[Truncated abstract] Melanoma is the most aggressive form of skin cancer and a major public health issue in Western Australia. Melanoma is thought to be the result of complex interactions between genetic, host and environmental factors. Whilst the major host and environmental risk factors have been identified, the genetic determinants and their interactions with environmental factors remain largely undefined. Studies designed to investigate genetic factors in large, representative and population-based samples are required to further elucidate common, low-penetrance melanoma susceptibility genes. Studies at the population-level are also required to investigate potential familial cancer syndromes and predisposition genes for familial cases of melanoma.
Scarring is an issue that affects all melanoma patients, as surgical excision is required by all patients to remove the tumour. There is marked variation in the aesthetic appearance of the resulting scars but limited knowledge regarding the genetic determinants of such non-keloid, surgical scar outcomes. Increased knowledge regarding these factors may help to identify melanoma patients at risk of poor scar outcomes.