Researcher Profile

Emeritus Professor Miranda Grounds

Miranda Grounds
Miranda Grounds

Phone: +61 8 6488 3486

Research Expertise:
  • Muscular dystrophy
  • Factors affecting necrosis and repair of skeletal muscle
  • Cell and gene therapy for muscle diseases
  • Muscle wasting due to ageing, disease, cachexia or disuse
  • Muscle hypertrophy
  • Myoblasts and stem cells
  • Anti-cytokine therapies
  • Cell and molecular biology
  • Developmental biology
  • Extracellular matrix
  • Growth factors
  • Inflammation
  • Oxidative stress
  • Dysferlinopathies


BSc W.Aust., PhD Lond.

Current Projects

Jain Foundation: Monitoring & Reducing Oxidative Stress Associated with Dystropathology in Dysferlin Deficient Mice. Funds Approved $57,752.82

Medical Health and Research Infrastructure Fund Round 14 (2010). Funds Approved $35,149.00

NHMRC 2009-2011: Role of IGF-1 in skeletal muscle hypertrophy and atrophy. Funds Approved $379,500.00

Previous Positions

1994-1998 Senior Research Fellow (NHMRC), UWA.
1980-1994 Senior Research Officer (NHMRC), UWA.
1978-1980 Research Officer, UWA.
1975-1978 Research Biochemist, Charing Cross Hospital, London.
1972-1974 Research Assistant, UWA.

New and Noteworthy

The research over 30 years has provided many pioneering studies in the general area of regeneration of adult skeletal muscle and therapies for muscular dystrophy. Some ‘firsts’ include the first bone- marrow reconstitution study to test for circulating myogenic stem cells (1983[28 citations]) about 15 years before this topic became fashionable, with a sustained current interest in myogenic stem cells: many researchers now generally agree with the conclusions of this early paper. Use of in vivo autoradiography tested and caused the demise of the tissue culture quantal mitosis theory (1987[43]) and documented kinetics of myoblast proliferation during myogenesis in damaged adult muscle in vivo (1985-1992 e.g 1987[96]). Demonstration by electron microscopy of new plasmalemma formation after damage and myogenic fusion in vivo (1990[45] & [36]). Identification of muscle precursor cells in vivo by use of MyoD1 and myogenin probes (1992[177]). Many studies of the role of inflammation in regeneration (e.g 1993[142]). Development of the mouse Y-chromosome probe as a new marker to visualise and quantitate transplanted male mouse cells (1991-) and describe massive rapid loss of cultured donor myoblasts in vivo (1996[110]) as well as quantification of such cell death – then widely used as a cell marker internationally. First report that blockade of TNF reduces the severity of muscular dystrophy (2004[72]). Many studies of transgenic over-expression of IGF-1 in muscles that challenge established views (2004[41] and 2005[52]). Many reviews have received high citations e.g on regeneration (1991[234 & 1999[77]), muscular dystrophy (2008[26]), myogenic stem cells (2002[107]) and ageing (1998[108] & 2002[66]). Activities in all of these areas (and more) continue unabated as outlined for publications in the last 5 years.


Committees and Conference organisation.
MG has been extensively involved in organisation of about 20 Conferences. Two major initiatives that have resulted in ongoing conferences were:
Initiating (and joint Convenor with George Yeoh) of the Combined Biological Sciences conference in 1990. This is now a major annual meeting in Perth.
Member of international Steering committee for a new meeting on “Satellite cells, regeneration and skeletal muscle diseases” 1998, in Boston. Now a regular event.
Some recent Conference and Symposia organisation is indicated below.
2000 Organiser for major TERC meeting "Frontiers in Tissue Engineering: West Australian Symposium", University of Western Australia, October, 2000.
2001 Organiser “The Cottesloe Beach Muscle Symposium”, Perth, Sept 2001.
2002 Organiser for TERC “Stem cell and Tissue Engineering Symposium”, Perth, November 2002.
2002-2007 Organiser for series of “Molecular Mechanisms of Development” Conferences, Perth. 2004 Organising Committee: Matrix Biology Society of Australia & New Zealand meeting, Rottnest, WA, Sept 2004.
2003-2004 Co-Chair of programme committee for COMBIO 2004, Perth, September 2004.
2005- Organising Committee: Austr. Neuroscience Soc. Conference, Perth, Feb 2005.
2006 Organising Committee: Focus on Microscopy, Perth, April 2006.

