Data from: Designer self-assembling hydrogel scaffolds can impact skin cell proliferation and migration

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Description

There is a need to develop economical, efficient and widely available therapeutic approaches to enhance the rate of skin wound healing. The optimal outcome of wound healing is restoration to the pre-wound quality of health. In this study we investigate the cellular response to biological stimuli using functionalized nanofibers from the self-assembling peptide, RADA16. We demonstrate that adding different functional motifs to the RADA16 base peptide can influence the rate of proliferation and migration of keratinocytes and dermal fibroblasts. Relative to unmodified RADA16; the Collagen I motif significantly promotes cell migration, and reduces proliferation.,Keratinocytes on RADA16-Collagen I (1% wt)Live cell tracking migration assay with keratinocytes on RADA16-Collagen I (1% wt).Col1-K.aviFibroblasts on RADA16-Collagen I (1% wt)Live cell tracking migration assay with fibroblasts on RADA16-Collagen I (1% wt).Coll1-F.aviFibroblasts on RADA16-Fibronectin (1% wt)Live cell tracking migration assay with fibroblasts on RADA16-Fibronectin (1% wt).Fibronectin-F.aviKeratinocytes on RADA16-Fibronectin (1% wt)Live cell tracking migration assay with keratinocytes on RADA16-Fibronectin (1% wt).Fibronectin-K.aviFibroblasts on RADA16 (1% wt)Live cell tracking migration assay with fibroblasts on RADA16 (1% wt).rada16-f.aviKeratinocytes on RADA16 (1% wt)Live cell tracking migration assay with keratinocytes on RADA16 (1% wt).rada16-k.avi,
Date made available6 Nov 2015
PublisherDryad Digital Repository

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