Elucidating the role of sorting nexins in skeletal homeostasis

Research output: ResearchDoctoral Thesis

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The growth and repair of the skeleton are tightly regulated processes that depend on the ability of cells to respond to local and systemic stimuli through surface receptors. The parathyroid hormone receptor type 1 (PTHR) is a class B G protein-coupled
receptor critical for bone growth, remodelling and mineral ion metabolism. In response to stimulation, PTHR elicits signalling
at the cell surface and from within the endosome following receptor internalisation. Sorting Nexin 27 (SNX.27, the only postsynaptic-95, Dlg-1, Z0-1 (PDZ) domain-containing protein of its family) together with retromer, are required for the endosome-to-PM retrieval and therefore, signal termination of PTHR.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
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Thesis sponsors
  • Australian Government Research Training Program
Award date24 Jan 2018
DOIs
StateUnpublished - 2018


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