Membership of Societies

Australian and New Zealand Society for Cell & Developmental Biology (ANZSCDBI). President of ANZSCDB from 1996-1998; Australian Society for Medical Research (ASMR); Australian Society for Biochemistry & Molecular Biology (ASBMB); Matrix Biology; World Muscle Society; Tissue Engineering Society International.
Membership of Boards: serves on 3 journal Editorial Boards; J Meat & Livestock (Australia) Scientific Advisory Board (2002-2009) plus Sheep Functional Genomics Program Consultative Committee (2003-2009); Bioheart (USA Company) Scientific Advisory Board (2003-); Norwegian Parent Project Advisory Committee (2006-); International Society of Differentiation Board Member (2006- )

Funding Received

Medical Health and Research Infrastructure Fund.
The International Parent Project.
Association Francaise contre les Myopathies.
Muscular Dystrophy Association of America 2000.
Heart Foundation, Australia.
Meat & Livestock, Australia.
National Health and Medical Research Council of Australia.
The Arnold Yeldham and Mary Raine Medical Research Foundation,UWA.
Medical Research Council of W.A.
Jain Foundation

Roles, responsibilities and expertise

Prof Miranda Grounds (MG) with a BSc(Hons) from the University of Western Australia (UWA) and PhD from the University of London (1978), obtained her first NH&MRC grant in 1980 and in 1994 became an NH&MRC Senior Research Fellow and Professor in the School of Anatomy and Human Biology, UWA. For over 30 years, the research of MG has focussed on factors controlling damage and repair of skeletal muscle and on potential treatments for muscle diseases, with a strong focus on in vivo studies and tissue analyses. Some ‘firsts’ include the first bone- marrow reconstitution study to test for circulating myogenic stem cells (1983), use of autoradiography to test and challenge the tissue culture quantal mitosis theory in vivo (1987) and document kinetics of myogenesis in damaged adult muscle in vivo (1985-1992), development of the Y-chromosome probe to visualise and quantitate male mouse cells (1991-) and describe massive rapid loss of cultured donor myoblasts in vivo (1996). MG has over 150 publications, 20 since 2008, with strong citations: H-Factor = 37 (March 2011, Citation sum is 3995 and Av./item is 25.05). The research covers diverse areas including; Muscle regeneration, Stem cells; Myoblast Transfer Therapy and other therapies for Muscular Dystrophies; Muscle hypertrophy and atrophy; plus Ageing (6 related papers and reviews since 1998). Recent research has focussed on factors controlling the maintenance of muscle mass and function into old age.
Since 2000, MG has supervised 16 PhD students (9 are current) and over 20 Honours students (12 with 1st class). MG has organised numerous conferences, is a reviewer for many international funding agencies and journals, and serves on Editorial and various other Boards and committees including: Board of the International Society of Differentiation since 2006 and, since 2010, Member of the Fundamental Myology commission of the Association contre les Myopathies (AFM) Scientific Council, plus Member of the TREAT-NMD Advisory Committee for Therapeutics (TACT) (these involve fully paid trips each year). In 2005 MG received an Excellence in Postgraduate Supervision Award, UWA and was the recipient of the Barry Preston Award from the Matrix Biology Society of Australia and New Zealand; in 2012, MG will present the prestigious Mauro lecture at the 2012 international Satellite Cell meeting (the first female to receive this honour).
These research achievements are widely recognized internationally as evidenced by invited reviews/Chapters and also overseas grants, and MG has obtained about $10.5 million in funding. International recognition is also demonstrated by many invitations for MG to speak at national/international conferences/workshops (>100 since 1980),with 12 fully paid international invitations since 2010. Some recent relevant invitations are: 2005 ●FASEB Skeletal muscle satellite and stem cells. USA; ●Translational Medicine for skeletal muscle biology, Sweden; ●Novartis Muscle Workshop, Switzerland. 2007 ●Workshop (NIH): Pre-clinical testing for Duchenne dystrophy, USA. ●Keynote: Medical Sciences Congress, New Zealand, ●Stem Cell Therapy for Skeletal Muscle Myopathies, France. ●Plenary: 4th Cachexia Conference, Florida, USA 2008 ●Bispebjerg Symposium on Sports Medicine, Denmark 2009 ●Workshop: Programs specifying muscle identity, with a possible link to disease, France ●Workshop: Current bottlenecks in translational medicine in inherited neuromuscular diseases (Treat-NMD/NIH), Belgium. 2010 ●Gage Conference on Muscle, Canberra, Australia ●Muscle Satellite Symposium, Queenstown Molecular Biology, New Zealand. ●Jain Foundation, Seattle, USA. ●16th Intl Soc. Differentiation, Japan. 2011 ● Myology 2011 (AFM), Lille, France, ●Gordon Conference, New Horizons for Myogenesis, Therapies for Aging and Dystrophy, USA. (plus invited talk at EU MyoAGE meeting, Finland) 2012 ●MG will present the 7th Mauro lecture at the 2012 Satellite Cell meeting, Italy.


