Research output per year
Research output per year
Equipments Details
Description
The CAMECA NanoSIMS 50 is a new generation ion-microprobe which combines high-lateral and spectral resolution together with high sensitivity.
The coaxial lens design allows the primary beam to be focused to sub-50 nm for Cs+ primary ions and sub-150 nm for O- primary ions. The NanoSIMS 50 uses a rastered ion beam to scan across the sample surface. Secondary ions are sputtered from the sample and extracted to a double-focusing magnetic-sector mass spectrometer. Multiple detectors allow the parallel mapping of up to five ion species, simultaneously.
The high-resolution ion-imaging capability is a powerful and unique feature of the NanoSIMS 50, and is highly suitable for elemental or isotopic mapping at the sub-µm scale. This is a particularly powerful technique for mapping the distribution of isotopic tracers (for example. 15N or 13C in biological experiments). Isotopic ratios can be determined with a precision of one per cent in favourable cases.
The coaxial lens design allows the primary beam to be focused to sub-50 nm for Cs+ primary ions and sub-150 nm for O- primary ions. The NanoSIMS 50 uses a rastered ion beam to scan across the sample surface. Secondary ions are sputtered from the sample and extracted to a double-focusing magnetic-sector mass spectrometer. Multiple detectors allow the parallel mapping of up to five ion species, simultaneously.
The high-resolution ion-imaging capability is a powerful and unique feature of the NanoSIMS 50, and is highly suitable for elemental or isotopic mapping at the sub-µm scale. This is a particularly powerful technique for mapping the distribution of isotopic tracers (for example. 15N or 13C in biological experiments). Isotopic ratios can be determined with a precision of one per cent in favourable cases.
Research technique
- Trace element mapping at sub-µm scale
- Depth profiling
- 3D volumetric imaging
- In situ isotope measurements at µm scale
Fingerprint
Explore the research areas in which this equipment has been used. These labels are generated based on the related outputs. Together they form a unique fingerprint.
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Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA
Ho, D., Kretzmann, J., Norret, M., Toshniwal, P., Veder, J. P., Jiang, H., Guagliardo, P., Munshi, A. M. A., Chawla, R., Evans, C., Clemons, T., Nguyen, M., Kretzmann, A., Blythe, A., Saunders, M., Archer, M., Fitzgerald, M., Keelan, J., Bond, C. S., Kilburn, M., & 3 others, 1 Dec 2018, In: Nature Nanotechnology. 13, 12, p. 1148-1153 6 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Web of Science) -
Engineering monolayer poration for rapid exfoliation of microbial membranes
Pyne, A., Pfeil, M. P., Bennett, I., Ravi, J., Iavicoli, P., Lamarre, B., Roethke, A., Ray, S., Jiang, H., Bella, A., Reisinger, B., Yin, D., Little, B., Muñoz-García, J. C., Cerasoli, E., Judge, P. J., Faruqui, N., Calzolai, L., Henrion, A., Martyna, G. J., & 5 others, 2017, In: Chemical Science. 8, 2, p. 1105-1115 11 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Citations (Scopus) -
High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS
He, C., Hu, X., Jung, R. S., Weston, T. A., Sandoval, N. P., Tontonoz, P., Kilburn, M. R., Fong, L. G., Young, S. G. & Jiang, H., 21 Feb 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 2000-2005 6 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Citations (Scopus)