Parametric imaging of tissue microstructure using optical coherence tomography: birefringence and elasticity

Research output: ThesisDoctoral Thesis

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[Truncated] Biological tissue has intrinsic optical and mechanical properties that are linked to its structure and function, and are altered by pathologies such as cancer. Techniques for imaging these properties could, thus, aid in the detection, diagnosis, and understanding of disease. Birefringence is one such optical property, arising from structural and molecular anisotropies in tissue and, thus, a measure of the tissue microstructure. Similarly, many pathologies lead to a stiffening or softening of tissues, and, in principle, can be detected from changes in mechanical elasticity. Optical coherence tomography (OCT) is a minimally invasive optical imaging modality, with micrometre-scale resolution and millimetre-scale depth penetration, which can be extended to measure these tissue properties. This research combines three-dimensional OCT imaging with parametric modelling to develop signal processing methods for spatially resolved micro-scale measurements of tissue birefringence and elasticity, an approach referred to as parametric OCT.



Original languageEnglish
QualificationDoctor of Philosophy
StateUnpublished - Apr 2016

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