. I., Chakravarti, A., Knight, J., Morris, A. P., Levy, D., Tobin, M. D., Snieder, H., Caulfield, M. J. & Ehret, G. B. 1 Sep 2017 In : Hypertension. 70, 3, p. e4-e19

Research output: Contribution to journalArticle

Genome-Wide Association Study
Genetic Association Studies
Blood Pressure
Kidney
Genes
1 Citations
Open Access
Transforming Growth Factor alpha
Optical Coherence Tomography
Diaphragm
Mechanics
Lung Diseases

PREVALENCE AND COMORBIDITIES OF OBSTRUCTIVE SLEEP APNOEA IN THE BUSSELTON HEALTHY AGEING STUDY (BHAS)

Cunningham, J., James, A., Knuiman, M., Singh, B., Murray, K. & Hunter, M. Nov 2017 In : Respirology. 22, p. 72-72 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

10 Citations

Severe asthma: Current management, targeted therapies and future directions—A roundtable report

McDonald, V. M., Maltby, S., Reddel, H. K., King, G. G., Wark, P. A. B., Smith, L., Upham, J. W., James, A. L., Marks, G. B. & Gibson, P. G. 1 Jan 2017 In : Respirology. 22, 1, p. 53-60 8 p.

Research output: Contribution to journalReview article

Open Access
Asthma
Therapeutics
Respiratory Hypersensitivity
Patient Care Management
Cost of Illness

SEX DEPENDENT EFFECTS ON AIRWAY RESPONSIVENESS OF MATERNAL HYPOXIA-INDUCED INTRAUTERINE GROWTH RESTRICTED JUVENILE MICE

Wang, K. C., Larcombe, A. N., Morton, J. S., Davidge, S. T., James, A. L. & Noble, P. B. Mar 2017 In : Respirology. 22, p. 36-36 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2 Citations

Shared genetic variants suggest common pathways in allergy and autoimmune diseases

Kreiner, E. , Waage, J. , Standl, M. , Brix, S. , Pers, T. H. , Couto Alves, A. , Warrington, N. M. , Tiesler, C. M. T. , Fuertes, E. , Franke, L. , Hirschhorn, J. N. , James, A. , Simpson, A. , Tung, J. Y. , Koppelman, G. H. , Postma, D. S. , Pennell, C. E. , Jarvelin, M. R. , Custovic, A. , Timpson, N. & 6 others Ferreira, M. A., Strachan, D. P., Henderson, J., Hinds, D., Bisgaard, H. & Bønnelykke, K. 1 Sep 2017 In : Journal of Allergy and Clinical Immunology. 140, 3, p. 771-781 11 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Hypersensitivity
Single Nucleotide Polymorphism
Accidental Falls
Genetic Transcription
1 Citations

The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics

Rosner, S. R., Pascoe, C. D., Blankman, E., Jensen, C. C., Krishnan, R., James, A. L., Elliot, J. G., Green, F. H., Liu, J. C., Seow, C. Y., Park, J-A., Beckerle, M. C., Pare, P. D., Fredberg, J. J. & Smith, M. A. 9 Mar 2017 In : PLoS One. 12, 3, 16 p., 0171728

Research output: Contribution to journalArticle

Open Access

THE VOLUME FRACTION OF COLLAGEN-IV IS INCREASED WITHIN THE AIRWAY SMOOTH MUSCLE LAYER IN COPD

Elliot, J. G., Drew, S-A., Cairncross, A., Noble, P. & James, A. Mar 2017 In : TSANZ & ANZSRS Annual Scientific Meetings. 22, p. 133-133 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

2016
2 Citations

Airflow obstruction is associated with increased smooth muscle extracellular matrix

Jones, R. L., Noble, P. B., Elliot, J. G., Mitchell, H. W., McFawn, P. K., Hogg, J. C. & James, A. L. 2016 In : European Respiratory Journal. 47, 6, p. 1855-1857 3 p.

