Environment changes genetic effects on respiratory conditions and allergic phenotypes

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Environment changes genetic effects on respiratory conditions and allergic phenotypes. / Song, Yong; Schwager, Michelle J.; Backer, Vibeke; Guo, Jing; Porsbjerg, Celeste; Khoo, Siew Kim; Laing, Ingrid A.; Moses, Eric K.; LeSouëf, Peter; Zhang, Guicheng.

In: Scientific Reports, Vol. 7, No. 1, 6342, 24.07.2017.

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Harvard

Song, Y, Schwager, MJ, Backer, V, Guo, J, Porsbjerg, C, Khoo, SK, Laing, IA, Moses, EK, LeSouëf, P & Zhang, G 2017, 'Environment changes genetic effects on respiratory conditions and allergic phenotypes' Scientific Reports, vol 7, no. 1, 6342. DOI: 10.1038/s41598-017-06791-y

APA

Song, Y., Schwager, M. J., Backer, V., Guo, J., Porsbjerg, C., Khoo, S. K., ... Zhang, G. (2017). Environment changes genetic effects on respiratory conditions and allergic phenotypes. Scientific Reports, 7(1), [6342]. DOI: 10.1038/s41598-017-06791-y

Vancouver

Song Y, Schwager MJ, Backer V, Guo J, Porsbjerg C, Khoo SK et al. Environment changes genetic effects on respiratory conditions and allergic phenotypes. Scientific Reports. 2017 Jul 24;7(1). 6342. Available from, DOI: 10.1038/s41598-017-06791-y

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Song, Yong; Schwager, Michelle J.; Backer, Vibeke; Guo, Jing; Porsbjerg, Celeste; Khoo, Siew Kim; Laing, Ingrid A.; Moses, Eric K.; LeSouëf, Peter; Zhang, Guicheng / Environment changes genetic effects on respiratory conditions and allergic phenotypes.

In: Scientific Reports, Vol. 7, No. 1, 6342, 24.07.2017.

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@article{323c645f3dc14f59abc079fb6a12744a,
title = "Environment changes genetic effects on respiratory conditions and allergic phenotypes",
abstract = "The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association in a genetically homogeneous, but geographically separated population. We evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R and TNF-α), the lung function and five respiratory/allergic conditions (ever asthma, bronchitis, rhinitis, dermatitis and atopy) in two populations of Inuit residing either in the westernized environment of Denmark or in the rural area of Greenland. Our results showed that lung function was associated with genetic variants in ORMDL3, with polymorphisms having a significant interaction with place of residence. LT-α SNP rs909253 and rs1041981 were significantly associated with bronchitis risk. LT-α SNP rs2844484 was related to dermatitis susceptibility and was significantly influenced by the place of residence. The observed gene-phenotype relationships were exclusively present in one population and absent in the other population. We conclude that the genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment and that environmental factors/lifestyles modify genetic predisposition and change the genetic effects on diseases.",
author = "Yong Song and Schwager, {Michelle J.} and Vibeke Backer and Jing Guo and Celeste Porsbjerg and Khoo, {Siew Kim} and Laing, {Ingrid A.} and Moses, {Eric K.} and Peter LeSouëf and Guicheng Zhang",
year = "2017",
month = "7",
doi = "10.1038/s41598-017-06791-y",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

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TY - JOUR

T1 - Environment changes genetic effects on respiratory conditions and allergic phenotypes

AU - Song,Yong

AU - Schwager,Michelle J.

AU - Backer,Vibeke

AU - Guo,Jing

AU - Porsbjerg,Celeste

AU - Khoo,Siew Kim

AU - Laing,Ingrid A.

AU - Moses,Eric K.

AU - LeSouëf,Peter

AU - Zhang,Guicheng

PY - 2017/7/24

Y1 - 2017/7/24

N2 - The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association in a genetically homogeneous, but geographically separated population. We evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R and TNF-α), the lung function and five respiratory/allergic conditions (ever asthma, bronchitis, rhinitis, dermatitis and atopy) in two populations of Inuit residing either in the westernized environment of Denmark or in the rural area of Greenland. Our results showed that lung function was associated with genetic variants in ORMDL3, with polymorphisms having a significant interaction with place of residence. LT-α SNP rs909253 and rs1041981 were significantly associated with bronchitis risk. LT-α SNP rs2844484 was related to dermatitis susceptibility and was significantly influenced by the place of residence. The observed gene-phenotype relationships were exclusively present in one population and absent in the other population. We conclude that the genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment and that environmental factors/lifestyles modify genetic predisposition and change the genetic effects on diseases.

AB - The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association in a genetically homogeneous, but geographically separated population. We evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R and TNF-α), the lung function and five respiratory/allergic conditions (ever asthma, bronchitis, rhinitis, dermatitis and atopy) in two populations of Inuit residing either in the westernized environment of Denmark or in the rural area of Greenland. Our results showed that lung function was associated with genetic variants in ORMDL3, with polymorphisms having a significant interaction with place of residence. LT-α SNP rs909253 and rs1041981 were significantly associated with bronchitis risk. LT-α SNP rs2844484 was related to dermatitis susceptibility and was significantly influenced by the place of residence. The observed gene-phenotype relationships were exclusively present in one population and absent in the other population. We conclude that the genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment and that environmental factors/lifestyles modify genetic predisposition and change the genetic effects on diseases.

UR - http://www.scopus.com/inward/record.url?scp=85025811969&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-06791-y

DO - 10.1038/s41598-017-06791-y

M3 - Article

VL - 7

JO - Scientific Reports

T2 - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 6342

ER -

ID: 18505350