Research output per year
Research output per year
Personal profile
Biography
Lakshini is a Research Fellow of the Royal Perth Hospital Research Foundation, currently working at the Translation Research Laboratory - Dobney Hypertension Centre, School of Biomedical Sciences, UWA. She graduated with a B.Sc. (Genetics, Biochemistry and Microbiology) from the University of Bangalore in 2006. In 2012, she accepted a research scholar position at the Department of Anatomy and Neurobiology, College of Medicine-University of Tennessee Health Science Centre, Memphis, TN, USA. She completed her PhD in 2018 at the Centre for Diabetes Research, Harry Perkins Institute/UWA.
Lakshini specifically investigates the mechanisms of Sodium Glucose Co-transporter (SGLT) family members in the context of diabetes, with a primary focus on diabetic eye, kidney and heart complications. Additionally, she investigates the role of SGLT family members with a particular focus on the sympathetic nervous system (SNS) in various aspects of hypertension, obesity and metabolic syndrome (MetS), cardiovascular and chronic kidney disease (CVD and CKD).
As an emerging early-career researcher, Lakshini has been successful in attracting competitive grant funding from local and national funding bodies. In addition, her work has been published in reputed journals such as JACC: Basic to Translational Science, Journal of Hypertension, Diabetes Care, iScience, World Journal of Gastroenterology, Investigative Ophthalmology & Visual Science, International Journal of Molecular Sciences, Mediators of Inflammation, The Journal of Obstetrics and Gynaecology Research, Experimental and Molecular Pathology, Neural Regeneration Research, Biomedicines and International Journal of Endocrinology. For her work in the areas of diabetes, diabetic complications and hypertension she has received 15 research prizes and awards. During her research career she has delivered numerous oral presentations at national and international scientific meetings and public forums.
Funding overview
Hypertension Australia
Diabetes Research WA
Raine Medical Research Foundation
Diabetes Australia
Royal Perth Hospital Research Foundation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Establishment and Characterisation of a novel mouse model of Diabetic Retinopathy., The University of Western Australia
Award Date: 21 Dec 2018
B.Sc. (Genetics, Biochemistry and Microbiology), Bangalore University
2003 → 2006
External positions
Demonstrator , Edith Cowan University
2015 → …
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Sympathetic Activation Promotes Sodium Glucose Co-Transporter-1 Protein Expression in Rodent Skeletal Muscle
Matthews, J. R., Herat, L. Y., Schlaich, M. P. & Matthews, V. B., Jul 2024, In: Biomedicines. 12, 7, 14 p., 1456.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Comparing and Contrasting the Effects of the SGLT Inhibitors Canagliflozin and Empagliflozin on the Progression of Retinopathy
Herat, L. Y., Matthews, J. R., Rakoczy, E. P., Schlaich, M. P. & Matthews, V. B., Apr 2023, In: Frontiers in Bioscience - Landmark. 28, 4, 83.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus) -
SGLT1/2 inhibition improves glycemic control and multi-organ protection in type 1 diabetes
Herat, L. Y., Matthews, J. R., Hibbs, M., Rakoczy, E. P., Schlaich, M. P. & Matthews, V. B., 18 Aug 2023, In: Iscience. 26, 8, 107260.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
The Impact of SGLT2 Inhibitors in the Heart and Kidneys Regardless of Diabetes Status
Matthews, J., Herat, L., Schlaich, M. P. & Matthews, V., Sept 2023, In: International Journal of Molecular Sciences. 24, 18, 14243.Research output: Contribution to journal › Review article › peer-review
Open Access10 Citations (Scopus) -
The Sympathetic Nervous System Regulates Sodium Glucose Co-Transporter 1 Expression in the Kidney
Matthews, J., Hibbs, M., Herat, L., Schlaich, M. & Matthews, V., 7 Mar 2023, In: Biomedicines. 11, 3, 12 p., 819.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Web of Science)
Projects
- 6 Finished
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The role of sympathetic activation in sole SGLT-1 inhibitor and dual SGLT-1/2 inhibitor induced cardiorenal protection.
Matthews, V. (Investigator 01), Herat, L. (Investigator 02), Schlaich, M. (Investigator 03) & Matthews, J. (Investigator 04)
Royal Perth Hospital Medical Research Foundation
8/01/24 → 31/12/24
Project: Research
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Dual Inhibition of SGLT1 and 2 with Sotagliflozin– a Novel Approach to Maximize Cardiorenal Protection in Type 1 Diabetes.
Herat, L. (Investigator 01), Matthews, V. (Investigator 02), Schlaich, M. (Investigator 03), Sebastian, O. (Investigator 04), Rakoczy, E. (Investigator 05) & Matthews, J. (Investigator 06)
Diabetes Research Foundation of WA
1/01/23 → 31/07/24
Project: Research
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Mechanisms of SGLT1/2 inhibitor mediated cardiorenal protection
Herat, L. (Investigator 01)
Foundation for High Blood Pressure Research
1/01/23 → 31/12/24
Project: Research
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A novel role for sodium glucose co-transporter 2 in diabetic retinopathy and nephropathy
Herat, L. (Investigator 01)
1/01/20 → 31/12/21
Project: Research
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Determining a novel role for sodium glucose co-transporter 2 in the pathogenesis of diabetic retinopathy.
Herat, L. (Investigator 01), Matthews, V. (Investigator 02), Schlaich, M. (Investigator 03) & Rakoczy, E. (Investigator 04)
Diabetes Research Foundation of WA
1/01/20 → 31/12/20
Project: Research
Prizes
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Early Career Research Rising Stars Award Finalist
Herat, L. (Recipient), 2021
Prize: Other distinction
Activities
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Where Diabetes Meets the Eye: New Glucose-Lowering Drugs and their Benefits in Diabetes
Herat, L. (Speaker)
12 Jul 2023Activity: Service and engagement › Public outreach/ public event
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Sigma Xi (External organisation)
Herat, L. (Member)
Jul 2023 → …Activity: Memberships › Membership of professional association
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Expert Review of Clinical Pharmacology (Journal)
Herat, L. (Reviewer)
2023 → …Activity: Editorial work or peer review of publications › Publication peer review
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Invited reviewer for research grants for ‘Diabetes Research UK'
Herat, L. (Assessor)
2023Activity: Industry and government engagement/consultancy › Grant review responsibilities
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Communications Medicine (Journal)
Herat, L. (Reviewer)
2022 → …Activity: Editorial work or peer review of publications › Publication peer review
Press/Media
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Research shows type 2 diabetes treatment could be used to treat type 1
Herat, L., Matthews, V. & Schlaich, M.
3/08/23
1 item of Media coverage
Press/Media: Press / Media
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‘Wonder drug’ could help with type 1 diabetes.
3/02/23
1 item of Media coverage
Press/Media: Press / Media
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Doctor receives funding to see if drug can help those with diabetes type.
1/12/22
1 item of Media coverage
Press/Media: Press / Media
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‘Faces of Perth's Medical Researchers’ championing medical research at East Metropolitan Heath Services.
15/06/20
1 Media contribution
Press/Media: Press / Media