Research output: Contribution to journalArticle

34 Citations

Airway dysbiosis: Haemophilus influenza and Tropheryma in poorly controlled asthma

Simpson, J. L., Daly, J., Baines, K. J., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A., Hugenholtz, P., Willner, D. & Gibson, P. G. 2016 In : European Respiratory Journal. 47, 3, p. 792-800 9 p.

Research output: Contribution to journalArticle

Open Access
Tropheryma
Dysbiosis
Haemophilus influenzae
Asthma
Sputum
10 Citations

Airway remodelling in COPD: It's not asthma!

Jones, R. L., Noble, P. B., Elliot, J. G. & James, A. L. 1 Nov 2016 In : Respirology. 21, 8, p. 1347-1356 10 p.

Research output: Contribution to journalReview article

Airway Remodeling
Chronic Obstructive Pulmonary Disease
Asthma
Smooth Muscle
Extracellular Matrix
12 Citations

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Ried, J. S. , Jeff, J. M. , Chu, A. Y. , Bragg-Gresham, J. L. , Van Dongen, J. , Huffman, J. E. , Ahluwalia, T. S. , Cadby, G. , Eklund, N. , Eriksson, J. , Esko, T. , Feitosa, M. F. , Goel, A. , Gorski, M. , Hayward, C. , Heard-Costa, N. L. , Jackson, A. U. , Jokinen, E. , Kanoni, S. , Kristiansson, K. & 256 others Kutalik, Z., Lahti, J., Luan, J. A., Mägi, R., Mahajan, A., Mangino, M., Medina-Gomez, C., Monda, K. L., Nolte, I. M., Pérusse, L., Prokopenko, I., Qi, L., Rose, L. M., Salvi, E., Smith, M. T., Snieder, H., Standáková, A., Ju Sung, Y., Tachmazidou, I., Teumer, A., Thorleifsson, G., Van Der Harst, P., Walker, R. W., Wang, S. R., Wild, S. H., Willems, S. M., Wong, A., Zhang, W., Albrecht, E., Couto Alves, A., Bakker, S. J. L., Barlassina, C., Bartz, T. M., Beilby, J., Bellis, C., Bergman, R. N., Bergmann, S., Blangero, J., Blüher, M., Boerwinkle, E., Bonnycastle, L. L., Bornstein, S. R., Bruinenberg, M., Campbell, H., Chen, Y. D. I., Chiang, C. W. K., Chines, P. S., Collins, F. S., Cucca, F., Cupples, L. A., D'avila, F., De Geus, E. J. C. N., Dedoussis, G. V., Dimitriou, M., Döring, A., Eriksson, J. G., Farmaki, A. E., Farrall, M., Ferreira, T., Fischer, K., Forouhi, N. G., Friedrich, N., Gjesing, A. P., Glorioso, N., Graff, M., Grallert, H., Grarup, N., Gräßler, J., Grewal, J., Hamsten, A., Harder, M. N., Hartman, C. A., Hassinen, M., Hastie, N., Hattersley, A. T., Havulinna, A. S., Heliövaara, M., Hillege, H., Hofman, A., Holmen, O. L., Homuth, G., Hottenga, J. J., Hui, J., Husemoen, L. L., Hysi, P. G., Isaacs, A., Ittermann, T., Jalilzadeh, S., James, A. L., Jørgensen, T., Jousilahti, P., Jula, A., Marie