Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment: Supplementary material

These files include source data and supplementary tables for the study titled “Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment (MCI)”. The aim of this study was to compare cerebrovascular and systemic vascular function between older adults with and without MCI, and to assess the strength of association between these outcomes. In 41 adults with MCI and 34 adults without MCI (control) we compared middle cerebral artery velocity (MCAv) and cerebrovascular pulsatility index (PI) at rest, cerebrovascular reactivity to CO2 using a breath-hold test, and responsiveness to changes in blood pressure during repeated stand-sit transitions (%∆MCAv/%∆MAP). Systemic vascular function was assessed by flow-mediated dilation (FMD) and aortic stiffness by pulse wave velocity (PWV).




Date collected: October 2016 - October 2018