For over 30 years, the research of M Grounds has focussed on factors controlling the repair of damaged skeletal muscle and on potential treatments for muscle diseases such as Duchenne’s muscular dystrophy and muscle wasting, with a focus on in vivo studies and tissue analyses. Her research has pioneered many studies into factors controlling skeletal muscle regeneration with a particular emphasis on myogenesis in post-natal skeletal muscle in vivo, and an ongoing interest in the role of the extracellular matrix. Research on cell therapies developed the Y-chromosome probe for tracking male nuclei and identified the massive and rapid death of injected donor cells in Myoblast Transfer Therapy. Other projects investigate stem cell therapies (MG published the first bone-marrow reconstitution experiments to look for bone-marrow derived muscle stem cells in 1983) and Tissue Engineering for skeletal and cardiac muscle. Current research includes the in vivo role of IGF-1 isoforms, a focus on inflammation and anti-cytokine therapies, metabolism, and oxidative stress, all with applications to skeletal muscle wasting with ageing, muscular dystrophy and especially age-related loss of muscle mass and function (Sarcopenia).

ID: 15584

Most frequent journals
  • Experimental Cell Research

    ISSNs: 0014-4827, 1090-2422

    Academic Press

    Scopus rating (2016): CiteScore 3.44 SJR 1.676 SNIP 0.899

    Journal: ERA2018


    ISSNs: 0960-8966, 1873-2364


    Scopus rating (2016): CiteScore 2.36 SJR 1.299 SNIP 1.027

    Journal: ERA2018

  • International Journal of Biochemistry and Cell Biology

    ISSNs: 1357-2725, 1878-5875


    Scopus rating (2016): CiteScore 3.81 SJR 1.782 SNIP 1.058

    Journal: ERA2018

  • Cell Transplantation

    ISSNs: 0963-6897, 1555-3892

    SAGE Publications Ltd

    Scopus rating (2016): CiteScore 2.97 SJR 1.015 SNIP 0.865

    Indexed in DOAJ

    Journal: ERA2018

  • Cell and Tissue Research

    ISSNs: 0302-766X, 1432-0878

    Springer-Verlag London Ltd.

    Scopus rating (2016): CiteScore 2.82 SJR 1.29 SNIP 0.888

    Journal: ERA2018

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