Justesen, J., Justice, A. E., Kähönen, M., Karaleftheri, M., Tee Khaw, K., Keinanen-Kiukaanniemi, S. M., Kinnunen, L., Knekt, P. B., Koistinen, H. A., Kolcic, I., Kooner, I. K., Koskinen, S., Kovacs, P., Kyriakou, T., Laitinen, T., Langenberg, C., Lewin, A. M., Lichtner, P., Lindgren, C. M., Lindström, J., Linneberg, A., Lorbeer, R., Lorentzon, M., Luben, R., Lyssenko, V., Männistö, S., Manunta, P., Leach, I. M., Mcardle, W. L., Mcknight, B., Mohlke, K. L., Mihailov, E., Milani, L., Mills, R., Montasser, M. E., Morris, A. P., Müller, G., Musk, A. W., Narisu, N., Ong, K. K., Oostra, B. A., Osmond, C., Palotie, A., Pankow, J. S., Paternoster, L., Penninx, B. W., Pichler, I., Pilia, M. G., Polašek, O., Pramstaller, P. P., Raitakari, O. T., Rankinen, T., Rao, D. C., Rayner, N. W., Ribel-Madsen, R., Rice, T. K., Richards, M., Ridker, P. M., Rivadeneira, F., Ryan, K. A., Sanna, S., Sarzynski, M. A., Scholtens, S., Scott, R. A., Sebert, S., Southam, L., Sparsø, T. H., Steinthorsdottir, V., Stirrups, K., Stolk, R. P., Strauch, K., Stringham, H. M., Swertz, M. A., Swift, A. J., Tönjes, A., Tsafantakis, E., Van Der Most, P. J., Van Vliet-Ostaptchouk, J. V., Vandenput, L., Vartiainen, E., Venturini, C., Verweij, N., Viikari, J. S., Vitart, V., Vohl, M. C., Vonk, J. M., Waeber, G., Widén, E., Willemsen, G., Wilsgaard, T., Winkler, T. W., Wright, A. F., Yerges-Armstrong, L. M., Zhao, J. H., Carola Zillikens, M., Boomsma, D. I., Bouchard, C., Chambers, J. C., Chasman, D. I., Cusi, D., Gansevoort, R. T., Gieger, C., Hansen, T., Hicks, A. A., Hu, F., Hveem, K., Jarvelin, M. R., Kajantie, E., Kooner, J. S., Kuh, D., Kuusisto, J., Laakso, M., Lakka, T. A., Lehtimäki, T., Metspalu, A., Njølstad, I., Ohlsson, C., Oldehinkel, A. J., Palmer, L. J., Pedersen, O., Perola, M., Peters, A., Psaty, B. M., Puolijoki, H., Rauramaa, R., Rudan, I., Salomaa, V., Schwarz, P. E. H., Shudiner, A. R., Smit, J. H., Sørensen, T. I. A., Spector, T. D., Stefansson, K., Stumvoll, M., Tremblay, A., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Völker, U., Vollenweider, P., Wareham, N. J., Watkins, H., Wilson, J. F., Zeggini, E., Abecasis, G. R., Boehnke, M., Borecki, I. B., Deloukas, P., van Duijn, C. M., Fox, C., Groop, L. C., Heid, I. M., Hunter, D. J., Kaplan, R. C., McCarthy, M. I., North, K. E., O'connell, J. R., Schlessinger, D., Thorsteinsdottir, U., Strachan, D. P., Frayling, T. M., Hirschhorn, J. N., Müller-Nurasyid, M. & Loos, R. J. F. 23 Nov 2016 In : Nature Communications. 7, 13357

