Comparative phylogenomics and antimicrobial resistance in livestock-associated lineages of Clostridium difficile

Research output: ThesisDoctoral Thesis



  • THESIS - DOCTOR OF PHILOSOPHY - KNIGHT Daniel Raymond - 2018

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Research units


Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen of international One Health importance. This thesis provides novel insights into the genetic diversity, evolutionary history, and zoonotic potential of C. difficile isolated from livestock and humans in Australia. Critically, this work has shown that livestock in Australia are reservoirs for clinically important, multi-drug resistant strains of C. difficile with a clear potential for interspecies transmission between animals and humans, findings which challenge the long-held misconception that C. difficile infection (CDI) is primarily a healthcare-associated infection.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Thesis sponsors
  • Australian Government Research Training Program
Award date28 Feb 2018
StateUnpublished - 2018

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