Early life egg allergen exposure in the primary prevention of egg allergy

Research output: ResearchDoctoral Thesis

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  • THESIS - DOCTOR OF PHILOSOPHY - METCALFE Jessica Rene - 2017

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Abstract

Background: Food allergy now affects 1 in 10 Australian infants, highhghting the need for effective prevention strategies.
Methods: I investigated the effect of egg exposure on infant egg-specific immune responses, both with solid foods Introduction and through breast milk.
Results: Prior to the introduction of solid foods, infants had elevated Th2 cytokine responses to egg that predicted the development of egg allergy. Maternal egg ingestion during in the first 6 weeks of breastfeeding were also shown to beneficially effect egg-specific immune responses in infants.
Conclusions: These findings highlight an important period of egg specific immune development prior to solid food Introduction.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Award date30 Mar 2017
StateUnpublished - 2017


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