Supplemental Data: Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton Family Heart Study

Dataset

Description

Supplemental Figure S1 - Correlation between genetic correlations of WHR (y-axis) and BMI (x-axis) for all 596 lipid species. Genetic correlations between lipid species and BMI that are different from zero at a false discovery rate (FDR) of 0.05 are shown with 'B', those between lipid species and WHR that are different from zero at a FDR of 0.05 with 'W', those different from zero at an FDR of 0.05 for both BMI and WHR are shown with 'A', and those genetic correlations not diferent from zero at an FDR of 0.05 for neither BMI and WHR are shown as circles. Abbreviations: WHR: Waist-hip ratio; BMI: body mass index, RhoG: genetic correlation.

Supplemental Figure S2 - Correlations between genetic correlations of WHR (y-axis) and BMI (x-axis) for lipid classes that show opposing direction of effects. Genetic correlations between lipid species and BMI that are different from zero at a false discovery rate (FDR) of 0.05 are shown with 'B', those between lipid species and WHR that are different from zero at a FDR of 0.05 with 'W', those different from zero at an FDR of 0.05 for both BMI and WHR are shown with 'A', and those genetic correlations not diferent from zero at an FDR of 0.05 for neither BMI and WHR are shown as circles. Abbreviations: WHR: Waist-hip ratio; BMI: body mass index, RhoG: genetic correlation; SM: sphingomyelin; PC: phosphatidylcholine; LPC: lysophosphatidycholine; LPC(O): lysoalkylphosphatidylcholine; PE: phosphatidylethanolamine; Cer(d): ceramide.

Supplemental Table S1 - Heritability estimates of 596 lipid species

Supplemental Table S2 - Genetic correlation between lipid classes and cardiovascular disease traits

Supplemental Table S3 - Genetic correlation between lipid species and cardiovascular disease traits
Date made available14 Feb 2020
PublisherAmerican Society for Biochemistry and Molecular Biology

Cite this

Cadby, G. (Creator), Melton, P. (Creator), McCarthy, N. (Creator), Giles, C. (Creator), Mellett, N. A. (Creator), Huynh, K. (Creator), Hung, J. (Creator), Beilby, J. (Creator), Dube, M. (Creator), Watts, G. (Creator), Blangero, J. (Creator), Meikle, P. J. (Creator), Moses, E. (Creator)(14 Feb 2020). Supplemental Data: Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton Family Heart Study. American Society for Biochemistry and Molecular Biology. 10.1194/jlr.RA119000594