Research output: Contribution to journalArticle

Open Access
loci
Principal Component Analysis
phenotype
Meta-Analysis
Phenotype
3 Citations

Association of Forced Vital Capacity with the Developmental Gene NCOR2

CHARGE consortium & SpiroMeta consortium 2016 In : PLoS One. 11, 2, 17 p., e0147388

Research output: Contribution to journalArticle

Open Access
Developmental Genes
Vital Capacity
Genes
lungs
genes
2 Citations
Cohort Effect
Spirometry
Early Detection of Cancer
Chronic Obstructive Pulmonary Disease
Lung Neoplasms

Genetic Correlation of Lung Function with Anthropometric Measures in the Busselton Health Study

Cadby, G., Melton, P. E., McCarthy, N. S., Hui, J., Beilby, J., Musk, A. . B., James, A. L., Hung, J., Blangero, J. & Moses, E. K. Nov 2016 In : Genetic Epidemiology. 40, 7, p. 625-626 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

5 Citations

Identification of a new locus at 16q12 associated with time to asthma onset

Sarnowski, C. , Sugier, P. E. , Granell, R. , Jarvis, D. , Dizier, M. H. , Ege, M. , Imboden, M. , Laprise, C. , Khusnutdinova, E. K. , Freidin, M. B. , Cookson, W. O. C. , Moffatt, M. , Lathrop, M. , Siroux, V. , Ogorodova, L. M. , Karunas, A. S. , James, A. , Probst-Hensch, N. M. , Von Mutius, E. , Pin, I. & 4 others Kogevinas, M., Henderson, A. J., Demenais, F. & Bouzigon, E. 2016 In : Journal of Allergy and Clinical Immunology. 138, 4, p. 1071-1080

Research output: Contribution to journalArticle

Asthma
Age of Onset
Zona Pellucida
Carrier Proteins
Interleukin-1 Receptors
1 Citations

Identification of STOML2 as a putative novel asthma risk gene associated with IL6R

Revez, J. A., Matheson, M. C., Hui, J., Baltic, S., James, A., Upham, J. W., Dharmage, S., Thompson, P., Martin, N. G., Hopper, J. L. & Ferreira, M. A. R. 14 Jun 2016 In : Allergy: European Journal of Allergy and Clinical Immunology. 71, 7, p. 1020-1030 11 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-6 Receptors
Asthma
Genes
Proteins
Gene Expression
14 Citations

Periostin levels and eosinophilic inflammation in poorly-controlled asthma

Simpson, J. L., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S., James, A., Jenkins, C., Peters, M. J., Jia, G., Holweg, C. T. J. & Gibson, P. G. 30 Apr 2016 In : BMC Pulmonary Medicine. 16, p. 1-7 7 p., 67

Research output: Contribution to journalArticle

Open Access
Sputum
Asthma
Inflammation
Serum
Eosinophils
10 Citations

Reduced antiviral interferon production in poorly controlled asthma is associated with neutrophilic inflammation and high-dose inhaled corticosteroids

Simpson, J. L., Carroll, M., Yang, I. A., Reynolds, P. N., Hodge, S., James, A., Gibson, P. G. & Upham, J. W. Mar 2016 In : Chest. 149, 3, p. 704-713 10 p.

Research output: Contribution to journalArticle

Interferons
Antiviral Agents
Adrenal Cortex Hormones
Asthma
Inflammation
2015
13 Citations

A comprehensive evaluation of a two-channel portable monitor to "rule in" obstructive sleep apnea

Ward, K., Mcardle, N., James, A., Bremner, A., Simpson, L., Cooper, M., Palmer, L. J., Fedson, A. C., Mukherjee, S. A. & Hillman, D. R. 2015 In : Journal of Clincal Sleep Medicine. 11, 4, p. 433-444

Research output: Contribution to journalArticle

Obstructive Sleep Apnea
Polysomnography
Apnea
Equipment and Supplies
Sleep
23 Citations

Anti-inflammatory deficiencies in neutrophilic asthma: Reduced galectin-3 and IL-1RA/IL-1β

Gao, P., Gibson, P. G. E., Baines, K. J., Yang, I., Upham, J. W., Reynolds, P. N., Hodge, S. J., James, A., Jenkins, C. R., Peters, M. J., Zhang, J. & Simpson, J. L. 2015 In : Respiratory Research. 16, 1, p. 1-10

Research output: Contribution to journalArticle

Open Access
Galectin 3
Interleukins
Interleukin-1beta
Anti-Inflammatory Agents
Asthma
24 Citations
Fat Body
Bone Density
Spine
Body Mass Index
Fats
18 Citations

Distribution of airway smooth muscle remodelling in asthma: Relation to airway inflammation

Elliot, J. G., Jones, R. L., Abramson, M. J., Green, F. H., Mauad, T. H., Mckay, K. O., Bai, T. R. & James, A. 2015 In : Respirology. 20, 1, p. 66-72

Research output: Contribution to journalArticle

Open Access
Smooth Muscle
Asthma
Inflammation
Airway Remodeling
Cell Count
880 Citations

Genetic studies of body mass index yield new insights for obesity biology

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Research output: Contribution to journalArticle

Genes
Insulin
Neurology
Lipids
Energy Metabolism
1 Citations
Independent Living
Dihydrotestosterone
Testosterone
Estradiol
Vital Capacity